Citrate (Si) synthase
The system name is: acetyl CoA: oxaloacetate C-acetyltransfer [thioester hydrogenation, (pro-S) - carboxymethyl forming], EC2.3.3.1 (formerly EC4.1.3.7).
- Chinese name
- Citrate Synthase
- Foreign name
- citrate (Si)-synthase
Citrate Synthase Catalysis from Glycolysis Or other dissimilatory reaction Acetyl CoA And Oxaloacetic acid Condensation synthesis citric acid Reactive enzyme. Because the dissociation of CoA from acetyl CoA is Exothermic reaction （ Δ G0 '=- 7.7 kcal), so that the balance tends to generate citric acid. This enzyme controls Tricarboxylic acid cycle The entrance of is subject to various controls. It is Allosteric enzyme , subject to NADH ATP and α- Ketoglutaric acid Allosteric inhibition ， Succinyl coenzyme A And Acetyl CoA Competition inhibition, AMP can resist the inhibition of ATP Activation 。 It is circulating as tricarboxylic acid in liver and other tissues Speed limit steps , exists in Mitochondrial matrix (mit ochondrial matrix). 
