关东化学株式会社 > 研究开发>研究发表/论文

研究发表/论文

本公司在各个领域与大学、公共机关、企业一起积极推进共同研究,并在论文等中发表了其成果。关于近年来的发表,我来介绍一下其中的一部分。

基因工程相关/其他

  • Generation and Utilization of a Monoclonal Antibody against Hepatitis B Virus Core Protein for a Comprehensive Interactome Analysis
    Y.Nakai, K.Miyakawa, Y.Yamaoka, Y. Hatayama, M.Nishi, H.Suzuki, H.Kimura, H.Takahashi, Y.Kimura, A.Ryo
    Microorganisms, 10, 2381(2022).
  • Development of a Monoclonal Antibody Targeting HTLV-1 Envelope gp46 Glycoprotein and Its Application to Near-Infrared Photoimmuno-Antimicrobial Strategy
    Y. Hatayama, Y.Yamaoka, T.Morita, S.S.Jeremiah, K.Miyakawa, M.Nishi, Y.Kimura, M.Mitsunaga, T.Iwase, H.Kimura, N.Yamamoto, A.Takaori-Kondo, H.Hasegawa, A.Ryo
    Viruses, 14, 2153 (2022).
  • Development of Parallel Reaction Monitoring Mass Spectrometry Assay for the Detection of Human Norovirus Major Capsid Protein
    Y.Kimura, J.Shin, Y.Nakai, M.Takahashi, Y.Ino, T.Akiyama, K.Goto, N.Nagata, Y.Yamaoka, K.Miyakawa, H.Kimura, A.Ryo
    Viruses, 14(7), 1416(2022).
  • Characterization and Utilization of Disulfide-Bonded SARS-CoV-2 Receptor Binding Domain of Spike Protein Synthesized by Wheat Germ Cell-Free Production System
    Y.Yamaoka, S.S.Jeremiah, R.Funabashi, K.Miyakawa, T.Morita, Y.Mihana, H.Kato, A.Ryo
    Viruses, 14(7), 1461(2022).
  • Vaccine-induced humoral response against SARS-CoV-2 dramatically declined but cellular immunity possibly remained at 6 months post BNT162b2 vaccination
    H.Kato, K.Miyakawa, N.Ohtake, Y.Yamaoka, S.Yajima, E.Yamazaki, T.Shimada, A.Goto, H.Nakajima, A.Ryo
    Vaccine, 40, 2652–2655(2022).
  • Molecular and Epidemiological Characterization of Emerging Immune-Escape Variants of SARS-CoV-2
    K.Miyakawa, S.S.Jeremiah, Y.Yamaoka, T.Koyama, R.Tokumasu, M.Kudo, H.Kato, A.Ryo
    frontiers in Medicine, 10(2022).
  • 针对新型冠状病毒感染症的抗原检查法
    山冈悠太郎、宫川敬、森田武志、梁明秀
    感染控制和预防卫生,5(2),8-14(2021)。
  • Antibody titers against the Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2 induced by BNT162b2 vaccination measured using automated chemiluminescent enzyme immunoassay
    H.Kato, K.Miyakawa, N.Ohtake, H.Go, Y.Yamaoka, S.Yajima, T.Shimada, A.Goto, H.Nakajima, A.Ryo
    Journal of Infection and Chemotherapy, 28, 273–278(2022).
  • Phosphopeptide enrichment using Phos-tag technology reveals functional phosphorylation of the nucleocapsid protein of SARS-CoV-2
    Y.Ino, M.Nishi, Y.Yamaoka, K.Miyakawa, S.S.Jeremiah, M.Osada, Y.Kimura, A.Ryo
    Journal of Proteomics, 255, 104501(2022).
  • Persistence of Robust Humoral Immune Response in Coronavirus Disease 2019 Convalescent Individuals Over 12 Months After Infection
    K.Miyakawa, S.Kubo, S.S.Jeremiah, H.Go, Y.Yamaoka, N.Ohtake, H.Kato, S.Ikeda, T.Mihara, I.Matsuba, N.Sanno, M.Miyakawa, M.Shinkai, T.Miyazaki, T.Ogura, S.Ito, T.Kaneko, K.Yamamoto, A.Goto, A.Ryo
    Open Forum Infectious Diseases, 9(2), ofab626(2022).
  • All-Trans Retinoic Acid Exhibits Antiviral Effect against SARS-CoV-2 by Inhibiting 3CLpro Activity
    T.Morita, K.Miyakawa, S.S.Jeremiah, Y.Yamaoka, M.Sada, T.Kuniyoshi, J.Yang, H.Kimura, A.Ryo
    Viruses, 13(8), 1669(2021).
  • 新型冠状病毒抑制剂筛选法的研制及其应用
    森田武志、宫川敬、山冈悠太郎、国吉智子、梁明秀
    FRAGRANCE JOURNAL, 6, 32-38(2021).
  • Rapid detection of neutralizing antibodies to SARS-CoV-2 variants in post-vaccination sera
    K.Miyakawa, J.S.Stanleyraj, H.Kato, Y.Yamaoka, H.Go, S.Yajima, T.Shimada, T.Mihara, A.Goto, T.Yamanaka, A.Ryo
    Journal of Molecular Cell Biology, mjab050(2021).
  • 新型冠状病毒感染症的病情和免疫
    久保创介、山冈悠太郎、宫川敬、梁明秀
    传染病和预防卫生,5(1),10-17(2021)。
  • Combining IL-6 and SARS-CoV-2 RNAaemiabased risk stratification for fatal outcomes of COVID-19
    R.Saji, M.Nishii, K.Sakai, K.Miyakawa, Y.Yamaoka, T.Ban, T.Abe, Y.Ohyama, K.Nakajima, T.Hiromi, R.Matsumura, N.Suzuki, H.Taniguchi, T.Otsuka, Y.Oi, F.Ogawa, M.Uchiyama, K.Takahashi, M.Iwashita, Y.Kimura, S.Fujii, R.Furuya, T.Tamura, A.Ryo, I.Takeuchi
    PLoSONE 16(8): e0256022(2021).
