研究发表/论文
本公司在各个领域与大学、公共机关、企业一起积极推进共同研究,并在论文等中发表了其成果。关于近年来的发表,我来介绍一下其中的一部分。
基因工程相关/其他
- Development of a contacting transwell co-culture system for thein vitropropagation of primary central nervous system lymphoma
M.Nishi, K.Tateishi, J.S.Sundararaj, Y.Ino, Y.Nakai, Y.Hatayama, Y.Yamaoka, Y.Mihana, K.Miyakawa, H.Kimura, Y.Kimura, T.Yamamoto, A.Ryo
Frontiers in Cell and Developmental Biology, doi: 10.3389/fcell.2023.1275519
- Generation and Utilization of a Monoclonal Antibody against Hepatitis B Virus Core Protein for a Comprehensive Interactome Analysis
Y.Nakai, K.Miyakawa, Y.Yamaoka, Y. Hatayama, M.Nishi, H.Suzuki, H.Kimura, H.Takahashi, Y.Kimura, A.Ryo
Microorganisms, 10, 2381(2022).
- Development of a Monoclonal Antibody Targeting HTLV-1 Envelope gp46 Glycoprotein and Its Application to Near-Infrared Photoimmuno-Antimicrobial Strategy
Y. Hatayama, Y.Yamaoka, T.Morita, S.S.Jeremiah, K.Miyakawa, M.Nishi, Y.Kimura, M.Mitsunaga, T.Iwase, H.Kimura, N.Yamamoto, A.Takaori-Kondo, H.Hasegawa, A.Ryo
Viruses, 14, 2153 (2022).
- Development of Parallel Reaction Monitoring Mass Spectrometry Assay for the Detection of Human Norovirus Major Capsid Protein
Y.Kimura, J.Shin, Y.Nakai, M.Takahashi, Y.Ino, T.Akiyama, K.Goto, N.Nagata, Y.Yamaoka, K.Miyakawa, H.Kimura, A.Ryo
Viruses, 14(7), 1416(2022).
- Characterization and Utilization of Disulfide-Bonded SARS-CoV-2 Receptor Binding Domain of Spike Protein Synthesized by Wheat Germ Cell-Free Production System
Y.Yamaoka, S.S.Jeremiah, R.Funabashi, K.Miyakawa, T.Morita, Y.Mihana, H.Kato, A.Ryo
Viruses, 14(7), 1461(2022).
- Vaccine-induced humoral response against SARS-CoV-2 dramatically declined but cellular immunity possibly remained at 6 months post BNT162b2 vaccination
H.Kato, K.Miyakawa, N.Ohtake, Y.Yamaoka, S.Yajima, E.Yamazaki, T.Shimada, A.Goto, H.Nakajima, A.Ryo
Vaccine, 40, 2652–2655(2022).
- Molecular and Epidemiological Characterization of Emerging Immune-Escape Variants of SARS-CoV-2
K.Miyakawa, S.S.Jeremiah, Y.Yamaoka, T.Koyama, R.Tokumasu, M.Kudo, H.Kato, A.Ryo
frontiers in Medicine, 10(2022).
- 针对新型冠状病毒感染症的抗原检查法
山冈悠太郎、宫川敬、森田武志、梁明秀
感染控制和预防卫生,5(2),8-14(2021)。
- Antibody titers against the Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2 induced by BNT162b2 vaccination measured using automated chemiluminescent enzyme immunoassay
H.Kato, K.Miyakawa, N.Ohtake, H.Go, Y.Yamaoka, S.Yajima, T.Shimada, A.Goto, H.Nakajima, A.Ryo
Journal of Infection and Chemotherapy, 28, 273–278(2022).
- Phosphopeptide enrichment using Phos-tag technology reveals functional phosphorylation of the nucleocapsid protein of SARS-CoV-2
Y.Ino, M.Nishi, Y.Yamaoka, K.Miyakawa, S.S.Jeremiah, M.Osada, Y.Kimura, A.Ryo
Journal of Proteomics, 255, 104501(2022).
