Prototype reductionglutathione（Glutathione），Chemical nameN - (N-L-γ-Glutamyl-L-cysteine)glycine, the molecular formula is CtenHseventeenNthreeOsixS. With a molecular weight of 307.33, it is soluble in water, dilute alcohol, liquid ammonia and methylFormamide, but insoluble in alcohol, ether andacetone。
Chinese name
Reduced glutathione
Foreign name
Glutathione
Alias
G-SH
chemical formula
CtenHseventeenNthreeOsixS
molecular weight
three hundred and seven point three two three
CAS login number
70-18-8
EINECS login number
200-725-4
Melting point
192 to 195 ℃
Water solubility
50 mg/mL
Density
1.441 g/cm³
Appearance
White powder
Security description
S24/25
Hazard symbol
R68
Hazard description
Xi
PSA
one hundred and ninety-seven point six two zero zero zero
Precision quality
three hundred and seven point zero eight four zero zero
adultCommon quantityTake 400mg (4 tablets) orally three times a day.The course of treatment was 12 weeks.
Adverse reactions
one
Allergy: The drug should be stopped if there are allergic symptoms such as rash occasionally.
two
Occasionally, there are symptoms of anorexia, nausea, vomiting, epigastric pain, etc.
taboo
People who are allergic to the ingredients of this product should not use it.
matters needing attention
Keep out of the reach of children.
Drugs for pregnant and lactating women
miceandrabbitGlutathione was given intravenously during pregnancy, and no reproduction was foundToxic reaction。This product is good for pregnant women andLactating womenThe impact of is not yet clear.
glutathioneIt is composed of glutamic acidCystineAnd glycine, which isGlyceraldehydeaciddehydrogenaseOfCofactor, againGlyoxalaseandTriose phosphateDehydrogenasecoenzyme, participate in the tricarboxylic acid cycle andCarbohydrate metabolismSo that the human body can obtain high energy.Glutathione can activate many enzymes, such asMercapto group(- SH) enzymes, coenzymes, etc., to promote sugar, fatprotein metabolism It can also affect the metabolic process of cells, and is an important regulatory metabolite in cells.In addition, glutathione is reduced into glutathione (GSH) andOxidized glutathione(GSSG) exists in two forms, and its active ingredient is reduced glutathione, which can participate in the bodyRedoxProcess.Under the action of glutathione transferase, reduced glutathione canperoxideAnd free radicals toantioxidantDamage to sulfhydryl group, protectioncell membraneSulfhydrylproteinAnd sulfhydryl containing enzymes will not be destroyed, but also resist the damage of free radicals to important organs.Glutathione widely exists in animalsplant cellInside, in the liver andLensHigh content in.It can now be chemically synthesized orFermentationProduction.Glutathione is glyceraldehydephosphoric acidThe coenzyme of dehydrogenase is also the coenzyme of glyoxalase and triose phosphate dehydrogenase, participating in the tricarboxylic acid cycle and sugar metabolism in the body, so that the human body can obtain high energy.It can activate and protect various enzymes, such ascholinesteraseIsomercapto (- SH) enzyme, which protects the body fromIodoacetic acid、Mustard gasFree radicals (such assuperoxide anion ）, heavy metals (such as mercury and lead)EpoxideThe toxicity of harmful substances, such as, can promote the metabolism of sugar, fat and protein, and also affect the metabolic process of cells.Promote the metabolism of eye tissue and inhibitCrystallinThe instability of thiol group prevents cataracts andRetinal diseasesSo it can be used for keratitisCorneal traumaEtc.For this kind of diseaseSenile periodThis kind of antioxidant is often used before, which can play a preventive role.At the same time, it also has a good effect of increasing vision.
Pharmacokinetics
Reduced glutathione is a physiological factor with extensive physiological effectscytoplasmEndosynthesis, especially liver synthesis, is also the main metabolism, and is widely distributed in various organs of the bodyCellular organismFunction plays an important role.Animal pharmacology test suggests reduced glutathioneintravenous injectionAfter 5hBlood concentrationIt reaches the peak, and can be measured in liver, kidney, muscle and other tissues one hour after injection, and small doses can be found in the brain,half life24h.Mainly fromRenal excretion, viaglomerulusDirect filtration and utilizationγ-glutamineTranspeptide reactionThere are two ways of non filtration mechanism of renal clearance.
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glutathioneIt is a kind of physiological factor with extensive functions, which is composed ofglutamate、CysteineandglycineConstituentTripeptide, widely distributed in various organs of the bodyphysiological functionAspect plays an important role.The active ingredient of this product is reduced glutathione, which can participate in the bodyTricarboxylic acid cycle, activate various enzymesMercapto groupyesinhibitionTo inhibitcataractTo inhibit the development of cornea andRetinopathy, can promoteEpithelial tissueRepair of.This product is clinically used to protect the liver.This medicineCan inhibitFatty liverFormation can also be improvedToxic hepatitisandInfectivitySymptoms of hepatitis.This medicine also has the detoxification function, which can interact with the electrophilic group andFree radicaletc.Hazardous substancesThe combination can produce the effect of detoxification and cell protection.Animal experimentIt shows that glutathione can reduceCisplatinCaused byRenal dysfunctionandneurotoxicity。Four groups of small-scale second or third stage randomization have been conductedclinical research , using differentDosing schemeThe conclusions are also different.Research shows that glutathione is reducedChemotherapy drugsThe toxic effect has clinical significance.However, it is still necessary to carry out appropriate scaletumourThe research ofAdministrationThe scheme has not been determined yet, but cisplatin is injected for 30min, and glutathione is injected 15 minutes before cisplatin administration, and then 72 hours laterIntramuscular injectionThis medicine is worth further study.
