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Glycopeptide bond

Glycopeptide linkage of protein
glycoprotein The oligosaccharide chain of is connected to the protein ser or Thr residue through the O-glycoside bond (glycopeptide bond) at the reducing end, or to the protein Asn residue through the N-glycoside bond (glycopeptide bond). The oligosaccharide chains in glycoproteins can be divided into N-linked oligosaccharide chains and O-linked oligosaccharide chains according to the types of glycosidic bonds. These two oligosaccharide chains can exist alone or simultaneously in the same protein. [1]
Chinese name
Glycopeptide bond
Alias
Glycopeptide linkage of protein
Type
Biological noun
Main types
Glycopeptide linkage of protein is called glycopeptide bond for short. The types of glycopeptide chains can be summarized as follows:
① N-glycoside bond type: oligosaccharide chain (GlcNAC β - Hydroxyl group) is connected with the amide group of Asn, the a-amino group of the N-terminal, the W-amino group of Lys or Arg
② O-glycoside bond type: oligosaccharide chain (GalNAC α - Hydroxy) and Ser serine, Thr threonine, tyrosine and hydroxylysine hydroxyproline The hydroxyl group of is connected.
③ S-glycoside bond type: glycopeptide bond with cysteine as the junction point.
④ Ester glycoside bond type: take the free carboxyl group of aspartic acid and glutamic acid as the connection point.