- Persistence of Robust Humoral Immune Response in Coronavirus Disease 2019 Convalescent Individuals Over 12 Months After Infection
K.Miyakawa, S.Kubo, S.S.Jeremiah, H.Go, Y.Yamaoka, N.Ohtake, H.Kato, S.Ikeda, T.Mihara, I.Matsuba, N.Sanno, M.Miyakawa, M.Shinkai, T.Miyazaki, T.Ogura, S.Ito, T.Kaneko, K.Yamamoto, A.Goto, A.Ryo
Open Forum Infectious Diseases, 9(2), ofab626(2022).
- All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity
T.Morita, K.Miyakawa, S.S.Jeremiah, Y.Yamaoka, M.Sada, T.Kuniyoshi, J.Yang, H.Kimura, A.Ryo
Viruses, 13(8), 1669(2021).
- 新型冠状病毒抑制剂筛选法的研制及其应用
森田武志、宫川敬、山冈悠太郎、国吉智子、梁明秀
FRAGRANCE JOURNAL, 6, 32-38(2021).
- Rapid detection of neutralizing antibodies to SARS-CoV-2 variants in post-vaccination sera
K.Miyakawa, J.S.Stanleyraj, H.Kato, Y.Yamaoka, H.Go, S.Yajima, T.Shimada, T.Mihara, A.Goto, T.Yamanaka, A.Ryo
Journal of Molecular Cell Biology, mjab050(2021).
- 新型冠状病毒感染症的病情和免疫
久保创介、山冈悠太郎、宫川敬、梁明秀
传染病和预防卫生,5(1),10-17(2021)。
- Combining IL-6 and SARS-CoV-2 RNAaemiabased risk stratification for fatal outcomes of COVID-19
R.Saji, M.Nishii, K.Sakai, K.Miyakawa, Y.Yamaoka, T.Ban, T.Abe, Y.Ohyama, K.Nakajima, T.Hiromi, R.Matsumura, N.Suzuki, H.Taniguchi, T.Otsuka, Y.Oi, F.Ogawa, M.Uchiyama, K.Takahashi, M.Iwashita, Y.Kimura, S.Fujii, R.Furuya, T.Tamura, A.Ryo, I.Takeuchi
PLoSONE 16(8): e0256022(2021).
- Evaluation of a combination protocol of CT-first triage and active telemedicine methods by a selected team tackling COVID-19: An experimental research study
S.Miyake, T.Higurashi, H.Katoa, Y.Yamaoka, T.Kessoku, S.Kato, F.Ogawa, Y.Oia, A.Nakajima, T.Yamamoto, I.Takeuchi, A.Ryoe, S.Maeda
Journal of Infection and Public Health, 14(9), 1212–1217(2021).
- Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests
Y.Yamaoka, K.Miyakawa, S.S.Jeremiah, R.Funabashi, K.Okudela, S.Kikuchi, J.Katada, A.Wada, T.Takei, M.Nishi, K.Shimizu, H.Ozawa, S.Usuku, C.Kawakami, N.Tanaka, T.Morita, H.Hayashi, H.Mitsui, K.Suzuki, D.Aizawa, Y.Yoshimura, T.Miyazaki, E.Yamazaki, T.Suzuki, H.Kimura, H.Shimizu, N.Okabe, H.Hasegawa, A. Ryo
Cell Reports Medicine(2021). doi: 10.1016/j.xcrm.2021.100311
- Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 Survivors
A.Goto, H.Go, K.Miyakawa, Y.Yamaoka, N.Ohtake, S.Kubo, S.S.Jeremiah, T.Mihara, K.Senuki, T.Miyazaki, S.Ikeda, T.Ogura, H.Kato, I.Matsuba, N.Sanno, M.Miyakawa, H.Ozaki, M.Kikuoka, Y.Ohashi, A.Ryo, T.Yamanaka
frontiers in Microbiology(2021). doi: 10.3389/fmicb.2021.661187
- Severe acute respiratory syndrome coronavirus 2 prevalence in saliva and gastric and intestinal fluid in patients undergoing gastrointestinal endoscopy in coronavirus disease 2019 endemic areas: Prospective cross-sectional study in Japan
S.Miyake, K.Ashikari, S.Kato, T.Takatsu, H.Kuwashima, H.Kaneko, K.Nagai, I.Watari, T.Sato, Y.Yamaoka, T.Yamamoto, A.Ryo, S.Maeda, A.Nakajima, T.Higurashi
Digestive Endoscopy(2021), doi: 10.1111/den.13945
- Development of an Automated Chemiluminescence Assay System for Quantitative Measurement of Multiple Anti-SARS-CoV-2 Antibodies
S.Kubo, N.Ohtake, K.Miyakawa, S.Stanleyraj Jeremiah, Y.Yamaoka, K.Murohashi, E.Hagiwara, T.Mihara, A.Goto, E.Yamazaki, T.Ogura, T.Kaneko, T.Yamanaka, A.Ryo
Frontiers in Microbiology, 11, Article 628281(2021).
