Scientific research institutions of the Chinese Academy of Medical Sciences
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Virus genetic engineeringkey state laboratories[1]Supported by the Science and Technology Bureau of the National Planning Commission in 1987Chinese Academy of Medical Sciences/Peking Union Medical CollegeThe Institute of Pathogenic Biology was established, passed the national acceptance in 1989 and officially opened for operation.The laboratory is mainly engaged inMolecular virologyandVirus genetic engineeringThe application of basic research.The laboratory follows the policy of open, joint and mobile offices.
Chinese name
State Key Laboratory of Virus Genetic Engineering (Institute of Virology, Chinese Academy of Preventive Medical Sciences)
Virus genetic engineeringkey state laboratories[1]rely onChinese Academy of Medical Sciences/Peking Union Medical CollegeThe Institute of Pathogenic Biology, whose laboratory was founded in 1987, adopted the policy of "building while opening", passed the acceptance inspection in 1989 and was officially opened for operation.In 1993 and 1996, it was rated as an excellent national key laboratory for two consecutive times, and in 2001, it was rated as good.The current laboratory director is researcher Jinqi;Director of Academic CommitteeHou YundeAcademician agent.
(6) Viral and its receptorMononucleotideDiversity and virus chips.
Project achievements
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Since the establishment of the laboratory, the laboratory has made numerous scientific research achievements:
First, ingenomeIn terms of engineering research, the largestAnimal virus——ChinaVaccinia virusTiantan strain and birdsadenovirus、enterovirusseventy-oneIsogenomeAfter the determination and analysis of the complete sequence, the pathogen causing dysentery, a common disease in China, was first completed internationally——Shigella flexneri 2a Genome sequencing and analysis, and many important discoveries;
Second, yesHepatitis C virusThe structure and function of the genome were systematically studied, and the molecular basis of HCV carcinogenesis was preliminarily clarified;
Third, it is the first to find and proveEscherichia coliEnhance sub sample sequence, and use this discovery to applyGenetically engineered drugsAnd successfully developed two new types of Escherichia coli with high efficiencyexpression vector And become the longest used genetic engineering laboratory in Chinabiological materialsone of;
Fourth, in terms of antiviral research, we have successfully developed a series of genetically engineered human interferon alpha products, becoming the first batch of high-tech products to be put on the market in China. Among them, interferon a1b is a class I new drug, which is the first in China and is used to treat common and frequently occurring diseases in China;stayAntiviral effect of traditional Chinese medicineIn terms of research, TCM was first discoveredAstragalus membranaceusThe synergistic effect of astragalus membranaceus and interferon on the antiviral effect was expounded.
The laboratory has won more than 40 awards at the provincial and ministerial level, including one first prize of the National Science and Technology Progress Award, seven second prizes of the National Science and Technology Progress Award, one second prize of the National Natural Science Award, one third prize of the National Invention Award, one fourth prize of the National Natural Science Award, and ten first prizes of the Sanitary Step Science and Technology Progress Award;9 new drug certificates were successively obtained;He has published more than 500 scientific research papers, more than 10 monographs, more than 50 patents and more than 100 doctoral students on famous academic journals at home and abroad, including Cell, Science, etc.About 150 people go abroad for further study from this laboratory.
Over the years, the laboratory has trained a number of outstanding young scientific and technological talents, including Jin Qi, Jin Dongyan, Wu Xiaobing, etc., who have now become leaders in scientific research.Researcher Jinqi served as the standing deputy director of the laboratory973 PlanChief scientist of the "Basic Research on the Prevention and Treatment of Serious Infectious Diseases" project, leader of the 863 Program Bioinformatics Expert Group and other key positions;WonNational Natural Science Award, the National Invention Award, the U.S. "Human Health and Service Department Secretary Award", James H. Nakano Outstanding Scientific and Technological Paper Award and other awards, and wonNational Science Fund for Distinguished Young ScholarsAnd the national title of "Young and middle-aged experts with outstanding contributions".
Over the years, the research achievements of the laboratory have had a great impact at home and abroad, and have been highly praised by peers at home and abroad.In December 1995, Science's column "Science in China" introduced our laboratory;Over the years, more than 200 laboratories in China have used the biomaterials developed by the laboratory;Since 1989, half of the new gene drugs approved for marketing in China have used the research results of our laboratory, andNorth China PharmaceuticalShenzhen Kexing and other well-known domestic pharmaceutical enterprises have established achievement transformation bases, thus making important contributions to the development of China's high-tech biotechnology industry.
Recent Overview
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In 2011, biological science and medical sciencekey state laboratoriesThe evaluation results were released, and the State Key Laboratory of Virus Genetic Engineering was a poor laboratory.The inferior national key laboratories will no longer be listed in the national key laboratory sequence.
