Genes derived from organisms other than those concerned or studied
Exogenous genes refer to genes that come from outside the organism concerned or studied. The process of introducing foreign genes into organisms is called transformation. This can occur naturally or artificially.
- Chinese name
- foreign gene
- Definition
- Genes derived from organisms other than those concerned or studied
Artificial transformation and transfection methods include: (a) chemical methods, including Calcium phosphate precipitation method DEAE glucan complexation and lipid mediated DNA transformation; (b) Physical methods, including electroporation, microinjection and particle bombardment; (c) Recombination methods, such as using viruses as vectors. Gene transformation of bacteria, plants and animals has important research and commercial value. Targeted exogenous gene introduction can identify the function of the original endogenous gene, because the imported exogenous gene can lead to the mutation or expression change of the inserted endogenous gene. This mutation technique is called insertional mutagenesis and is usually used Retrovirus As a carrier of DNA delivery. Such insertional mutations are often used to identify oncogenes at specific locations in tumor cells. Transgenic disciplines have been created by using exogenous gene transformation Recombinant DNA technology It can introduce new features that were not previously available to the organism. There are many organisms created through transgene, from bacteria to mammals, including sheep and monkeys, which have many uses: they are used to study developmental genetics, disease process and gene regulation. Transgenic animal It can produce drugs and increase the production of milk or meat. The tissues and organs from transgenic animals can be used for blood transfusion and transplantation, thus reducing the probability of immune rejection. 
