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Feedback inhibition refers toEnd productInhibition, that is, the inhibition caused by the end product of biosynthesis pathway to regulate the activity of enzymes in this pathway during the synthesis process.
Feedback inhibition andFeedback repressionThe difference is that feedback repression is the regulation of transcriptional level, which produces slow effect, while feedback inhibition is the regulation of enzyme activity level, which produces fast effect.In addition, the former often affects multiple enzymes that catalyze primary reactions, while the latter often only acts on the first enzyme in a series of reactions.
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Feedback inhibition in branching metabolism
Multivalent feedback suppression
Each single excess of multiple end products in the branch metabolic pathway does not inhibit an earlier enzyme in the common pathway, so it does not affect the entire metabolic progress. Only multiple end products are simultaneously excess will affect thekey enzymeIt has inhibitory effect.
Collaborative feedback suppression
Collaborative feedback suppressionAndMultivalent feedback suppressionThe same thing is that multiple end products should be excessive at the same time to inhibit key enzymes.The difference between the two is that when the single end product is excessive, the synergistic feedback inhibition will inhibit the first enzyme on the branch, but will not affect other metabolism.
Cumulative feedback suppression
Any excess of multiple end products can partially inhibit the key enzymes in the common pathway alone, but to achieve the maximum inhibitory effect, multiple end products must be excessive at the same time, and the feedback inhibition of each end product has a cumulative effect.
Synergistic feedback inhibition
When any end product is excessive, it only partially inhibits the activity of key enzymes in the common pathway. When several end products are excessive, it can cause strong inhibition, and the inhibition degree is greater than the total inhibition effect when each product is alone excessive.
sequential feedback inhibition
The end products indirectly inhibit the key enzymes of the common pathway by inhibiting the first enzyme on their respective branches when excessive, so that the former intermediate products accumulate.