公立大学法人横滨市立大学新闻稿成功开发出针对新型冠状病毒的4种抗体检测试剂(2020年12月2日)
- Zika virus protease induces caspase-independent pyroptotic cell death by directly cleaving gasdermin D
Y.Yamaoka, S.Matsunaga, SS.Jeremiah, M.Nishi, K.Miyakawa, T.Morita, H.Khatun, H.Shimizu, N.Okabe, H.Kimura, H.Hasegawa, A.Ryo
Biochemical and Biophysical Research Communications, 534 , 666-671(2021).
- Development of Monoclonal Antibodies and Antigen-Capture ELISA for Human Parechovirus Type 3
K.Goto, Y.Yamaoka, H.Khatun, K.Miyakawa, M.Nishi, N.Nagata, T.Yanaoka, H.Kimura, A.Ryo
Microorganisms, 8, 1437(2020).
- Rapid quantitative screening assay for SARS-CoV-2 neutralizing antibodies using HiBiT-tagged virus-like particles
K.Miyakawa, S.S.Jeremiah, N.Ohtake, S.Matsunaga, Y.Yamaoka, M.Nishi, T.Morita, R.Saji, M.Nishii, H.Kimura, H.Hasegawa, I.Takeuchi, A.Ryo
Journal of Mlecular Cell Biology(2020). doi:10.1093/jmcb/mjaa047
公立大学法人横滨市立大学新闻稿成功开发出一种简便、快速测定新型冠状病毒中和抗体的新方法(2020年7月28日)
- Prolyl Isomerase Pin1 Regulates the Stability of Hepatitis B Virus Core Protein
M.Nishi, K.Miyakawa, S.Matsunaga, H.Khatun, Y.Yamaoka, K.Watashi, M.Sugiyama, H.Kimura, T.Wakita, A.Ryo
Frontiers in Cell and Developmental Biology, 8(2020). doi:10.3389/fcell.2020.00026
- Rapid multiplex microfiber-based immunoassay for anti-MERS-CoV antibody detection
C.F.O.Hoy, K.Kushiro, Y.Yamaoka, A.Ryo, M.Takai
Sensing and Bio-Sensing Research, 26, Article 100304(2019).
- Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa associated polyomavirus
H.Khatun, Y.Yamaoka, Y.Matsushima, S.Matsunaga, H.Kimura, J.Ho, M.Shuda, A.Ryo
Microbiology and Immunology, 62(12),763-773(2018).
- Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide
K. Miyakawa, S. Matsunaga, Y. Yamaoka, M. Dairaku, K. Fukano, H. Kimura, T. Chimuro, H. Nishitsuji, K. Watashi, K. Shimotohno, T. Wakita, A. Ryo
Oncotarget, 9(34), 23681-23694 (2018).
- Development of a bench-top extracleanroom for DNA amplification
H. Takahashi, T. Satoh, H. Kanahara, Y. Kubota, T. Hirose, H. Yamazaki, K. Yamamoto, Y. Okamura, T. Suzuki, T. Kobori
BioTechnique, 61(1), 42-46 (2016).
- Discrimination of rat Brunner's gland carbohydrate antigens by site-specific monoclonal antibodies
T. Chimuro, H. Kuroyama, Y. Goso, K. Ishihara, M. Kurihara
Carbohydrate Research, 432, 76-82 (2016).
- Development of Monoclonal Antibody and Diagnostic Test for Middle East Respiratory Syndrome Coronavirus Using Cell-Free Synthesized Nucleocapsid Antigen
Y. Yamaoka, S. Matsuyama, S. Fukushi, S. Matsunaga, Y. Matsushima, H. Kuroyama, H. Kimura, M. Takeda, T. Chimuro, A. Ryo
Frontiers in Microbiology, 7, 509 (2016).
- 面向微生物1细胞基因组分析的全基因组扩增法的改良
高桥宏和、山崎裕之、小堀俊郎
生物科学与工业,72(6),492-493(2014)。
- Preparation of Phi29 DNA Polymerase Free of Amplifiable DNA Using Ethidium Monoazide, an Ultraviolet-Free Light-Emitting Diode Lamp and Trehalose
H. Takahashi, H. Yamazaki, S. Akanuma, H. Kanahara, T. Saito, T. Chimuro, T. Kobayashi, T. Ohtani, K. Yamamoto, S. Sugiyama, T. Kobori
PLOS ONE, 9(2), e82624/1-e82624/9 (2014).
细胞培养相关
- Generation of human-induced pluripotent stem cell-derived functional enterocyte-like cells for pharmacokinetic studies
S.Yoshida, T.Honjo, K.Iino, R.Ishibe, S.Leo, T.Shimada, T.Watanabe, M.Ishikawa, K.Maeda, H.Kusuhara, N.Shiraki, S.Kume
Stem Cell Reports, Vol.16, 1–14(2021).
国立大学法人东京工业大学新闻稿人类iPS细胞成功制作小肠细胞(2021年1月29日)
- A live imaging-friendly slice culture method using collagen membranes
A.Ogaki, T.Araki, M.Ishikawa, Y.Ikegaya, R.Koyama
Neuropsychopharmacology Reports, 40, 307–313(2020).
- Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing
H.Kojima, H.Yamaguchi, T.Sozu, N.Kleinstreuer, L.Chae-Hyung, W.Chen, M.Watanabe, T.Fukuda, K.Yamashita, T.Takezawa
Alternatives to Laboratory Animals, 47(3-4),140-157(2019).
- Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
S.Nakai, I.Shibata, T.Shitamichi, H.Yamaguchi, N.Takagi, T.Inoue, T.Nakagawa, J.Kiyokawa, S.Wakabayashi, T.Miyoshi, E.Higashi, S.Ishida, N.Shiraki, S.Kume
Biology Open , 8, bio042192(2019).
- Fabrication of a corneal model composed of corneal epithelial and endothelial cells via a collagen vitrigel membrane functioned as an acellular stroma and its application to the corneal permeability test of chemicals
H. Yamaguchi, T. Takezawa
Drug Metabolism and Disposition, 46(11), 1684-1691(2018).
- 动物实验替代方法中皮肤评价模型的制作与评价
使用胶原三凝胶膜室的眼刺激性试验法
竹泽俊明、山口宏之
皮肤的安全性、有用性评价法、株式会社技术信息协会、2018、pp. 73-77.
- Predictive performance of the Vitrigel-eye irritancy test method using 118 chemicals
H. Yamaguchi, H. Kojima, T. Takezawa
Journal of Applied Toxicology, 36(8), 1025-1037 (2016).
- Fluid dwell impact induces peritoneal fibrosis in the peritoneal cavity reconstructed in vitro
Aoki, M. Noguchi, T. Takezawa, S. Ikeda, K. Uchihashi, H. Kuroyama, T.Cimuro, S. Toda
Journal of Artificial Organs, 19(1), 87-96 (2016).
