Latest research: Spermidine supplementation can improve the fertility of mice or help extend reproductive life drug research and development

BEIJING, Oct. 17 (Reporter Sun Zifa) Springer Nature's professional academic journal Nature Aging recently published a research paper by the Chinese scientific research team, pointing out that supplementation of spermidine, a polyamine metabolite, can improve the oocyte quality and fertility of elderly female mice. This research result may promote therapeutic research on reproductive life, To provide drug research and development strategies for prolonging female reproductive life.

In this paper, recent research has explored drug strategies to improve age-related ovarian dysfunction and fertility impairment, hoping to improve overall health and reduce age-related infertility. Spermidine is a naturally occurring polyamine that can extend the life span of many organisms. Previous studies have found that spermidine may be beneficial to the physiological function of ovary and uterus, but the effect of spermidine on the reproductive system of elderly female mice has not been studied in detail.

In this study, Xiong Bo, the corresponding author of the paper and professor of Nanjing Agricultural University, and his colleagues observed that the level of spermidine in the ovaries of elderly mice was lower than that of young mice. This decline was accompanied by the decline of oocyte quality and other signs of ovarian aging. They have proved that spermidine supplementation can improve the spermidine level in the ovaries of elderly mice, promote follicular development and oocyte maturation, and also improve in vitro fertilization ability and blastocyst formation.

The authors believe that the effect of spermidine on the recovery of old mouse oocytes is at least partly mediated by the elimination of damaged mitochondria and the enhancement of mitochondrial function. In addition, they repeated the above results in pig oocytes under oxidative stress - oxidative stress is a major feature of aging.

The "News and Views" article of peer experts published by Nature Aging at the same time said that this research result provides another drug strategy for extending female reproductive life, but further research is still needed to determine the safety and effectiveness of this strategy for human transformation. (End)

key word: Spermidine Aged mice Polyamine oocyte Natural aging