Collection

zero Useful+1

zero

Iodoacetic acid

Organic compound

This entry is made by Compilation and application of scientific encyclopedia entries of "Science Popularization China" to examine.

Iodine acetic acid, an organic compound, chemical formula C two H three IO two , a white crystalline powder, soluble in water, hot petroleum ether, ethanol, insoluble in ether, chloroform, used as an analytical reagent, dye preparation, organic synthesis and enzyme inhibitor.

Chinese name: Iodoacetic acid
Foreign name: Iodoacetic acid
chemical formula: C two H three IO two
molecular weight: one hundred and eighty-five point nine four eight
CAS login number: 64-69-7
EINECS login number: 200-590-1
Melting point: 79 ℃
Water solubility: soluble

Density: 2.27 g/cm ³
Appearance: White crystalline powder
Security description: S22； S36/37/39； S45
Hazard symbol: T； C
Hazard description: R25； R35
MDL No: MFCD00002685
RTECS No: AI3500000
BRN No: one million seven hundred and thirty-nine thousand and seventy-nine
PubChem No: two million four hundred and eighty-nine thousand six hundred and five

catalog

Physical and chemical properties

Announce

edit

Melting point: 79 ℃

Density: 2.27g/cm three

Appearance: white crystalline powder

Solubility: soluble in water, hot petroleum ether, ethanol, insoluble in ether, chloroform

Molecular structure data

Announce

edit

Molar refractive index: 25.84

Molar volume (cm three /mol）：75.0

Isotonic specific volume (90.2K): 207.5

Surface tension (dyne/cm): 58.5

Polarization (10 -24 cm three ）：10.24^[1]

Calculate chemical data

Announce

edit

Reference value for drainage parameter calculation (XlogP): 0.5

Number of hydrogen bond donors: 1

Number of hydrogen bond receptors: 2

Number of rotatable chemical bonds: 1

Number of tautomers: 0

Topological molecular polar surface area: 37.3

Number of heavy atoms: 5

Surface charge: 0

Complexity: 42.9

Number of isotope atoms: 0

Determine the number of atomic structure centers: 0

Number of uncertain atomic structure centers: 0

Determine the number of chemical bond structure centers: 0

Number of uncertain chemical bond structure centers: 0

Number of covalent bond units: 1^[1]

toxicology data

Announce

edit

1. Acute toxicity

LD fifty : 83mg/kg (rat by mouth); 75mg/kg (rat abdominal cavity); 83mg/kg (mouse by mouth).

2. Subacute and chronic toxicity: rats were fed with feed containing this product at a dose of 50~70mg/(kg · d), and died within 10~40d.

3. Mutagenicity

DNA inhibition: human Hela cell 500 μ mol/L。

Cytogenetic analysis: hamster fibroblast 100 μ g/L。

4. Teratogenicity: The lowest toxic dose of 158mg/kg was administered orally to male mice before mating, resulting in craniofacial (including nose and tongue) malformations. Female mice were administered 40mg/kg intraperitoneally on the 8th day after pregnancy, resulting in malformation of musculoskeletal system.

5. Carcinogenicity: the lowest dermal toxic dose (TDLo) of mice: 5800mg/kg (27 weeks), causing tumors, skin tumors, and tumors at the application site.

6. Others: The lowest intraperitoneal toxic dose (TDLo) of mice: 40g/kg (8 days of pregnancy), resulting in abnormal musculoskeletal development.

Storage method

Announce

edit

Store in a cool and ventilated warehouse. Keep away from kindling and heat sources. Packing and sealing. It shall be stored separately from oxidants, reducing agents, alkalis and edible chemicals, and mixed storage is strictly prohibited. Equip with corresponding types and quantities of fire-fighting equipment. The storage area shall be equipped with appropriate materials to contain leakage.^[1-2]

purpose

Announce

edit

Used as analytical reagent, dye preparation, organic synthesis and enzyme inhibitor.

Leakage emergency treatment

Announce

edit

Isolate the leakage contaminated area, set up warning signs around it, and suggest emergency treatment personnel to wear gas masks and chemical protective clothing. Do not contact with the leakage directly. Collect it in a dry, clean and covered container with a clean shovel and transport it to the waste disposal site. The floor can also be sprinkled with soda ash, and then washed with a large amount of water. The diluted washing water is put into the wastewater system. If there is a large amount of leakage, it shall be collected and recycled or discarded after harmless treatment.

Protective measures

Announce

edit

Respiratory protection: When the concentration in the air is high, you should wear a gas mask. Wear self-contained breathing apparatus during emergency rescue or escape.

Eye protection: wear chemical safety goggles.

Protective clothing: wear work clothes (made of anti-corrosion materials).

Hand protection: wear rubber gloves.

Others: After work, take a shower and change clothes. Pay attention to personal hygiene.

First aid measures

Announce

edit

Skin contact: Take off the contaminated clothes and wash with flowing water for 10 minutes or 2% sodium bicarbonate solution. In case of burns, seek medical treatment.

Eye contact: immediately lift the eyelids and flush with flowing water or normal saline for at least 15 minutes.

Inhalation: quickly leave the site to a place with fresh air. Keep the respiratory tract unobstructed. Perform artificial respiration when necessary. Get medical attention.

Ingestion: Rinse the mouth immediately and give milk or egg white to those who take it by mistake. Get medical attention.

Extinguishing method: fog water, foam, carbon dioxide, sand.^[3]