  • Evaluation of a combination protocol of CT-first triage and active telemedicine methods by a selected team tackling COVID-19: An experimental research study
    S.Miyake, T.Higurashi, H.Katoa, Y.Yamaoka, T.Kessoku, S.Kato, F.Ogawa, Y.Oia, A.Nakajima, T.Yamamoto, I.Takeuchi, A.Ryoe, S.Maeda
    Journal of Infection and Public Health, 14(9), 1212–1217(2021).
  • Highly specific monoclonal antibodies and epitope identification against SARS-CoV-2 nucleocapsid protein for antigen detection tests
    Y.Yamaoka, K.Miyakawa, S.S.Jeremiah, R.Funabashi, K.Okudela, S.Kikuchi, J.Katada, A.Wada, T.Takei, M.Nishi, K.Shimizu, H.Ozawa, S.Usuku, C.Kawakami, N.Tanaka, T.Morita, H.Hayashi, H.Mitsui, K.Suzuki, D.Aizawa, Y.Yoshimura, T.Miyazaki, E.Yamazaki, T.Suzuki, H.Kimura, H.Shimizu, N.Okabe, H.Hasegawa, A. Ryo
    Cell Reports Medicine(2021).  doi: 10.1016/j.xcrm.2021.100311
  • Sustained Neutralizing Antibodies 6 Months Following Infection in 376 Japanese COVID-19 Survivors
    A.Goto, H.Go, K.Miyakawa, Y.Yamaoka, N.Ohtake, S.Kubo, S.S.Jeremiah, T.Mihara, K.Senuki, T.Miyazaki, S.Ikeda, T.Ogura, H.Kato, I.Matsuba, N.Sanno, M.Miyakawa, H.Ozaki, M.Kikuoka, Y.Ohashi, A.Ryo, T.Yamanaka
    frontiers in Microbiology(2021). doi: 10.3389/fmicb.2021.661187
  • Severe acute respiratory syndrome coronavirus 2 prevalence in saliva and gastric and intestinal fluid in patients undergoing gastrointestinal endoscopy in coronavirus disease 2019 endemic areas: Prospective cross-sectional study in Japan
    S.Miyake, K.Ashikari, S.Kato, T.Takatsu, H.Kuwashima, H.Kaneko, K.Nagai, I.Watari, T.Sato, Y.Yamaoka, T.Yamamoto, A.Ryo, S.Maeda, A.Nakajima, T.Higurashi
    Digestive Endoscopy(2021), doi: 10.1111/den.13945
  • Development of Monoclonal Antibodies and Antigen-Capture ELISA for Human Parechovirus Type 3
    K.Goto, Y.Yamaoka, H.Khatun, K.Miyakawa, M.Nishi, N.Nagata, T.Yanaoka, H.Kimura, A.Ryo
    Microorganisms, 8, 1437(2020).
  • Rapid multiplex microfiber-based immunoassay for anti-MERS-CoV antibody detection
    C.F.O.Hoy, K.Kushiro, Y.Yamaoka, A.Ryo, M.Takai
    Sensing and Bio-Sensing Research, 26, Article 100304(2019).
  • Production and characterization of monoclonal antibodies specific for major capsid VP1 protein of trichodysplasia spinulosa associated polyomavirus
    H.Khatun, Y.Yamaoka, Y.Matsushima, S.Matsunaga, H.Kimura, J.Ho, M.Shuda, A.Ryo
    Microbiology and Immunology, 62(12),763-773(2018).
  • Development of a cell-based assay to identify hepatitis B virus entry inhibitors targeting the sodium taurocholate cotransporting polypeptide
    K. Miyakawa, S. Matsunaga, Y. Yamaoka, M. Dairaku, K. Fukano, H. Kimura, T. Chimuro, H. Nishitsuji, K. Watashi, K. Shimotohno, T. Wakita, A. Ryo
    Oncotarget, 9(34), 23681-23694 (2018).
  • Development of a bench-top extracleanroom for DNA amplification
    H. Takahashi, T. Satoh, H. Kanahara, Y. Kubota, T. Hirose, H. Yamazaki, K. Yamamoto, Y. Okamura, T. Suzuki, T. Kobori
    BioTechnique, 61(1), 42-46 (2016).
  • Discrimination of rat Brunner's gland carbohydrate antigens by site-specific monoclonal antibodies
    T. Chimuro, H. Kuroyama, Y. Goso, K. Ishihara, M. Kurihara
    Carbohydrate Research, 432, 76-82 (2016).
  • Development of Monoclonal Antibody and Diagnostic Test for Middle East Respiratory Syndrome Coronavirus Using Cell-Free Synthesized Nucleocapsid Antigen
    Y. Yamaoka, S. Matsuyama, S. Fukushi, S. Matsunaga, Y. Matsushima, H. Kuroyama, H. Kimura, M. Takeda, T. Chimuro, A. Ryo
    Frontiers in Microbiology, 7, 509 (2016).
  • 面向微生物1细胞基因组分析的全基因组扩增法的改良
    高桥宏和、山崎裕之、小堀俊郎
    生物科学与工业,72(6),492-493(2014)。
  • Preparation of Phi29 DNA Polymerase Free of Amplifiable DNA Using Ethidium Monoazide, an Ultraviolet-Free Light-Emitting Diode Lamp and Trehalose
    H. Takahashi, H. Yamazaki, S. Akanuma, H. Kanahara, T. Saito, T. Chimuro, T. Kobayashi, T. Ohtani, K. Yamamoto, S. Sugiyama, T. Kobori
    PLOS ONE, 9(2), e82624/1-e82624/9 (2014).

