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Acetyltransferase, cell division S phase, the 56th lysine (H3-K56) on histone H3 is acetylated.H3-K56 has a significant acetylation effect, and failure will cause cells to be very sensitive to the conditions that cause DNA damage.Despite this, scientists have never foundHistone acetyltransferase(histone acetyltransfer, HAT) catalyzes the acetylation of spherical H3-K56.
Chinese name
Acetyltransferase
Foreign name
histone acetyltransferase
Discoverer
University of California River and New York University School of Medicine
Publish periodicals
Science
analysis
Zhiguo Zhang, Junhong Han and others from the Department of Biochemistry and Molecular Biology of Mayo Clinical Medical College and the University of California Riverside BranchNew York University School of MedicineThe cooperation of researchers found that the protein product 109 (Rtt109) of Ty1 transposition gene is a specialHistone acetyltransferase。The article was published in Science on February 2.
Lack of conservative Rtt109 or rtt109AspartateMutation of residues results in loss of H3-K56 acetylation ability of cells, increased sensitivity to genotoxic agents, and increased probability of spontaneous chromosome breakage.Therefore, researchers believe that although Rtt109 has no homology with any other known acetyltransferase, it is a specific acetyltransferase that acetylates H3-K56.
