Generally, growth hormone is human growth hormone for injection[5]Abbreviation of (former name:Recombinant human growth hormone for injection[2]), produced by gene recombination technologyamino acidContent, sequence andprotein structureIt is completely consistent with human pituitary growth hormone.staypediatricsField, using growth hormoneAlternative treatment, can significantly promote the growth of children's height.At the same time, growth hormone in the reproductive fieldburnIt also plays an important role in the field of anti-aging.It has been widely used in clinic.[1][3-4]
(1) Pre filling packaging: single tube single dose packaging, without adding preservatives, can be directly injected in one step, without dispensing and needle replacement.
(2) Cartridge packaging: single tube multi dose packaging, single tube multi dose packaging, adding preservatives (mostly phenol), repeated injections, need to use a syringe to extract liquid medicine for injection.[1]
component
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1. Human growth hormone for injection:
The main components are human growth hormone and forming agent.
1. The following may occur when using growth hormoneAdverse reactionsThe information comes from abroadSimilar productsLiterature data, including those occurring in clinical trials and after marketingspontaneityAdverse reactions reported in the report.
2. Data from clinical trials of growth hormone products abroad: because clinical trials are conducted under different conditions, adverse reactions of a growth hormone preparationincidence rateIt is often not comparable with another growth hormone preparation, and the incidence of adverse reactions cannot reflect the actual clinical use.
3. Growth hormone is a protein drug, and a few patients will produce antibodies after use.Some studies have shown that a few patients who have not used growth hormone therapy produce growth hormone 6 months after using growth hormone therapySpecificityAntibody, but the antibody concentration does not exceed 2mg/L.Long term injectionRecombinant human growth hormoneIf antibody is produced, but antibodyBinding forceLow, no definite clinical significance.However, if the antibody binding force exceeds 2mg/L, the efficacy may be affected.Any patient who does not respond to growth hormone treatment, in addition to evaluating theirComplianceAnd thyroid function should be treated with growth hormoneAntibody test。[1]
taboo
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1、epiphysisIt is forbidden to be used for growth promotion treatment after it has been completely closed.
3. Known effects on growth hormone or itsProtective agentIt is forbidden for people with allergies.
4. Disabled in presence of activityMalignant tumorPatients.Any existing malignancytumourIt should be inactive, and tumor treatment should be completed before growth hormone treatment.Growth hormone therapy should be stopped if there is evidence that there is a risk of tumor recurrence.Because growth hormone deficiency may bePituitary adenoma(or other rarebrain tumor)Early stage of existencesignTherefore, the existence of such tumors should be excluded before treatment.Growth hormone should not be used for any potentialIntracranial tumorProgressive or recurrent patients.
5. Occurrence of the following acute critical diseasescomplicationWhen prohibited: open heart surgery, abdominal surgery or multiple accidental injuries.
3. Simultaneous useCorticosteroidsIt will inhibit the growth promoting effect of growth hormone, soACTHThe dosage of corticosteroids should be properly adjusted in patients with deficiency to avoid the effect of growth hormoneinhibition。(SeeDrug interaction)
4. A few patients were treated with growth hormonePossibleHypothyroidismIt should be corrected in time to avoid affecting the efficacy of growth hormone. Therefore, the patient should have regular thyroid function examination, and if necessarythyroxineSupplement to.
5. Endocrine disorders (includingGrowth hormone deficiency)Of patients may haveFemoral headEpiphyseal plateSlippage, if claudication occurs during the treatment period of growth hormone, attention should be paid to evaluation.
6. Sometimes growth hormone can cause excessiveinsulinStatus, so we must pay attention to whether the patient hasGlucose toleranceThe phenomenon of reduction.
7. If the blood sugar is higher than 10mmol/L during treatment, insulin treatment is required.If you need more than 150IU/day insulin, you still can'tEffective controlBlood sugar, this product should be stopped.
8. Growth hormone takingsubcutaneous injectionYou can select around the navel, the upper arm, the outside of the thigh, and the buttocks.The injection of growth hormone requires frequent site changes to prevent long-term injection at the same siteSubcutaneous fat atrophy。If the injection is conducted at the same site, the interval between injection sites shall be more than 2cm.
Drugs for pregnant and lactating women
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Not suitable for use.
Children's medication
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Children's understanding of growth hormone in pharmacology, toxicologyPharmacokineticsThere is no significant difference with adults in terms of weight. It can be used safely according to weight.
2. Simultaneous use of non androgenssteroidIt can further increase the growth rate.
Storage method
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1. Human growth hormone for injection:
It can be stored and transported in a dark place at 2~8 ℃ for 7 days at room temperature, and the dissolved solution can be stored in a refrigerator at 2~8 ℃ for 72 hours.
2. Human growth hormone injection:
Store and transport at 2-8 ℃ away from light and avoid freezing.[1]
term of validity
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1. Human growth hormone for injection:
24 months
2. Human growth hormone injection:
18 months[1]
Executive standards
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1. Human growth hormone for injection:
Chinese Pharmacopoeia 2020, registration standard: YBS00032020