Activating whole blood clotting time (ACT) is an objective and effective method to detect blood clotting time during extracorporeal blood circulation surgery at home and abroad.The determination of ACT value can determine the dose of heparin anticoagulation and protamine antagonism required by blood, which is one of the effective means to ensure the safety and success of cardiac surgery.
Chinese name
Activate whole blood coagulation time
indication
Heparinization for cardiopulmonary bypass surgery
Normal value
Normal ACT physiological value is 90~130 seconds
Clinical significance
Indicators for monitoring anticoagulant efficacy of heparin during cardiopulmonary bypass
atlas
Science popularization in China
Committed to authoritative science communication
The certification expert of this term is
Liu Gang|Deputy chief physician
Department of Cardiology, Peking University People's Hospitalto examine
Indicators for monitoring anticoagulant efficacy of heparin during cardiopulmonary bypass
Indications
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1. Heparinization is required for cardiopulmonary bypass surgery: monitor the heparin dosage and protamine antagonistic dosage for cardiopulmonary bypass.
2. Monitor the heparin dosage and protamine neutralization dosage of patients with artificial kidney hemodialysis treatment and similar treatment, which are mostly found in patients who need immediate evaluation of heparin anticoagulation status, such as extracorporeal membrane oxygenation treatment, hemodialysis, cardiac catheterization and vascular surgery..
3. It is used to control the monitoring of heparin therapy in patients with thrombosis and embolic diseases. The ACT value is generally controlled between 150~210 seconds.
4. Monitor some patients who lack coagulation factors Ⅷ, Ⅸ and XI during special treatment.
Normal value reference range
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The normal physiological value of ACT is 90~130 seconds.
Clinical significance
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This method is often used to monitor the anticoagulant efficacy of heparin during cardiopulmonary bypass, and to calculate the dosage of protamine against heparin.
matters needing attention
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1. Carefully check whether the ACT monitor works well before use.
2. Too much or too little blood sample in the test tube will affect the determination results.
3. ACT monitor shall not be collided or vibrated.
4. Keep the operating environment clean and avoid local environment being polluted by blood source.
