Author: Xu Lingling
Associate Chief Physician | Peking Union Medical College Hospital Endocrine Department
two Type 2 diabetes, also known as non insulin dependent diabetes, as its name suggests, can be treated without insulin injection, but in some cases it should be treated with insulin instead. Many patients have concerns about insulin treatment, and fear that once it is used Becomes “ Dependent ” Well, whether it is dependent or not is due to the different pathogenesis, which has nothing to do with the use of insulin. Insulin is a hormone secreted by the human body under normal conditions, so it has no side effects such as damage to liver and kidney functions, and is a very safe hypoglycemic drug.
two The conversion of type 2 diabetic patients to insulin therapy is mainly seen in the following situations:
one When oral hypoglycemic drugs cannot effectively control blood sugar. The prerequisite for oral hypoglycemic drugs to control blood sugar is a certain amount of insulin secretion in the body. There are research findings, 50% Of two Type 2 diabetes fifteen More than years ago, due to the significant decline in islet function, insulin will eventually be selected to effectively control blood sugar. because two At the beginning of type 2 diabetes, many patients had no obvious symptoms and waited for many years to be diagnosed with diabetes. Therefore, many people had to switch to insulin only a few years after the diagnosis of diabetes.
two There have been serious complications. At this time, using insulin can better control blood sugar. As we know, one of the main reasons for diabetic complications is the poor control of blood sugar for a long time. Insulin is the most physiological drug, which can reduce blood sugar in a short time. In addition, a large number of studies have also shown that insulin itself can delay the progress of vascular complications.
three Patients with liver and kidney diseases. No matter which oral hypoglycemic drugs are more or less metabolized by the liver and kidney, they can be discharged from the body. If the liver and kidney functions are not good, the drugs taken cannot be discharged from the body in time, leading to continuous accumulation in the body, which may lead to serious side effects such as hypoglycemia.
four When a woman is pregnant. Most oral hypoglycemic drugs will enter the fetus through the placenta, causing adverse effects on the baby, so it is the best choice to switch to insulin at this time.
five Severe infection, before and after operation. When infected, the human body will secrete many substances “ Kill pathogens and protect yourself ” However, these substances may cause blood sugar to rise, making it difficult to control the original stable blood sugar. At this time, insulin is needed to control blood sugar. Antibiotics used during infection may have hepatorenal toxicity, such as streptomycin, rifampicin and other drugs used by tuberculosis patients, while oral hypoglycemic drugs are more or less metabolized through the liver and kidney Changing to insulin can avoid aggravating the burden of liver and kidney and protect the function of liver and kidney. Good blood glucose control is also required during operation to avoid postoperative infection. In addition, insulin can also promote wound healing.
In summary, 2 Patients with type 2 diabetes should not be afraid to switch to insulin therapy. The severity of diabetes does not depend on whether to use insulin treatment, but on whether there are serious complications. Insulin therapy can safely and effectively control blood sugar, avoid or delay the occurrence and development of complications, and improve the quality of life.
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