News from our newspaper (apprentice reporter Jiang Qingling): Gan Yong, a researcher of Shanghai Institute of Materia Medica, Chinese Academy of Sciences, and Shi Xinghua, a researcher of National Nanoscience Center, have designed and synthesized a variety of drug carriers with different shapes, and have carried out detailed characterization through transmission electron microscopy and other technologies, It provides a new idea for the design of efficient drug delivery carriers to cross the complex barrier in vivo. On May 21, relevant research was published in the Journal of the National Academy of Sciences.
Drug carrier plays an important role in improving the safety and effectiveness of drugs. However, before reaching the target, the carrier needs to "cross mountains" and break through multiple obstacles, and the drug finally reaches the target tissue is less than 0.7%. Recent studies have shown that the physical properties of the carrier are the key factors determining its interaction with the biological barrier.
The research team found that the sharp spindle shaped nanocarrier (ENP5) showed better exosmosis and endocytosis in the high interstitial pressure environment in vivo and in vitro. On this basis, the researchers evaluated the anti-tumor efficacy of different shaped carriers loaded with the chemotherapy drug Dox in the mouse model, and found that Dox@ENP5 The inhibition of tumor was significantly enhanced.
The research team further found through experiments that in the process of vascular exosmosis, the high curvature of the carrier helps to reduce the fluid resistance and accelerate the migration speed of the shuttle carrier; In the process of tissue endocytosis, high curvature increases the jumping frequency of the carrier in the high pressure and dense extracellular matrix by promoting the rotation of the carrier, effectively accelerating the penetration of the carrier into the deep tumor, and significantly improving the drug delivery efficiency.
Relevant paper information:
https://doi.org/10.1073/pnas.2319880121
