meningitis

[nǎo mó yán]
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Acute or chronic inflammation of the meninges
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Meningitis refers to Pia mater Of Diffuse Inflammatory changes. from Bacteria Viruses fungus Spirochete protozoan Rickettsia tumour And leukemia And other biological properties Pathogenic factor Invasion of pia mater and spinal cord membrane. Bacterial meningitis It is a very serious disease that needs to be treated in time. If it is not treated in time, it may die or cause Permanent Of brain damage Viral meningitis Although it is serious, most people can fully recover, and a few remain sequela Meningitis may be involved Dura mater Arachnoid membrane And pia mater. Dural meningitis is often secondary to skull infection.
TCM disease name
meningitis
Foreign name
meningitis
Visiting department
Internal Medicine-Neurology
Common causes
Caused by infection of meninges or meninges
common symptom
Fever, headache vomit , loss of appetite, poor spirit, etc

type

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Since antibiotics were widely used, the incidence of dura meningitis has been greatly reduced. Soft meningitis is quite common, including arachnoid membrane and soft meningitis. Therefore, meningitis actually refers to soft meningitis. Meningitis is mostly caused by pathogens, and epidemic meningitis caused by meningococcal meningitis is the main type; A few are caused by irritant chemicals (such as procaine and methotrexate).
There are three basic types of meningitis: purulent meningitis, lymphocytic meningitis (mostly caused by viruses), and chronic meningitis (caused by tubercle bacillus, treponema pallidum, brucella and fungi).

pathogeny

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It is a kind of meningitis caused by various pyogenic bacteria, which is a major category of bacterial meningitis. It is one of the serious intracranial infections, often Suppurative encephalitis And brain abscess coexist. common pathogenic bacteria There are 3 types, namely Haemophilus influenzae Type B Neisseria meningitidis Diplococcus )And Streptococcus pneumoniae (Diplococcus pneumoniae). Usually, a small number of healthy people carry these germs in the nose or on the body surface without harming the human body cough Or sneeze. People are most vulnerable cold Is infected by germs, because rhinitis It makes it very easy for bacteria to enter the brain.
Is created by Mycobacterium tuberculosis Non suppurative inflammation of the meninges. About 6% of systemic tuberculosis is the most common central nervous system Tuberculosis is not only the most serious type of tuberculosis, but also a child tuberculosis The main cause of death. Mycobacterium tuberculosis After the infection spreads through blood Pia mater Lower planting formation Tuberculous nodule , large amount of nodules after collapse Tuberculosis bacteria get into Subarachnoid space in recent years, Tuberculous meningitis Incidence and mortality There is an upward trend. early diagnosis And treatment can improve curative effect and reduce mortality.
3. Viral meningitis
Multiple departments Viruses Infection of the central nervous system. The viruses that can cause meningitis are Arbovirus enterovirus Echo virus Poliovirus Coxsackie virus A and B, Echo virus Myxovirus and Paramyxovirus Herpes virus , sand virus, etc., followed by Mumps virus herpes simplex virus and adenovirus Viruses often invade brain parenchyma Meningoencephalitis Performance, Genus Aseptic meningitis
Meningitis can also be caused by fungi. The most common one is Cryptococcus , available at Pigeon droppings Found in. Cryptococcal meningitis is a deep disease caused by some species or varieties of Cryptococcus invading the central nervous system mycotic infection Healthy people are not susceptible to fungal meningitis, but for those HIV The infected people are different. Cryptococcal meningitis can occur after cryptococcus infection.

