Pictured:Novartis'logo outside its building in San Diego，California/iStockJHVEPhoto
Novartison Tuesdayexpanded its peptide discovery collaboration宽度比，宽度比PeptiDreamin a deal worth more than$2.7 billion in milestone payments，making it the latest move in the red hot radiopharma sector。
Under the agreement，PeptiDream use its technology–the Peptide Discovery Platform System—to find new macrocyclic peptides against targets that Novartis has selected。These targets can be conjugated into radioligand therapies（RLTs），which may have other therapeutic or diagnostic uses。
Novartis is paying PeptiDream$180million upfront and is also eligible to receive$2.71billion in milestone payments。The biotech may also net tiered royalties on any product sales。
PeptiDream’sstock pricejumped24%on the news in Tuesday trading。
Novartis and PeptiDream have been working together on various deals since2010。In，In2019，the two companies agreed to find new peptide-drug conjugates。The terms of that partnership were not disclosed。
“We are delighted to further expand our long-standing macrocyclic peptide discovery collaboration with Novartis，adding additional peptide RLT and other programs to our strong partnership，”PeptiDream CEO Patrick id Resaid in a statement。“As macrocyclic peptides continue to be the ideal vectors for the targeted deliver of a variety of therapeutic payloads，PeptiDream continues to build an extensive pipeline of partnered as well as internal peptide-conjugate programs.”
PeptiDream has also been active in the deal space as the biotech received$40 million upfrontfrom Roche’s Genentech last year to discover radioisotope drug conjugates。The agreement is also worth up to$1billion in milestones。预应力混凝土路面Eli Lillyand，and电枢，电枢，among others。
“Our expanded partnership reflects our shared commitment to pioneering science that broadens the scope of transformative therapeutic approaches such as RLT，”Shiva Malek，global head of oncology research at Novartis，said in a statement。
Radiopharmaceuticals have been a big investment area for Novartis。In2018，the pharma spent over$6billion to acquire two companies，高级Accelerator Application S.A。and，andEndocyte.Out of those deals，Novartis gained access to the prostate cancer treatment Pluvicto and Lutathera。These radioligands have been good earners for Novartis，as Pluvicto raked in$310 million in thefirst quarter of 2024while Lutathera brought in$169 million。
在空中停车场，停车场，停车场，停车场，停车场AstraZenecainked a potential$2.4 billion deal in March2024 to acquire Fusion Pharmaceuticals，gaining access to its radio-conjugate candidate FPI-2265，a treatment for prostate cancer。Last year，Bristol Myers Squibbspent$4.1 billionto purchase RayzeBio，securing access to its lead radiopharma program。
Tyler Patchen is a staff writer atBioSpace.You can reach him attyler.patchen@biospace.com.Follow him onLinkedIn。