细胞培养相关

  • A live imaging-friendly slice culture method using collagen membranes
    A.Ogaki, T.Araki, M.Ishikawa, Y.Ikegaya, R.Koyama
    Neuropsychopharmacology Reports, 40, 307–313(2020).
  • Multi-laboratory Validation Study of the Vitrigel-Eye Irritancy Test Method as an Alternative to In Vivo Eye Irritation Testing
    H.Kojima, H.Yamaguchi, T.Sozu, N.Kleinstreuer, L.Chae-Hyung, W.Chen, M.Watanabe, T.Fukuda, K.Yamashita, T.Takezawa
    Alternatives to Laboratory Animals, 47(3-4),140-157(2019).
  • Collagen vitrigel promotes hepatocytic differentiation of induced pluripotent stem cells into functional hepatocyte-like cells
    S.Nakai, I.Shibata, T.Shitamichi, H.Yamaguchi, N.Takagi, T.Inoue, T.Nakagawa, J.Kiyokawa, S.Wakabayashi, T.Miyoshi, E.Higashi, S.Ishida, N.Shiraki, S.Kume
    Biology Open , 8, bio042192(2019).
  • Fabrication of a corneal model composed of corneal epithelial and endothelial cells via a collagen vitrigel membrane functioned as an acellular stroma and its application to the corneal permeability test of chemicals
    H. Yamaguchi, T. Takezawa
    Drug Metabolism and Disposition, 46(11), 1684-1691(2018).
  • 动物实验替代方法中皮肤评价模型的制作与评价
    使用胶原三凝胶膜室的眼刺激性试验法

