Estrogen promotesFemale animalsDevelopment of secondary sexual characteristics andSexual organMature substance, composed of female animal ovary andplacentaSecretion.Estrogen receptors are distributed in the uterus, vagina, breastpelvic cavityAnd skinbladder, urethra, bone and brain. Therefore, estrogen has a wide and important physiological role, not only to promote and maintain the female reproductive organs and secondary sexual characteristics, but also toendocrine、cardiovascular, metabolic system, bone growth and maturation, skin, etc.Natural estrogen is mainly estradiolEstroneEstriol;The commonly used estrogen drugs in clinic are mostly based onEstradiolIt is a synthetic derivative of the mother, such as estradiol benzoate, estradiol valerate, ethinylestradiol, quinestrol, progesterone, etc.
Chinese name
estrogen
Foreign name
Estrogens[1]
type
Plant hormone, animal hormone
Physiological function
Promote the appearance of secondary sexual characteristics
1. EnclosureMenopauseSyndrome: estrogen can be used for replacement treatment.
2. Breast distention, pain and withdrawal: large doseestrogenIt can interfere with the action of prolactin, inhibit the secretion of milk, and relieve pain.
3. Ovarian insufficiency andamenorrhoeaEstrogen replacement therapy can promote the development of external genitalia, uterus and secondary sexual characteristics.Combined with progesterone, it can produce artificialmenstrual cycle。
fourosteoporosis: Use small doses for prevention and treatment.
5. Functional uterine bleeding estrogen can promote endometrial hyperplasia, repair bleeding wounds and stop bleeding. It can also be properly combined with progesterone to adjust the menstrual cycle.
6. Late stagemammary cancerPatients with advanced breast cancer who have been postmenopausal for more than five years should be treated with estrogen, but it should not be used in patients before menopause.
clinical application
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Follow your doctor's advice.
Adverse reactions
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Large doses can cause nausea, vomiting, breast painendometriumHyperplasia and uterine bleeding.Long term high-dose use may increase the risk of breast cancer, estrogen alone may increase the risk of endometrial cancer, and may increase the risk of cardiovascular and cerebrovascular diseases, venous thrombosis.
Drug contraindication
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Known or suspectedgestationVaginal bleeding or endometrial hyperplasia with unknown causes, breast cancer, and malignant tumors related to sex hormones;Active within 6 monthsveinOr arterial thromboembolic disease, severe liverrenal functionObstaclesHematoporphyrinSymptomsOtosclerosisIt is forbidden for patients with systemic lupus erythematosus.
Note: The above contents are only for introduction. Drug use must be carried out by regular hospitals under the guidance of doctors.
