Chagas disease，also known as American trypanosomiasis，is a potentially life-threatening illness caused by the protozoan parasiteTrypanosoma cruzi1个。
6 million people disease affects approximately6 million people1个，mainly in Latin America。在排水管道中的排水量1%2，and current available drugs have high rates of adverse effects and do not meet the need for the entire spectrum of the disease。Chagas disease usually begins with a bite by the triatomine bug，also known as the“kissing bug”because it usually bites people’s faces when they sleep。Often people are infected without even noticing it。
The disease sits at the crossroads between two worlds:it starts asa tropical parasitic disease but can end asa chronic disease。This is is why preventing，treating and managing Chagas disease requires an integrated，end-to-end approach that covers both the acute and chronic phases。
Improving health outcomes for Chagas patients also requires being active on three fronts:novel drug discovery，clinical development，and healthcare system strengthening。
TheNITD Novartis Institute for Tropical Diseasesand partners are discovering novel parasite-specific growth inhibitors for the treatment of Chagas disease and other kinetoplastid diseases。These efforts have identified unique drug targets in trypanosomatid parasitic protozoa that include proteosomes，CDC-like kinases，and topoisomerases。A drug candidate to address chronic Chagas disease is now in early-stage clinical trials。
During the chronic phase，when the disease evolves，it can affect key organs as the heart，leading to cardiac disorders in up to 30%of patients and up to 10%may develop neurological and/or gastrointestinal disorders。Chagas cardiomyopathy accounts for the majority of death and disability among individuals affected by the disease。Against this background，in2019，in collaboration with the Brazilian Clinical Research Institute，Novartis launched the first clinical study in people with heart failure due to chronic Chagas cardiomyopathy to assess an innovative therapy in this underserved patient population。This Phase IV trialso includes sub-studies that may help better understand the underlying pathophysiology of Chagas cardiomyopathy（biomarkers，arrhythmia burden，and use of magnetic resonance imaging to evaluate cardiac structure，function and fibrosis）。
Further，we are working with health authorities and stakeholders in Latin America on healthcare system strengthening initiatives to improve health outcomes and access to innovation。For example，Novartis signed a collaboration agreement with IS Global to improve the well-being of Chagas patients in Bolivia。Aiming for long-term sustainability，local empowerment and impact，the interventions are implemented in phases hand-in-hand with Bolivian and regional stakeholders。In2022，we were involved ina capability-building program，reaching more than200healthcare professionals。We are also collaborating with the Global Chagas Disease Coalition to develop an online medical platform for Chagas disease，which aims to build capability among healthcare professionals to adopt an integrated disease management approach。
We supported the World Heart Federation（WHF）and the Inter-American Society of Cardiology in developing anChagas disease for end-to-end roadmap，published in 2020。It explores the patient journey from diagnosis to treatment，and provides actionable recommendations for policymakers and healthcare professionals。In2022，under a research collaboration with the WHF and the Federal University of Minas Gerais in Brazil，we kicked off the RAISE study（The buRden of ChAgas dISEase in the contemporary world）to assess the health and economic burden of Chagas disease globally。
In2019，Novartis joined theGlobal Chagas Disease Coalition，an alliance to increase disease awareness and foster synergies in controlling the disease and promoting access to diagnosis and treatment。
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Read the photo story Chagas Disease:Bringing Chagas disease to people’s attention
Read the photo story Chagas Disease:Breaking the silence