    竹泽俊明、山口宏之
    皮肤的安全性·有用性评价法、株式会社技术信息协会、2018、pp.73-77。
  • Predictive performance of the Vitrigel-eye irritancy test method using 118 chemicals
    H. Yamaguchi, H. Kojima, T. Takezawa
    Journal of Applied Toxicology, 36(8), 1025-1037 (2016).
  • Fluid dwell impact induces peritoneal fibrosis in the peritoneal cavity reconstructed in vitro
    Aoki, M. Noguchi, T. Takezawa, S. Ikeda, K. Uchihashi, H. Kuroyama, T.Cimuro, S. Toda
    Journal of Artificial Organs, 19(1), 87-96 (2016).
  • 适合三维培养的新细胞培养用器材ad-MED®
    高木信幸
    清洁技术,2014(3),71-74(2014)。

诊断试剂相关

  • Development of highly sensitive and rapid antigen detection assay for diagnosis of COVID-19 utilizing optical waveguide immunosensor
    R.Funabashi, K.Miyakawa, Y.Yamaoka, S.Yoshimura, S.Yamane, J.S.Stanleyraj, K.Shimizu, H.Ozawa, C.Kawakami, S.Usuku, N.Tanaka, E.Yamazaki, H.Kimura, H.Hasegawa, A.Ryo
    Journal of Molecular Cell Biology ,mjab037(2021).
  • 新型冠状病毒的抗原·抗体检查法
    山冈悠太郎、梁明秀
    神奈川县公共卫生学会志,第66号(2021)。
  • 新型冠状病毒感染症的检查诊断法
    山冈悠太郎、梁明秀
    感染控制和预防卫生,4(1),9-15(2020)。
  • 尿中儿茶酚胺类及其代谢物中酸性蓄尿用添加剂“酸性百合主要·T”的适用评价
    中浦秀章、加藤雅子、粗恭子、高笠信之
    THE CHEMICAL TIMES, 231, 13-17 (2014).

微生物检查相关

  • 不需要厌氧培养C。Diff选择增菌培养基的性能评价
    大川内沙织、名取达矢、内田宣邦、新井惠理子、堀内一树
    日本临床微生物学会杂志,32(4),63-66(2022)。

电泳相关/其他

  • 蛋白质检测用荧光分子探针的创制和向高通量检测法的展开
    铃木祥夫、高木信幸
    生物物理化学,58(2),65-67(2014)。

有机合成·催化剂关联

  • Apparatus for ammonia removal in livestock farms based on copper hexacyanoferrate granules
    K.Minami , A.Takahashi, K.Sakurai, H.Mikasa, M.Takasaki, N.Doshu, K.Aoyama, T.Nakamura, R.IaIwai, T.Kawamoto
    Biosystems Engineering, 216, 98-107(2022).
  • Asymmetric Transfer Hydrogenative Amination of Benzylic Ketones Catalyzed by Cp*Ir(III) Complexes Bearing a ChiralN-(2-Picolyl)sulfonamidato Ligand
    T.Kawada, K.Yabushita, T.Yasuda, T.Ohta, T.Yajima, K.Tanaka, N.Utsumi, M.Watanabe, K.Murata, Y.Kayaki, S.Kuwata, and T.Katayama
    The Journal of Organic Chemistry, 87(13), 8458-8468(2022) doi;10.1021/acs.joc.2c00580
  • Double-Helix Supramolecular Nanofibers Assembled from Negatively Curved Nanographenes
    K.Kato, K.Takaba, S.M-Yonekura, N.Mitoma, Y.Nakanishi, T.Nishihara, T.Hatakeyama, T.Kawada, Y.Hijikata, J.Pirillo, L.T. Scott, K.Yonekura, Y.Segawa, K.Itami
    Journal of The American Chemical Society, doi;10.1021/jacs.1c00863
  • Reductive Amination of Ketonic Compounds Catalyzed by Cp*Ir(III) Complexes Bearing a Picolinamidato Ligand
    K.Tanaka, T.Miki, K.Murata, A.Yamaguchi, Y.Kayaki, S.Kuwata, T.Ikariya, M.Watanabe
    The Journal of Organic Chemistry, 84, 10962-10977(2019).
  • Asymmetric Hydrogenation of Polysubstituted Aromatic Ketones Catalyzed by the DIPSkewphos/PICA Derivative–Ruthenium(II) Complexes
    N.Utsumi, N.Arai, K.Kawaguchi, T.Katayama, T.Yasuda, K.Murata, T.Ohkuma
    ChemCatChem, 10(18), 3955-3959, 2018.
  • Computationally-Led Ligand Modification using Interplay between Theory and Experiments: Highly Active Chiral Rhodium Catalyst Controlled by Electronic Effects and CH-π Interactions
    T. Korenaga, R. Sasaki, T. Takemoto, T. Yasuda, M. Watanabe
    Advanced Synthesis & Catalysis, 360, 322-333,(2018).
  • Palladium-Catalyzed Decarbonylative Cross-Coupling of Azinecarboxylates with Arylboronic Acids
    K. Muto, T. Hatakeyama, K. Itami, J. Yamaguchi
    Organic Letters, 18(19), 5106-5109 (2016).
  • C-H arylation and alkenylation of imidazoles by nickel catalysis : solvent-accelerated imidazole C-H activation
    K. Muto, T. Hatakeyama, J. Yamaguchi, K. Itami
    Chemical Science, 6, 6792-6798 (2015).
  • Hydrogenation of nitroarenes with palladium nanoparticles stabilized by alkyne derivatives in homogeneous phase
    N. Arai, N. Onodera, A. Dekita, J. Hori, T. Ohkuma
    Tetrahedron Letters, 56(25), 3913-3915 (2015).

