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Zymogen

[méi yuán]
Enzymes are inactive precursors when synthesized in cells
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Zymogen refers to the function of converting zymogen into active enzyme, which is called Zymogen activation
Chinese name
Zymogen
Foreign name
zymogen
Definition
Enzymes are inactive precursors when synthesized in cells
Example
digestive enzyme Proenzyme of
Substance Introduction
Zymogen( zymogen
Some enzymes are only inactive precursors of enzymes when they are synthesized or released in cells. Under certain conditions, the precursors of these enzymes must be hydrolyzed to open one or several specific Peptide bond , resulting in conformation It changes and shows enzyme activity. The precursor of this inactive enzyme is called zymogen.
Some enzymes are only inactive precursors of enzymes when they are synthesized or initially secreted in cells. The precursor material is called zymogen, and the function of transforming zymogen into active enzyme is called Zymogen activation (zymogen activation)。
Zymogen
Well known examples are digestive enzyme Proenzyme of( Pepsinogen Trypsinogen Chymotrypsinogen )And blood Coagulase Proenzyme of( prothrombin Plasminogen )。 gastric acid It can activate pepsinogen. The zymogen can be stored in its synthetic site without causing the danger of self digestion (hydrolysis) of cells or tissues, and can be activated when cells need it· The reason why the zymogen is inactive is that active center Not formed or exposed. Generally, through Polypeptide chain The cutting modification of Active center of enzyme Formed or exposed.