Acyl group refers toOrganicorinorganicOxyacidRemovehydroxylThe remaining priceAtomic clusterThe general formula is R-M (O) -.stayOrganic chemistryThe acyl group mainly refers to the group with structure.Aldehydes, ketones, carboxylic acids, carboxylic acid derivatives, etc. almost all have acyl groups.Usually, the M atom in the acyl group is carbon, but sulfur, phosphorus, xenon and other atoms can also form similar acyl compounds, such asXenon tetrafluoro monooxide、Thionyl chloride、Sulfoxide chloride。Such acyl halides are generally called halogen oxides.
carbonylThe difference between carbonyl group and acyl group: carbonyl group is an atomic group that can connect two bonds to the group, while acyl group is an atomic group that has one end connected to a hydrocarbon group, leaving only the other end empty.
Acylation
The acyl group is not a group that distinguishes the category of organic matter.Organic compoundThe reaction of introducing acyl groups to nitrogen, oxygen, carbon and other atoms in the molecule is generally referred to asAcylation, but habituallycarbon atomNitroSulfonyl groupandcarboxyl(The carboxyl group can be used as the acyl group of carbonic acid)nitrification、sulfonationAnd carboxylation.
Sulfonyl drugs account for a considerable proportion in clinical therapeutic drugs. Introducing sulfonyl groups into small molecules is one of the important strategies for drug molecular structure modification.The application of sulfonyl group in drug molecular design. In terms of structure, sulfonyl group has similar size and charge distribution with carbonyl group, carboxyl group, tetrazole group and phosphate group, which can be used as theirBioelectronic isotopesIt is introduced into small molecules to maintain or enhance thebiological activity。
The sulfonyl group has unique physical and chemical properties. The introduction of sulfonyl group can adjust the solubility and acid-base property of small molecules;The sulfonyl group can provide two hydrogen bond receptors, and the reasonable introduction of sulfonyl group can improve the compound'sbiological activity； The structure of sulfonyl group is relatively stable. The introduction of sulfonyl group can improve the stability of drug metabolism, prolong its action time, improve its bioavailability, and improve the bioavailability of small molecules by blocking easy metabolism sitesPharmacokineticsnature.
Caffeoylquinic acid
Caffeioyl quinic acid compounds are a kind of phenolic natural compounds condensed from quinic acid and one or more caffeic acids through esterification reaction. They are widely found in plants and have a variety of pharmacological activities, such as antioxidant, anti-inflammatory, antimicrobial, enzyme inhibition and liver cell protection.
Acyl phosphine oxide
UV curable coating is an energy-saving, low pollution, high efficiency and suitable for continuous mass production of coating varieties, known as environmentally friendly coatings.Photoactive oligomer（Photosensitive resin）Active diluting monomer and photoinitiator are the basic components of the UV curing formula, as well as additives and other additives.The initiation efficiency of photoinitiator is very important to the cost of photocuring formula and the photocuring rate.The development of UV curable coatings depends on the development of photoinitiators in a sense.
Although there are many kinds of photoinitiators that can be used in UV curing coatings on the market, most of them are difficult to be used in coatings containing pigments. For a long time, the curing system of colored pigments in UV and visible light has been a problem.Because of its unique absorption wavelength, acyl phosphine oxide has extended its absorption range to the visible light region, and even can absorb enough light energy in the presence of white pigments to provide efficient initiation performance.In addition, there will be no yellowing after curing, which is not available in other photoinitiators initiated by α - dissociation, so it has good application in white furniture coatings and thicker coatings.[2]
