turnironProtein, also known as transferrin, TRF, siderophilin, is the main protein in plasmaFerritin, responsible for carrying byAlimentary canalAbsorbed iron andred blood cellIron released by degradation.Entered in the form of TRF-Fe3+complexbone marrowFor the generation of mature red blood cells.
The molecular weight of TRF is about 77000, which is a single chainglycoprotein，sugar contentAbout 6%.TRF reversibly binds multivalent ions, including iron, copper, zinc, cobalt, etc.Each molecule of TRF can bind two ferric atoms.TRF is mainly composed ofHepatocytesynthesis,half life7 days.The concentration of TRF in plasma is regulated by iron supply. In iron deficiency state, the concentration of TRF in plasma rises and returns to normal level after effective iron treatment.
transferrin
TRF levels in plasma can be used toanemiaDiagnosis and monitoring of treatment.In low iron deficiencyHemoglobinThe level of TRF in anemia is increased (due to its increased synthesis), but its ironsaturationVery low (normal value is 30% - 38%).Conversely, if anemia is caused byred blood cellBarriers to iron utilization (e.gAplastic anemia）, TRF in plasma is normal or low, but iron saturation is increased.When iron load is excessive, TRF level is normal, but saturation can exceed 50%, or even reach 90%.
Immune kit is available to supply antibody levelStandard。useImmunodiffusionorTurbidimetrytesting.Normal adultsreference value2200-4000mg/L.Newborn: 1300-2750mg/L.clinical evaluation Always measure at the same timeSerum ironContent and iron binding capacity (TIBC) of TRF, and calculated TRF iron saturation (%).TRF can also be indirectly calculated and estimated through measurement, and its calculation equation is as follows:
