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研究发表/论文

本公司在各个领域与大学、公共机构、企业一起积极推进共同研究,并在论文等中发表了成果。关于近年来的发表,我来介绍其中的一部分。

基因工程相关/其他

  • All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity
    T.Morita, K.Miyakawa, S.S.Jeremiah, Y.Yamaoka, M.Sada, T.Kuniyoshi, J.Yang, H.Kimura, A.Ryo
    Viruses, 13(8), 1669(2021).
  • 对新型日冕病毒的抑制剂筛选法的开发及其应用
    森田武志、宫川敬、山冈悠太郎、国吉智子、梁明秀
    FRAGRANCE JOURNAL, 6, 32-38(2021).
  • Rapid detection of neutralizing antibodies to SARS-CoV-2 variants in post-vaccination sera
    K.Miyakawa, J.S.Stanleyraj, H.Kato, Y.Yamaoka, H.Go, S.Yajima, T.Shimada, T.Mihara, A.Goto, T.Yamanaka, A.Ryo
    Journal of Molecular Cell Biology, mjab050(2021).
  • 新型日冕病毒感染症的病态和免疫
    久保创介、山冈悠太郎、宫川敬、梁明秀
    传染病和预防卫生,  5(1),  10-17(2021).
  • Combining IL-6 and SARS-CoV-2 RNAaemiabased risk stratification for fatal outcomes of COVID-19
    R.Saji, M.Nishii, K.Sakai, K.Miyakawa, Y.Yamaoka, T.Ban, T.Abe, Y.Ohyama, K.Nakajima, T.Hiromi, R.Matsumura, N.Suzuki, H.Taniguchi, T.Otsuka, Y.Oi, F.Ogawa, M.Uchiyama, K.Takahashi, M.Iwashita, Y.Kimura, S.Fujii, R.Furuya, T.Tamura, A.Ryo, I.Takeuchi
    PLoSONE 16(8): e0256022(2021).
  • Evaluation of a combination protocol of CT-first triage and active telemedicine methods by a selected team tackling COVID-19: An experimental research study
    S.Miyake, T.Higurashi, H.Katoa, Y.Yamaoka, T.Kessoku, S.Kato, F.Ogawa, Y.Oia, A.Nakajima, T.Yamamoto, I.Takeuchi, A.Ryoe, S.Maeda
    Journal of Infection and Public Health, 14(9), 1212–1217(2021).
  • Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests
    Y.Yamaoka, K.Miyakawa, S.S.Jeremiah, R.Funabashi, K.Okudela, S.Kikuchi, J.Katada, A.Wada, T.Takei, M.Nishi, K.Shimizu, H.Ozawa, S.Usuku, C.Kawakami, N.Tanaka, T.Morita, H.Hayashi, H.Mitsui, K.Suzuki, D.Aizawa, Y.Yoshimura, T.Miyazaki, E.Yamazaki, T.Suzuki, H.Kimura, H.Shimizu, N.Okabe, H.Hasegawa, A. Ryo
    Cell Reports Medicine(2021).  doi: 10.1016/j.xcrm.2021.100311
  • Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 Survivors
    A.Goto, H.Go, K.Miyakawa, Y.Yamaoka, N.Ohtake, S.Kubo, S.S.Jeremiah, T.Mihara, K.Senuki, T.Miyazaki, S.Ikeda, T.Ogura, H.Kato, I.Matsuba, N.Sanno, M.Miyakawa, H.Ozaki, M.Kikuoka, Y.Ohashi, A.Ryo, T.Yamanaka
    frontiers in Microbiology(2021). doi: 10.3389/fmicb.2021.661187
