Nickel containing enzyme that catalyzes the hydrolysis of urea to produce ammonia and carbon dioxide. his active center contain amino formic acid root Bridging Binuclear nickel [2] 。 Nickel containing Oligomerase 。 Mr is about 483000. pI4.8， Optimum pH 7.4, with Absolute specificity Specifically catalyze urea hydrolysis to release ammonia and carbon dioxide. CO(NH2)2 + H2O →CO2 +2NH3 It can decompose urea (urea) into ammonia and carbon dioxide or Ammonium carbonate Of enzyme 。 It is widely distributed in the seeds of plants, but it is rich in soybean and concanavalin. It also exists in animal blood and urine. Some microorganisms can also secrete urease.
It is mainly used to determine urea in biological fluids (coupled with GLDH, in the ultraviolet method). · It can be used as an enzyme label, for example in ELISA ’s.) 
