Acute phase reaction protein

protein

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Acute phase reaction APRP (acute phase reaction protein) is a kind of protein that causes inflammation, infection miocardial infarction and tumour Under such circumstances, the plasma concentration changes significantly protein 。 include α 1-Antitrypsin （α1-AT）、 α 1-acid glycoprotein （α1-AG）、 Haptoglobin （Hp）、 Ceruloplasmin （CER）、C4、 C3 Fibrinogen（ FIB ）, C-reaction Globulin （ CRP ）Wait. Its plasma concentration is in the range of inflammation trauma , myocardial infarction, infection, tumor, etc. There are three other proteins: Prealbumin 、 albumin and transferrin A corresponding low level appears. The above Proteoid They are collectively called acute phase reaction proteins, and this phenomenon can be called acute phase reaction. This is the body defense mechanism The detailed mechanism is not yet very clear. When the body is in the state of inflammation or injury Tissue necrosis And the increase of organizational updates, Plasma protein A series of characteristic changes have emerged, which are related to the Time course Relevant, which can be used to identify acute Subacute And chronic Pathological state 。 To some extent, it is also related to the nature and scope of pathological damage. For example, simple surgical trauma, C-reactive protein And α 1 Antichymotrypsin It rises within 6-8 hours. Then, α 1AG increased within 12 hours. AAT, Hp, C4 and Fibrinogen And finally C3 and CER increase, reaching the main peak within 2-5 days, accompanied by PA , Alb and TRF. If there is no concurrent infection immunoglobulin There can be no special changes, α 2MG can also be unchanged 。 Therefore, combining the last several items can be used to monitor whether patients are accompanied water loss and Blood volume Indicators of change.

Chinese name: Acute phase reaction protein
Foreign name: acute phase reactants,APR

Include: Antitrypsin, α 1-acid glycoprotein
Identification: Acute, subacute and chronic Pathological state

Substance Introduction

Its plasma concentration is higher in inflammation, trauma miocardial infarction , infection, tumor, etc. There are three other proteins: prealbumin, albumin and transferrin A corresponding low level appears. These proteins are collectively called acute phase reaction proteins, and this phenomenon can be called acute phase reaction. This is a part of the body's defense mechanism, and its detailed mechanism is not yet very clear.

When the body is in the state of inflammation or injury Tissue necrosis And the increase of organizational updates, Plasma protein A series of characteristic changes have emerged successively, which are related to the time course of inflammatory trauma and can be used to differentiate acute, subacute and chronic Pathological state 。 To some extent, it is also related to the nature and scope of pathological damage.

For example, simple surgical trauma, C-reactive protein And α 1 Antichymotrypsin It rises within 6-8 hours. Then, α 1AG increased within 12 hours. AAT, Hp, C4 and Fibrinogen Increase of, finally C3 And CER increase, reaching the main peak within 2-5 days, accompanied by PA , Alb and TRF. If there is no concurrent infection immunoglobulin There can be no special changes, α 2MG can also be unchanged 。 Therefore, combining the last several items can be used to monitor whether patients are accompanied water loss and Blood volume Indicators of change.

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