有机材料相关

  • 离子性高分子胶凝剂的开发
    高桥崎干大
    月度精细化学,45(10),47-55(2016)。
  • Novel Hole-Transporting Materials with High Triplet Energy for Highly Efficient and Stable Organic Light-Emitting Diodes
    H. Fukagawa, T. Shimizu, H. Kawano, S. Yui, T. Shinnnai, A. Iwai, K. Tsuchiya, T. Yamamoto
    The Jounal of Physical Chemistry C, 120(33), 18748-18755 (2016).

电子工业用药品相关

无机材料关联

  • 将用聚乙烯醇造粒铁氰化铜用于Cs吸附材料的离子色谱法对137Cs浓缩飞灰的去污
    市川恒树、山田一夫、岩井良太、金泽幸广
    环境放射能除污学会志,8(2),55-66(2020)。
  • Analysis of Cs-adsorption behavior using a column filled with microcapsule beads of potassium copper hexacyanoferrate
    G. Kido, M. Takasaki, K. Minami, H. Tanaka, H. Ogawa, T. Kawamoto, K. Yoshino
    Journal of nuclear science and technology, 54(11), 1157-1162 (2017).
  • Decomposition of Iron Hexacyabnoferrate Microcapsule Beads Using Superheated Steam
    K. M. Lee, M. Asai, T. Uchida, T. Kawamoto, K. Minami, A. Takahashi, D. Parajuli, G. Kido, M. Takasaki, K. Yoshino, H. Tanaka
    Chemistry Letters, 45(6), 670-672 (2016).
  • Improved adsorption properties of granulated copper hexacyanoferrate with multi-scale porous networks
    K. M. Lee, T. Kawamoto, K. Minami, A. Takahashi, D. Parajuli, G. Kido, K. Yoshino, H. Tanaka
    RSC Advances, 6, 16234-16238 (2016).
  • Comparative study of the factors associated with the application of metal hexacyanoferrates for environmental Cs decontamination
    D. Parajuli, A. Takahashi, H. Noguchi, A. Kitajima, H. Tanaka, M. Takasaki, K. Yoshino, T. Kawamoto
    Chemical Engineering Journal, 283, 1322-1328 (2016).
  • Application of Prussian blue nanoparticles for the radioactive Cs decontamination in Fukushima region
    D.Parajuli, A.Kitajima, A.Takahashi, H.Tanaka, H.Ogawa, Y.Hakuta, K.Yoshino, T.Funahashi, M.Yamaguchi, M.Osada, T.Kawamoto
    Journal of Environmental Radioactivity, 151, 233-237 (2016).
  • Prussian blue (PB) granules for cesium (Cs) removal from drinking water
    G. Ru. Chen, Y. R. Chang, X. Liu, T. Kawamoto, H. Tanaka, A. Kitajima, D. Parajuli, M. Takasaki, K. Yoshino, M. L. Chen, Y. K. Lo, Z. Lei, D. J. Lee
    Separation and Purification Technology, 143, 146-151 (2015).