- 适合三维培养的新细胞培养用器材ad-MED®
高木信幸
清洁技术,2014(3),71-74(2014)。
诊断试剂相关
- Development of highly sensitive and rapid antigen detection assay for diagnosis of COVID-19 utilizing optical waveguide immunosensor
R.Funabashi, K.Miyakawa, Y.Yamaoka, S.Yoshimura, S.Yamane, J.S.Stanleyraj, K.Shimizu, H.Ozawa, C.Kawakami, S.Usuku, N.Tanaka, E.Yamazaki, H.Kimura, H.Hasegawa, A.Ryo
Journal of Molecular Cell Biology ,mjab037(2021).
- 新型冠状病毒的抗原·抗体检查法
山冈悠太郎、梁明秀
神奈川县公共卫生学会志,第66号(2021)。
- 新型冠状病毒感染症的检查诊断法
山冈悠太郎、梁明秀
感染控制和预防卫生,4(1),9-15(2020)。
微生物检查相关
- 不需要厌氧培养C。Diff选择增菌培养基的性能评价
大川内沙织、名取达矢、内田宣邦、新井惠理子、堀内一树
日本临床微生物学会杂志,32(4),63-66(2022)。
电泳相关/其他
- 蛋白质检测用荧光分子探针的创制和向高通量检测法的展开
铃木祥夫、高木信幸
生物物理化学,58(2),65-67(2014)。
有机合成·催化剂关联
- Asymmetric Reductive Amination of α‑Keto Acids Using Ir-Based Hydrogen Transfer Catalysts: An Access to Unprotected Unnatural α‑Amino Acids
T.Yajima, A.Katayama, T.Ito, T.Kawada, K.Yabushita, T.Yasuda, T.Ohta, T.Katayama, N.Utsumi, Y.Kayaki, S.Kuwata
Organic Letters, 26(7), 1426−1431(2024). https://doi.org/10.1021/acs.orglett.3c04378
- Apparatus for ammonia removal in livestock farms based on copper hexacyanoferrate granules
K.Minami , A.Takahashi, K.Sakurai, H.Mikasa, M.Takasaki, N.Doshu, K.Aoyama, T.Nakamura, R.IaIwai, T.Kawamoto
Biosystems Engineering, 216, 98-107(2022).
- Asymmetric Transfer Hydrogenative Amination of Benzylic Ketones Catalyzed by Cp*Ir(III) Complexes Bearing a ChiralN-(2-Picolyl)sulfonamidato Ligand
T.Kawada, K.Yabushita, T.Yasuda, T.Ohta, T.Yajima, K.Tanaka, N.Utsumi, M.Watanabe, K.Murata, Y.Kayaki, S.Kuwata, and T.Katayama
The Journal of Organic Chemistry, 87(13), 8458-8468(2022) doi;10.1021/acs.joc.2c00580
- Double-Helix Supramolecular Nanofibers Assembled from Negatively Curved Nanographenes
K.Kato, K.Takaba, S.M-Yonekura, N.Mitoma, Y.Nakanishi, T.Nishihara, T.Hatakeyama, T.Kawada, Y.Hijikata, J.Pirillo, L.T. Scott, K.Yonekura, Y.Segawa, K.Itami
Journal of The American Chemical Society, doi;10.1021/jacs.1c00863
- Reductive Amination of Ketonic Compounds Catalyzed by Cp*Ir(III) Complexes Bearing a Picolinamidato Ligand
K.Tanaka, T.Miki, K.Murata, A.Yamaguchi, Y.Kayaki, S.Kuwata, T.Ikariya, M.Watanabe
The Journal of Organic Chemistry, 84, 10962-10977(2019).
- Asymmetric Hydrogenation of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos/PICA Derivative–Ruthenium(II) Complexes
N.Utsumi, N.Arai, K.Kawaguchi, T.Katayama, T.Yasuda, K.Murata, T.Ohkuma
ChemCatChem, 10(18), 3955-3959, 2018.