  • Severe acute respiratory syndrome coronavirus 2 prevalence in saliva and gastric and intestinal fluid in patients undergoing gastrointestinal endoscopy in coronavirus disease 2019 endemic areas: Prospective cross-sectional study in Japan
    S.Miyake, K.Ashikari, S.Kato, T.Takatsu, H.Kuwashima, H.Kaneko, K.Nagai, I.Watari, T.Sato, Y.Yamaoka, T.Yamamoto, A.Ryo, S.Maeda, A.Nakajima, T.Higurashi
    Digestive Endoscopy(2021), doi: 10.1111/den.13945
  • Development of Monoclonal Antibodies and Antigen-Capture ELISA for Human Parechovirus Type 3
    K.Goto, Y.Yamaoka, H.Khatun, K.Miyakawa, M.Nishi, N.Nagata, T.Yanaoka, H.Kimura, A.Ryo
    Microorganisms, 8, 1437(2020).
  • Rapid multiplex microfiber-based immunoassay for anti-MERS-CoV antibody detection
    C.F.O.Hoy, K.Kushiro, Y.Yamaoka, A.Ryo, M.Takai
    Sensing and Bio-Sensing Research, 26, Article 100304(2019).
  • Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa associated polyomavirus
    H.Khatun, Y.Yamaoka, Y.Matsushima, S.Matsunaga, H.Kimura, J.Ho, M.Shuda, A.Ryo
    Microbiology and Immunology, 62(12),763-773(2018).
  • Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide
    K. Miyakawa, S. Matsunaga, Y. Yamaoka, M. Dairaku, K. Fukano, H. Kimura, T. Chimuro, H. Nishitsuji, K. Watashi, K. Shimotohno, T. Wakita, A. Ryo
    Oncotarget, 9(34), 23681-23694 (2018).
  • Development of a bench-top extracleanroom for DNA amplification
    H. Takahashi, T. Satoh, H. Kanahara, Y. Kubota, T. Hirose, H. Yamazaki, K. Yamamoto, Y. Okamura, T. Suzuki, T. Kobori
    BioTechnique, 61(1), 42-46 (2016).
  • Discrimination of rat Brunner's gland carbohydrate antigens by site-specific monoclonal antibodies
    T. Chimuro, H. Kuroyama, Y. Goso, K. Ishihara, M. Kurihara
    Carbohydrate Research, 432, 76-82 (2016).
  • Development of Monoclonal Antibody and Diagnostic Test for Middle East Respiratory Syndrome Coronavirus Using Cell-Free Synthesized Nucleocapsid Antigen
    Y. Yamaoka, S. Matsuyama, S. Fukushi, S. Matsunaga, Y. Matsushima, H. Kuroyama, H. Kimura, M. Takeda, T. Chimuro, A. Ryo
    Frontiers in Microbiology, 7, 509 (2016).
  • 微生物1细胞ー解析向全基因组放大法改良
    高桥宏和、山嵜裕之、小堀俊郎
    生物科学和工业,72(6),492-493(2014)。
  • Preparation of Phi29 DNA Polymerase Free of Amplifiable DNA Using Ethidium Monoazide, an Ultraviolet-Free Light-Emitting Diode Lamp and Trehalose
    H. Takahashi, H. Yamazaki, S. Akanuma, H. Kanahara, T. Saito, T. Chimuro, T. Kobayashi, T. Ohtani, K. Yamamoto, S. Sugiyama, T. Kobori
    PLOS ONE, 9(2), e82624/1-e82624/9 (2014).

