State Key Laboratory of Biochemical Engineering (Institute of Process Engineering, Chinese Academy of Sciences)

Subordinates of the Chinese Academy of Sciences

Biochemical Engineering Countries^[1] Key laboratory support Chinese Academy of Sciences Process Engineering graduate school. Biochemical engineering (Biochemical Engineering), a cross discipline of biology, chemistry and engineering, rose in the 1980s, involving the theoretical and application basis of large-scale preparation of biological products. In 1988, with the joint proposal and support of Chinese biologists and chemical engineers, the State Planning Commission approved the Institute of Process Engineering (formerly the Institute of Chemical Metallurgy) of the Chinese Academy of Sciences to use World Bank loan Prepare to establish the State Key Laboratory of Biochemical Engineering. In 1995, the laboratory was completed and passed the acceptance organized by the National Planning Commission. In 2001, it passed the evaluation organized by the Ministry of Science and Technology and the National Natural Science Foundation of China. The laboratory director is Su Zhiguo Academician Yang Shengli is a researcher and the director of the Academic Committee.

Chinese name: State Key Laboratory of Biochemical Engineering
Establishment time: 1988

organizational management: Institute of Process Engineering, Chinese Academy of Sciences
Administrative subordination: Chinese Academy of Sciences

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research field

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The academic direction of the laboratory is to study the amplification theory and technology of biological culture and biological separation process, and realize the optimization of biological preparation process. The main research content involves the metabolic regulation of the large-scale cultivation process of animal, plant and microbial cells, focusing on the new airlift process with the characteristics of energy saving and good sealing performance, and the solid biological reaction process with the characteristics of water saving and cheap cultivation materials, and exploring the application of mass transfer theory, periodic oscillation theory and metabolic regulation theory; In terms of biological separation and purification, in view of the characteristics of high purity requirements of biotechnology products and easy inactivation of products, the technology of protecting protein activity in the process of separation and purification was studied and carried out protein folding Refolding, adsorption and separation of proteins, adsorption and separation of natural products, chemical modification of proteins, controlled release carriers of biological drugs, preparation of biological separation media, etc.

Project achievements

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Since 1996, it has assumed the responsibility of 863 Program 、 National Science and Technology Research Program 、 National Natural Science Foundation of China More than 100 international cooperation and provincial (large) key projects as well as various horizontal cooperation projects. Developed successfully on a large scale Animal cell culture reactor , semi submerged plant tissue culture reactor, large airlift double loop reactor, periodic oscillating loop reactor and other new types Bioreactor ； A series of new efficient penicillin extraction demulsifiers were developed; A new process of polymer concomitant biochemical separation was proposed, which greatly improved the yield and purity of protein; Preparation by new technology of segmented multiple crystallization hydroxyapatite ； The new technology and equipment of fluidization molding and drying and the technology of preparing microcarrier by aqueous two-phase method were invented. It has won one second prize of the National Science and Technology Progress Award, two first prizes, one second prize and six third prizes of the Chinese Academy of Sciences Science and Technology Progress Award; More than 600 papers have been published, including nearly 200 international academic journals and more than 160 SCI indexes; 4 academic monographs; 73 invention patents have been applied and 21 have been approved; More than 60 technology applications were promoted.

Academic team

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The eighth batch of students and teachers of the "Flying Plan"

The laboratory has built a young and high-level research team, including Su Zhiguo, Liu Huizhou and Ma Guanghui National Science Fund for Distinguished Young Scholars Su Zhiguo and Ma Guanghui entered the "Hundred Talents Program" of the Chinese Academy of Sciences. 90% of the academic team are graduate students, and 60% of them have obtained doctoral degrees. Since 1996, 20 young cadres have been sent abroad for study, further education and cooperative research through various channels. Among the more than 100 national level projects and provincial and ministerial key projects undertaken by the laboratory, 80% of young people under 45 years old are project leaders or substantive leaders. In terms of postgraduate training, there are doctor's and master's programs in biochemistry, 42 doctoral students and 75 master's students have been trained; More than 80% of them have won the Dean's Scholarship, the Director's Scholarship and the "Elita" Scholarship of the Chinese Academy of Sciences. The discipline also has Postdoctoral mobile station 10 postdoctoral researchers have left the station and become the backbone of biochemical engineering research and development in this laboratory and other units at home and abroad. The laboratory sets up an open fund and adopts the procedures of public application and academic committee review. Scholars at home and abroad are welcome to apply. Since 1996, our laboratory has approved more than 20 open fund projects, and the projects undertaken by domestic and foreign units account for more than 60%, with an average of 50000 yuan for each project. Some open projects have been transformed into national research projects, while others have promoted the cooperation between upstream and downstream units of biotechnology and achieved excellent results. The laboratory takes care of the living and scientific research conditions of the guest researchers, adopts a series of economic subsidy policies superior to the fixed personnel, and gives the guest researchers living subsidies according to the standards formulated by the laboratory.

Instrument and equipment

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The laboratory has many large-scale instruments, including multi-purpose automatic high pressure liquid chromatography Large capacity refrigerated centrifuge , ultrahigh speed centrifuge, protein and monoclonal antibody purification pilot chromatography system, glucose and lactic acid biochemical analyzer, diode matrix ultraviolet spectrophotometer, capillary electrophoresis system, continuous membrane filtration system, chromatography workstation, evaporative light detector, laser scatterer. HP chromatography Finnigen multi-level Mass spectrometer It is the most advanced GC-MS equipment at home and abroad, serving the whole country. It has successfully measured the molecular weight of proteins, nucleic acids, natural products and organic compounds for many units. The laboratory has the ability to develop various fermentation tanks and separation and purification equipment by itself, and has developed and provided many animal and plant, microbial cell culture reactors, separation and purification media and equipment to domestic units. Work closely with the laboratory National Research Center for Biochemical Engineering Technology (Beijing) has a pilot scale laboratory of 500 liter fermentation and extraction.

Strengthen original innovation, closely cooperate with the development of biotechnology in China, and cooperate with other biotechnology laboratories to develop a platform for large-scale preparation of biological products, especially Biopharmaceuticals and natural product Preparation technology platform renewable resource Utilize technology platform, biological decontamination and biological dosage form preparation technology platform, etc.

geographical position

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Institute of Process Engineering, Chinese Academy of Sciences (Zhongguancun North 2nd Street)

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