- Computationally-Led Ligand Modification using Interplay between Theory and Experiments: Highly Active Chiral Rhodium Catalyst Controlled by Electronic Effects and CH-π Interactions
T. Korenaga, R. Sasaki, T. Takemoto, T. Yasuda, M. Watanabe
Advanced Synthesis & Catalysis, 360, 322-333,(2018).
- Palladium-Catalyzed Decarbonylative Cross-Coupling of Azinecarboxylates with Arylboronic Acids
K. Muto, T. Hatakeyama, K. Itami, J. Yamaguchi
Organic Letters, 18(19), 5106-5109 (2016).
- C-H arylation and alkenylation of imidazoles by nickel catalysis : solvent-accelerated imidazole C-H activation
K. Muto, T. Hatakeyama, J. Yamaguchi, K. Itami
Chemical Science, 6, 6792-6798 (2015).
- Hydrogenation of nitroarenes with palladium nanoparticles stabilized by alkyne derivatives in homogeneous phase
N. Arai, N. Onodera, A. Dekita, J. Hori, T. Ohkuma
Tetrahedron Letters, 56(25), 3913-3915 (2015).
有机材料相关
- 离子性高分子胶凝剂的开发
高桥崎干大
月度精细化学,45(10),47-55(2016)。
- Novel Hole-Transporting Materials with High Triplet Energy for Highly Efficient and Stable Organic Light-Emitting Diodes
H. Fukagawa, T. Shimizu, H. Kawano, S. Yui, T. Shinnnai, A. Iwai, K. Tsuchiya, T. Yamamoto
The Jounal of Physical Chemistry C, 120(33), 18748-18755 (2016).
电子工业用药品相关
无机材料关联
- 将用聚乙烯醇造粒铁氰化铜用于Cs吸附材料的离子色谱法对137Cs浓缩飞灰的去污
市川恒树、山田一夫、岩井良太、金泽幸广
环境放射能除污学会志,8(2),55-66(2020)。
- Analysis of Cs-adsorption behavior using a column filled with microcapsule beads of potassium copper hexacyanoferrate
G. Kido, M. Takasaki, K. Minami, H. Tanaka, H. Ogawa, T. Kawamoto, K. Yoshino
Journal of nuclear science and technology, 54(11), 1157-1162 (2017).
- Decomposition of Iron Hexacyabnoferrate Microcapsule Beads Using Superheated Steam
K. M. Lee, M. Asai, T. Uchida, T. Kawamoto, K. Minami, A. Takahashi, D. Parajuli, G. Kido, M. Takasaki, K. Yoshino, H. Tanaka
Chemistry Letters, 45(6), 670-672 (2016).
- Improved adsorption properties of granulated copper hexacyanoferrate with multi-scale porous networks
K. M. Lee, T. Kawamoto, K. Minami, A. Takahashi, D. Parajuli, G. Kido, K. Yoshino, H. Tanaka
RSC Advances, 6, 16234-16238 (2016).
- Comparative study of the factors associated with the application of metal hexacyanoferrates for environmental Cs decontamination
D. Parajuli, A. Takahashi, H. Noguchi, A. Kitajima, H. Tanaka, M. Takasaki, K. Yoshino, T. Kawamoto
Chemical Engineering Journal, 283, 1322-1328 (2016).
- Application of Prussian blue nanoparticles for the radioactive Cs decontamination in Fukushima region
D.Parajuli, A.Kitajima, A.Takahashi, H.Tanaka, H.Ogawa, Y.Hakuta, K.Yoshino, T.Funahashi, M.Yamaguchi, M.Osada, T.Kawamoto
Journal of Environmental Radioactivity, 151, 233-237 (2016).
- Prussian blue (PB) granules for cesium (Cs) removal from drinking water
G. Ru. Chen, Y. R. Chang, X. Liu, T. Kawamoto, H. Tanaka, A. Kitajima, D. Parajuli, M. Takasaki, K. Yoshino, M. L. Chen, Y. K. Lo, Z. Lei, D. J. Lee
Separation and Purification Technology, 143, 146-151 (2015).