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dextran

Polymer of glucose
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Dextran is glucose The chemical formula is (C six H ten O five ) x, Often used as Antithrombotic drugs
Chinese name
dextran [1]
Foreign name
dextran [1-2]
chemical formula
(C six H ten O five ) x
CAS login number
9004-54-0 [1]
EINECS login number
232-677-5 [1]
Appearance
White or off white amorphous powder
Solubility
Easily soluble in hot water, insoluble in ethanol
Classification
High molecular dextran, medium molecular dextran, low molecular dextran, small molecular dextran

brief introduction

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Dextran yes sucrose through Leuconostoc mesenteroides -1226, a kind of polymer generated after fermentation glucose The polymer is processed and refined. Because the number of polymerized glucose molecules is different, products with different molecular weights are produced. yes High molecular dextran Average molecular weight 100000 to 200000) Medium molecular dextran (average molecular weight of 60000 to 80000) Low molecular dextran (average molecular weight of 20000 to 40000) Small molecule dextran (The average molecular weight is 10000-20000). Dextran 40 Dextran 70 It has been collected in rural and pastoral areas cooperative medical service Essential Drug List

character

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It is white or almost white amorphous powder, odorless and tasteless. Soluble in hot water, insoluble in ethanol Its aqueous solution is colorless or microstrip Opalescence Clear liquid of.

purpose

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by Blood volume expansion medicine , improved Plasma colloid osmotic pressure Increase plasma volume and maintain blood pressure, which can prevent red blood cell and platelet aggregation , reduce blood Viscosity To improve microcirculation Role of.
The product is mainly excreted from the body through the kidney, and its excretion rate is related to the molecular weight. After one hour of human body Small molecule dextran About 30%, 50% and 70% are discharged from urine respectively, 24 hours After that, about 60%, 70% and 80% were discharged respectively.

Usage and dosage

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Intravenous drip: 250-500mL each time, or depending on the condition.

Side effects and toxicity

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Occasionally Anaphylactic reaction as Urticaria skin Itch fever , nausea, vomiting, wheezing Arthralgia , bleeding, and very few of them have blood pressure drop dyspnea and Chest tightness Anaphylactic shock Rare.

be careful

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1、 Congestive heart failure , serious Thrombocytopenia Coagulation disorder Hemorrhagic disease Waiting for patients contraindicated Heart, liver Renal insufficiency Active pulmonary tuberculosis Allergic history And patients should use it with caution.
2. The speed of injection depends on the condition, such as for Hypovolemic shock , infusion should be fast, and pressurized infusion should be carried out when necessary. Inject 20-40mL of medium molecular weight preparations every minute, and 5-15mL of low and small molecular weight preparations every minute. When the blood pressure rises, the invasion can be reduced as appropriate. Small molecular weight preparations can be used for arterial infusion when necessary.
3. When it is used for the first time, the injection speed should be slow and closely observed for 5-10 minutes. It should not be mixed with whole blood transfusion to avoid Hemagglutination And aggregation. by Blood volume expander Can't replace The effect of whole blood. Pay attention to regulation during infusion electrolyte Balance of.
4. Small molecular weight preparations have diuretic effect, which is beneficial to prevent post shock Acute renal failure , but should not be used for serious nephropathy patient.
5. The dosage should not exceed 1500mL each time. If the dosage is too large, it may cause Bleeding tendency and Hypoalbuminemia Patients with excessive bleeding on the operating surface Acute inflammation Of Vasculitis Patients should not use too much or low or small molecular weight preparations to avoid increasing blood seepage or expanding inflammation.
6. Infusion of this product can accelerate ESR.

Storage

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Seal and store in a dry place.

preparation

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Medium molecular dextran (Dextran70):6% Dextran and sodium chloride injection (or 10% dextran sodium chloride injection), 250mL, 500ml per bottle;; 6% Dextran glucose injection 250mL and 500mL for each bottle.
Low molecular dextran (Dextran 40): 6% low molecular weight dextran sodium chloride injection (or 10% low molecular weight dextran sodium chloride injection, also known as Tongmai liquid), 100mL, 250mL, 500mL per bottle; 6% dextran glucose injection (or 10% dextran glucose injection), 100mL, 250mL, 500mL per bottle.
3. Dextran 10: 10% Small molecule dextran glucose injection 250mL and 500mL for each bottle.