It is synthesized in the pancreas and exists inPancreatic juiceSecreted into the duodenum, throughEnterokinaseRole of lysine at position 6 and position 7isoleucineCut off between.When the peptide chain (H-val-Asp4-Lys-OH) from the N-terminal to the 6th position is cut off, the activity will appear (such as cattle).This activation can also be carried out through the autocatalytic reaction of trypsin.