细胞培养相关

  • A live imaging-friendly slice culture method using collagen membranes
    A.Ogaki, T.Araki, M.Ishikawa, Y.Ikegaya, R.Koyama
    Neuropsychopharmacology Reports, 40, 307–313(2020).
  • Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing
    H.Kojima, H.Yamaguchi, T.Sozu, N.Kleinstreuer, L.Chae-Hyung, W.Chen, M.Watanabe, T.Fukuda, K.Yamashita, T.Takezawa
    Alternatives to Laboratory Animals, 47(3-4),140-157(2019).
  • Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
    S.Nakai, I.Shibata, T.Shitamichi, H.Yamaguchi, N.Takagi, T.Inoue, T.Nakagawa, J.Kiyokawa, S.Wakabayashi, T.Miyoshi, E.Higashi, S.Ishida, N.Shiraki, S.Kume
    Biology Open , 8, bio042192(2019).
  • Fabrication of a corneal model composed of corneal epithelial and endothelial cells via a collagen vitrigel membrane functioned as an acellular stroma and its application to the corneal permeability test of chemicals
    H. Yamaguchi, T. Takezawa
    Drug Metabolism and Disposition, 46(11), 1684-1691(2018).
  • 动物实验替代法中皮肤评价模型的制作和评价
    采用骨胶原Bitori凝胶膜Chamber的眼睛刺激性试验方法

    竹泽俊明、山口宏之
    皮肤的安全性和有用性评价法,株式会社技术信息协会,2018,pp.77-77。
  • Predictive performance of the Vitrigel-eye irritancy test method using 118 chemicals
    H. Yamaguchi, H. Kojima, T. Takezawa
    Journal of Applied Toxicology, 36(8), 1025-1037 (2016).
  • Fluid dwell impact induces peritoneal fibrosis in the peritoneal cavity reconstructed in vitro
    Aoki, M. Noguchi, T. Takezawa, S. Ikeda, K. Uchihashi, H. Kuroyama, T.Cimuro, S. Toda
    Journal of Artificial Organs, 19(1), 87-96 (2016).
  • 适合三次元培养的新细胞培养用器材®
    高木信幸
    清洁技术,2014(3),71-74(2014)。

诊断试剂相关

  • Development of highly sensitive and rapid antigen detection assay for diagnosis of COVID-19 utilizing optical waveguide immunosensor
    R.Funabashi, K.Miyakawa, Y.Yamaoka, S.Yoshimura, S.Yamane, J.S.Stanleyraj, K.Shimizu, H.Ozawa, C.Kawakami, S.Usuku, N.Tanaka, E.Yamazaki, H.Kimura, H.Hasegawa, A.Ryo
    Journal of Molecular Cell Biology ,mjab037(2021).
  • 新型冠状病毒的抗原・抗体检查法
    山冈悠太朗、梁明秀
    神奈川县公共卫生学会杂志第66号(2021)。
  • 新型日冕病毒感染症的检查诊断法
    山冈悠太朗、梁明秀
    感染控制和预防卫生,4(1),9-15(2020)。
  • 尿中儿科尔胺类及其代谢物中酸性蓄尿用添加剂“酸性百合较大·T”的适用评价
    中浦秀章、加藤雅子、粗恭子、高笠信之
    THE CHEMICAL TIMES, 231, 13-17 (2014).

