Research sketch map provided by West Lake University On May 30, the team of Zheng Jusheng, a distinguished researcher of West Lake University, together with the team of Chen Yuming, a professor of Sun Yat sen University, and the team of Zhou Hongwei, a professor of Southern Medical University, titled "Intestinal flora bile acid axis connects the positive relationship between chronic insomnia and cardiovascular metabolic diseases", and relevant research results were published online in Nature Communication.
This study revealed for the first time that the intestinal microbiota bile acid axis may mediate the adverse effects of chronic insomnia on cardiovascular metabolic diseases, identified the main bacteria and bile acids that mediate the positive correlation between chronic insomnia and cardiovascular metabolic diseases, and found that long-term tea drinking habits can help alleviate the imbalance of intestinal flora and bile acid metabolism caused by chronic insomnia.
Zheng Jusheng's team cooperated with several domestic teams, taking Guangzhou Nutrition and Health Study (GNHS) as the discovery queue, and the Guangdong Gut Microbiome Project, GGMP) as a validation cohort, using multi-point follow-up data (6.2 years on average) and high-throughput multigroup data, we found the changes of intestinal microbiome and bile acid metabolites caused by long-term chronic insomnia, and revealed the key mediating role of intestinal microbiome and bile acid in the relationship between chronic insomnia and cardiovascular metabolic diseases.
The GNHS cohort is a Guangzhou cohort of middle-aged and elderly people (45~75 years old) with more than 4000 participants. Since the baseline recruitment from 2008 to 2013, all participants have been followed up every three years. The GGMP queue is a large crowd (18-97 years old) with more than 10000 participants from 14 different regions in Guangdong Province.
This study found the intestinal microbiome and bile acid markers affected by chronic insomnia, and for the first time suggested that chronic insomnia could increase the risk of metabolic diseases by affecting the intestinal microbiome bile acid axis. Six years of long-term dietary follow-up information shows that long-term tea drinking habits can help alleviate the intestinal flora and bile acid metabolism disorder caused by chronic insomnia. The above findings provide new coping strategies and potential intervention targets for preventing or treating the adverse effects of chronic insomnia on metabolic health.
It is reported that Jiang Zengliang, an assistant researcher of West Lake University, Zhuo Laibao, a doctoral student of Sun Yat sen University, and He Yan, a professor of Southern Medical University are the co first authors of the paper, and Zheng Jusheng, Chen Yuming, and Zhou Hongwei are the co corresponding authors of the paper.
Related paper information: https://doi.org/10.1038/s41467-022-30712-x
Author: Wen Caifei Source: China Science Daily
