附件,附件 :Atherosclerosis causes most heart attacks,strokes and peripheral arterial disease and remains the single leading cause of morbidity and premature mortality.Our portfolio and pipeline focus on therapies to reduce low-density lipoprotein(LDL)cholesterol and decrease inflammation, key drivers of the formation of playques in the arteries.Strategies to reverse atherosclerosis are also under exploration。 Heart failure :Heart failure with preserved ejection fraction is an increasingly prevalent disorder in which the pumping chamber becomes stiff and unable to function normally。 We seek to understand the mechanism driving this form of heart failure and develop novel therapies.We continue to develop next generation therapies to treat or prevent heart failure with reduced ejection fraction。 Atrial fibrillation :We seek to develop safer antiarrhythmic drugs to maintain normal sinus rhythm and to understand the root cause of atrial fibrillation to ultimately prevent it。 Obesity-Driven disease :Obesity is epidemic and drives type-2diabetes, cardiovascular risk,and a host of other diseases.We seek therapies that can deliver substantial and durable weight loss to reverse and prevent obesity-driven diseases。