微生物检查相关

电泳相关/其他

  • 蛋白质检测用荧光分子探针的创建和向高通量检测方法的展开
    铃木祥夫、高木信幸
    生物物理化学。

有机合成、催化相关

  • Double-Helix Supramolecular Nanofibers Assembled from Negatively Curved Nanographenes
    K.Kato, K.Takaba, S.M-Yonekura, N.Mitoma, Y.Nakanishi, T.Nishihara, T.Hatakeyama, T.Kawada, Y.Hijikata, J.Pirillo, L.T. Scott, K.Yonekura, Y.Segawa, K.Itami
    Journal of The American Chemical Society, doi;10.1021/jacs.1c00863
  • Reductive Amination of Ketonic Compounds Catalyzed by Cp*Ir(III) Complexes Bearing a Picolinamidato Ligand
    K.Tanaka, T.Miki, K.Murata, A.Yamaguchi, Y.Kayaki, S.Kuwata, T.Ikariya, M.Watanabe
    The Journal of Organic Chemistry, 84, 10962-10977(2019).
  • Asymmetric Hydrogenation of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos/PICA Derivative–Ruthenium(II) Complexes
    N.Utsumi, N.Arai, K.Kawaguchi, T.Katayama, T.Yasuda, K.Murata, T.Ohkuma
    ChemCatChem, 10(18), 3955-3959, 2018.
  • Computationally-Led Ligand Modification using Interplay between Theory and Experiments: Highly Active Chiral Rhodium Catalyst Controlled by Electronic Effects and CH-π Interactions
    T. Korenaga, R. Sasaki, T. Takemoto, T. Yasuda, M. Watanabe
    Advanced Synthesis & Catalysis, 360, 322-333,(2018).
  • Palladium-Catalyzed Decarbonylative Cross-Coupling of Azinecarboxylates with Arylboronic Acids
    K. Muto, T. Hatakeyama, K. Itami, J. Yamaguchi
    Organic Letters, 18(19), 5106-5109 (2016).
  • C-H arylation and alkenylation of imidazoles by nickel catalysis : solvent-accelerated imidazole C-H activation
    K. Muto, T. Hatakeyama, J. Yamaguchi, K. Itami
    Chemical Science, 6, 6792-6798 (2015).
  • Hydrogenation of nitroarenes with palladium nanoparticles stabilized by alkyne derivatives in homogeneous phase
    N. Arai, N. Onodera, A. Dekita, J. Hori, T. Ohkuma
    Tetrahedron Letters, 56(25), 3913-3915 (2015).

有机材料相关

  • 离子性高分子凝胶化剂的开发
    高崎干大
    月间精细化学,45(10),47-55(2016)。
  • Novel Hole-Transporting Materials with High Triplet Energy for Highly Efficient and Stable Organic Light-Emitting Diodes
    H. Fukagawa, T. Shimizu, H. Kawano, S. Yui, T. Shinnnai, A. Iwai, K. Tsuchiya, T. Yamamoto
    The Jounal of Physical Chemistry C, 120(33), 18748-18755 (2016).

电子工业药品相关

无机材料相关

  • 将用聚乙烯醇制造的苯基氰化铜用于Cs吸附材料的离子层析成像,137Cs浓缩飞灰的去除
    市川恒树、山田一夫、岩井良太、金泽幸广
    环境放射能除染学会志,8(2),55-66(2020)。
  • Analysis of Cs-adsorption behavior using a column filled with microcapsule beads of potassium copper hexacyanoferrate
    G. Kido, M. Takasaki, K. Minami, H. Tanaka, H. Ogawa, T. Kawamoto, K. Yoshino
    Journal of nuclear science and technology, 54(11), 1157-1162 (2017).
  • Decomposition of Iron Hexacyabnoferrate Microcapsule Beads Using Superheated Steam
    K. M. Lee, M. Asai, T. Uchida, T. Kawamoto, K. Minami, A. Takahashi, D. Parajuli, G. Kido, M. Takasaki, K. Yoshino, H. Tanaka
    Chemistry Letters, 45(6), 670-672 (2016).
  • Improved adsorption properties of granulated copper hexacyanoferrate with multi-scale porous networks
    K. M. Lee, T. Kawamoto, K. Minami, A. Takahashi, D. Parajuli, G. Kido, K. Yoshino, H. Tanaka
    RSC Advances, 6, 16234-16238 (2016).
  • Comparative study of the factors associated with the application of metal hexacyanoferrates for environmental Cs decontamination
    D. Parajuli, A. Takahashi, H. Noguchi, A. Kitajima, H. Tanaka, M. Takasaki, K. Yoshino, T. Kawamoto
    Chemical Engineering Journal, 283, 1322-1328 (2016).
  • Prussian blue (PB) granules for cesium (Cs) removal from drinking water
    G. Ru. Chen, Y. R. Chang, X. Liu, T. Kawamoto, H. Tanaka, A. Kitajima, D. Parajuli, M. Takasaki, K. Yoshino, M. L. Chen, Y. K. Lo, Z. Lei, D. J. Lee
    Separation and Purification Technology, 143, 146-151 (2015).