clinical manifestation

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Early manifestation: children mentality Change, such as irritability and crying; Mental dullness; Do not like games; There may be Low fever Anorexia Vomiting, restless sleep and emaciation.
Older children can complain headache If the condition is serious, the headache will continue and worsen, and the vomiting will worsen and become jet, gradually appearing Lethargy , convulsions may also occur, and coma, frequent convulsions, limbs Muscle relaxation , Paralysis. Irregular breathing may also occur, and some children may die.
It is common for children and the elderly pyogenic bacterium Meningitis caused by. The main symptoms are fever, headache, vomiting, irritability, etc. nervous system Inspection and Cerebrospinal fluid examination Exception. Because of children Resistance Weak, blood brain barrier The development is not perfect, and bacteria are easy to enter the brain nervous system. It is generally caused by infection in other parts of the body septicemia , caused by bacteria entering the brain. Partly due to tympanitis Head injury After infection, the bacteria enter the meninges directly.
Acute onset in childhood, high fever can reach above 39 ℃, and children often complain violently headache , poor spirit, fatigue, anorexia, frequent vomiting. At the onset of the disease, the child is conscious. The disease progress may lead to drowsiness, confusion, confusion of speech, inability to correctly identify directions, convulsions, and coma. In case of serious illness 24 hours There were convulsions and coma. If not treated in time, the disease progresses, stiff neck , the head is backward, the back is stiff, and the whole body bends back like a "bow", which is called in medicine opisthotonos Irregular breathing may also occur, even respiratory failure, and some children's skin may have Bleeding spot
Because the lesions can cause meningeal adhesions and brain parenchyma damage, cranial nerve paralysis, blindness Hearing impairment Limb paralysis epilepsy And mental retardation.

inspect

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(1) Hemogram The white blood cell count of peripheral blood in acute stage was significantly increased Neutrophils Mainly can occur, but not Mature cell
(2) Cerebrospinal fluid Pressure increases, appearance is turbid and purulent, white blood cell The count ranges from 1000 to 10000/mm, and is higher in a few cases, mainly neutrophils, which can account for more than 90% of the total number of white blood cells. Sometimes Purulent cell At this time, the smear and pathogen culture were mostly positive. Occasionally, the lumbar puncture was normal for the first time, and became purulent after re examination several hours later. The protein increases to more than 1.0g/L, and the sugar content decreases, usually below 2.2mmol/L, chloride The content also decreased, immunoglobulin IgM and IgG Significantly higher.
(3) Bacterial antigen determination Common methods include polymerase chain reaction Counter immunoelectrophoresis Latex agglutination test ELISA radioimmunoassay Etc.
(4) Other selective inspections Including: blood and urine routine, blood electrolyte, blood sugar, liver and kidney function.
(1) X-ray examination The chest radiograph of patients with purulent meningitis is particularly important, which can be found pneumonia Focus or abscess Brain and sinus plain film can be found Osteomyelitis of skull nasosinusitis Mastoiditis , but the above pathological changes CT examination More clearly.
(2) CT MRI examination Early CT or brain MRI examination can be normal. Having nervous system complication Visible when Ventricular enlargement Sulcus cerebri Narrow, brain swelling, brain displacement and other abnormal manifestations. And can find the ependyma Membranitis Subdural effusion And limitations brain abscess Enhanced MRI is more sensitive than enhanced CT in the diagnosis of meningitis. MRI scan can show meningeal exudation and Cortical response Take appropriate technical conditions , can display venous occlusion and infarct

diagnosis

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In addition to clinical manifestations and examinations. Meningitis should be diagnosed Waist wear Operation.

complication

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If the treatment is improper, the disease may change from acute to chronic, and the following sequelae may occur:
two Cranial nerve Damaged paralysis
3. Brain base Vasculitis Obstruction of lumen
Cause corresponding parts cerebral ischemia And infarction.

treatment

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Bacterial meningitis It is a life-threatening disease and should be treated immediately. When symptoms appear, you should go to the emergency room.
Bacterial meningitis The treatment is mainly based on cerebrospinal fluid smear And culture to find bacteria according to Drug sensitivity test Choose effective antibiotics and treat them in time to reduce the occurrence of sequelae. Still need to deal with the symptoms High fever , control convulsion, reduce intracranial pressure , mitigation Cerebral edema And use less hormone Intracranial inflammation Adhesion.
Antibiotics Viral meningitis It doesn't work, it should be added antiviral Drugs.

prevention

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1. Early detection and local isolation treatment.
2. Do a good job during popularity Health promotion Large gatherings and group activities should be avoided as far as possible. Children should not be brought to public places. They should wear masks when going out.
3. On Mesencephalon When popular fever companion headache Mental malaise Acute pharyngitis Skin Oral mucosa In case of two of the four items, such as bleeding, preventive treatment can be used to reduce the incidence and prevent the epidemic.