Dry Eye Disease（DED）is a lack of quality lubrication that can lead to an inflammatory cycle of the ocular surface。1,2

Dry Eye Disease:a lack of quality lubrication can lead to an inflammatory cycle of the ocular surface
多平面显示器2,3
  • Involves a range of ocular structures:
    • Ocular surface（cornea，conjunctiva，accessory lacrimal glands）
    • 电子束，电子束
    • Innervation between the ocular surface and meibomian glands
Epidemiology
  • 预应力钢筋混凝土5-50%4个
  • Risk factors include age，gender，nutrition，genetic background，disease history and high use of digital screens3,4
  • 安nual cost to US health system is estimated to be US$3.84 billion4个
Symptoms and disease burden3
  • 试验性能
  • Ocular discomfort including redness，burning，and stinging
  • Visual disturbance
  • Potential damage to the ocular surface
  • 按需付费
不可计量的needs
  • Over-the-counter eye drops，the standard of care for DED，often have limited success in moderate-to-severe DED3,5
  • 人工DED生产短距离生产，delayed onset of action and poor patient tolerability6个
  • 手动调节阀门的导通阀，symptoms，and underlying pathogenic mechanisms of DED7

参考，参考

  1. Baudouin C，et al.Br J Ophthalmol.2016；100:30306；
  2. Craig JP，et al.Ocul Surf.2017；15（3）：276-283；
  3. Messmer EM.Dtsch Arztebl Int.2015；112（5）：71-82；
  4. Stapleton F，et al.Ocul Surf.2017；15（3）：334-365；
  5. Kim M，et al.BMJ Open Ophthalmol.2021；6:e000697；
  6. Shen Lee B，et al.Clin Ophthalmol.2020；14:119-126；
  7. Aragona P，et al.Br J Ophthalmol.2021；105（4）：446-453。

附加资源

Dry Eye Disease（DED）Development，symptoms，and triggers（PDF，21MB）

干Eye:Misunderstanding a Potentially Debiliting Disease-Eyetube

（车辆的）转向节和转向节

Dry Eye Disease:The Patients’Perspective-Eyetube