Alcohol dehydrogenase (ADH), also known as alcohol dehydrogenase, is a group of compounds, CAS No. 9031-72-5, which exists in the digestive system of human beings or other animals.
Alcohol is decomposed in the human body, and more than 90-95% of it is oxidized, and the dehydrogenation process is the most important stepAldehyde dehydrogenasebe responsible for.
The alcohol dehydrogenase system can reversibly catalyze the formation of alcohol dehydrogenationaldehyde(or ketone) enzyme involved in alcohol fermentation.EC1．1．1．1。CH3CH2OH+NAD=CH3CHO+NADH+H+。The substrate specificity is wide, and it also acts on other alcohols.In addition to yeast, it is also widely found in higher plants (especially when the activity increases during germination), animal livers, bacteria and other biological fields.Fromyeast(E.Negelein, H.J. Wulff 1937) orliverIs extracted in crystalline state.Obtained from yeastCrystalline moleculeIt is a SH enzyme with an amount of about 150000, composed of four subunits and bound with four NAD+and zinc.The molecular weight of liver enzymes is about 73 thousand.In mesenteryLeuconostoc(Leuconostomesenteroi des), yeast and higher plants have also found enzymes that use NADP+as coenzyme instead of NAD+(EC1.1.1.2, EC1.1.1.71).
Sorbitol dehydrogenase
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[Reference value] Ultraviolet method: serum: 0 ～ 2.6U/L for adults and 0 ～ 6U/L for children
[Clinical significance] The increase of serum SD activity is mainly seen in acute hepatitis, with a positive rate of about 87%. Most of the enzyme activity has increased in the early stage of hepatitis or before the emergence of jaundice, reaching a peak one week after the onset of disease, which is 6 times higher than the upper limit of the reference value. The increase is roughly parallel to that of transamination, and falls to the reference value within three weeks.
The serum SD activity in patients with chronic hepatitis and persistent hepatitis only occasionally increased.
The positive rate of serum SD activity increase in patients with cirrhosis was 42%, and the increase amplitude and average value were lower thanAcute hepatitis。
Congestive heart failureWhen the secondary damage of hepatocytes is caused by hypoxia, the enzyme activity can be significantly increased.
When obstructive jaundice has a short course and does not cause hepatocyte damage, the serum SD activity of the patient is generally not increased.
Endotoxin can increase the activity of SD in serum.
Pulmonary infarctionThe serum SD activity of the patients also increased significantly.
