The laboratory is based on the diversified ethnic minorities and rich animal genetic resources in southwest ChinaEvolutionary biologyBased on the profound accumulation of research, combined with national needs and the development trend of international related disciplines, by strengthening China's basic research on genetic resources, a strategic resource, to promote the cross and unified research on genetics, development and evolution, and to expand the research on functional generation and evolution in biological evolution, the aim is to effectively promote China'sGenetic diversityThe development of evolutionary genomics and evolutionary development provides a theoretical basis for the protection and sustainable use of genetic resources, and supports the sustainable development of China's biological, medical and pharmaceutical industries;Through the development of new disciplinary growth points, it aims to become the center of genetic resources and evolution research in China, and occupy a place in the world, so as to drive and lead Kunming Institute of Zoology, Chinese Academy of Sciences, to give play to its characteristics and advantages, and to comprehensively move forward to the international first-class research institutes of the same kind.
research field
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1. Evolution and protection of genetic resources diversity: further collect genetic resources, especially the rich genetic resources of ethnic minorities and animals in southwest China, study the formation and evolution of genetic resources (diversity), especially the endangered mechanism of rare species and their protection strategies, and the relationship between the diversity and domestication of genetic resources of wild and domestic animals,To provide scientific basis for the protection and rational utilization of genetic resources;
2. The evolution of genes and genomes: take biological groups with different key evolutionary positions as the research object, study the laws of gene origin and evolution, the significance of gene adaptive evolution to environmental adaptation, the evolutionary model of gene functional pathways and networks, the basis of gene family structure and functional evolution and its evolutionary model and mechanism, the origin and evolution of genomes, and explore genesThe formation mechanism and evolution law of the structure and function of gene family and genome in the process of biological evolution;
3. Genetic development and evolutionDevelopmental biologyMechanisms, such as new genes, new gene expression and regulation mechanisms, contribute to species morphological evolution and adaptability.
Academic team
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Among the current 11 research leaders (PIs) in the laboratoryAcademician of CAS1, 2 talents introduced in the "Hundred Talents Program" of the Chinese Academy of Sciences, 2 leaders of the China Germany Mapu Young Scientists Group of the Chinese Academy of Sciences,National Science Fund for Distinguished Young Scholars4 winners.At present, there are 23 technical assistants and nearly 100 graduate students.It has master's, doctoral and postdoctoral workstations.
Project achievements
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Since 2001, the laboratory has published more than 300 SCI research papers and 26 SCI papers with impact factor>10, including research papersNature2Science1, Nature Genetics;One Nature Review Genetics, two Nature Reviews and one Science Review were invited to comment and summarize, which attracted wide attention and positive comments from international peers.The average impact factor of a single paper is 4.5, and the cumulative number of citations is nearly 1000.It has won one American Biodiversity Leadership Award, one Science and Technology Progress Award from the Ho Leung Ho Lee Foundation, six first prizes of provincial and ministerial level natural science awards, two second prizes of national natural science awards, and one outstanding contribution award of Yunnan natural science.Three doctoral students won the Special Award of the Dean's Scholarship of the Chinese Academy of Sciences, and two won the National Hundred Excellent Doctoral Dissertations Award.
From 2006 to 2010, the laboratory undertook 181 national and provincial (departmental) scientific research projects, including 2 973 projects presided over and 4 participated in;Three major national science and technology projects and two national science and technology support plans;Innovative research group of National Natural Science Foundation of China1 project, 3 Science Fund for Distinguished Young Scholars, 2 major research projects and 8 key projects;3 major international cooperation projects;9 major innovation projects of the Chinese Academy of Sciences[1]。
The laboratory has undertaken the construction of the animal sub library of the national major scientific project "Southwest China Wildlife Germplasm Resources Bank", and has made significant progress in the collection of biodiversity resources. On this basis, the laboratory has taken the lead in organizing China's life barcode program, making China one of the four central nodes of the "iBOL International Major Program",He also led the organization of the "International Goat Genome Project" and participated in the organization of major international projects such as the "International Sheep Genome Project" as a major member, which had important international influence.Since 2006, the laboratory has organically combined resource advantages with scientific frontiers. Focusing on key scientific issues such as the evolution law of genetic resource diversity, the genetic mechanism of natural/artificial selection and biological adaptation, it has formed a batch of representative achievements with international influence in the pattern, process and mechanism of biodiversity evolution, and has published 318 SCI papers, including Nature,Science, Nat. Biotechnol., PNAS and other international top academic journals published 34 papers, including 20 papers by the first author (including co first author) or correspondence author (including co correspondence author).The average impact factor of the paper is 4.3, the average number of citations is 5.3, and the maximum number of citations for a single article is 116.In addition, the laboratory has also made major breakthroughs in the protection, recovery and sustainable utilization of genetic germplasm resources of endangered species, which has been reviewed by Nature, Science, Nature Rev. Genet. and other magazines.The laboratory also participated in the preparation of 7 monographs and applied for 4 patents.Since 2006, the laboratory has obtainedNational Natural Science AwardTwo second prizes, three first prizes of provincial and ministerial natural science awards, one second prize and one third prize respectively, and one third prize of Yunnan Science and Technology Achievement Award (technological invention category)[1]。
By 2012, the laboratory had 15 research groups, 3 supporting departments, and 99 fixed researchers. It was a high-quality research team composed mainly of young and middle-aged people (with an average age of 35 years).Among the 15 discipline leaders (PIs), there are 1 academician of the Chinese Academy of Sciences, 4 winners of the National Science Fund for Distinguished Young Scholars, 3 national candidates for the Hundred Thousand Talents Project, 7 talents for the Hundred Talents Program, 2 leaders of the Young Scientists Group of the Chinese Academy of Sciences and the German Max Planck Society, and 2 high-end scientific and technological talents in Yunnan Province.Science and Technology Progress Award of He Liang He Li FoundationOne winner, Wang Kuancheng, Chinese Academy of Sciences, Western Scholar Outstanding Contribution Award, and Yunnan Natural Science Outstanding Contribution Award.In addition, there are 11 associate researchers and more than 20 young researchers with doctor's degree under the age of 40.The laboratory also has 4 master's programs, 3 doctoral programs, 1 postdoctoral workstation, and more than 100 graduate students and postdoctoral students.Since 2006, one person has won one hundred excellent doctoral dissertations nationwide, four excellent doctoral dissertations of the Chinese Academy of Sciences, and one special award of the Dean's Scholarship of the Chinese Academy of Sciences[1]。
The laboratory has more than 300 instruments and equipment of various sizes for cell and molecular evolution research, including the gene chip scanner Affymetrix GC3000, the gene typing system Beckman Genotyping System, the inverted fluorescent microscope Leica DMI6000B, the two-dimensional electrophoresis GE/Ethan DIGE System, the high-performance computer group Dawning 4000A, the DNA sequence analyzer ABI 3130xlRoche 454 sequencer and other large-scale instruments.On this basis, a high-throughputDNA sequencingPlatform, bioinformatics large-scale computer analysis platform, gene function analysis platform, proteomics analysis platform, and high-throughput genotype analysis platform.In order to meet the needs of the laboratory for genome evolution and gene function research in the post genome era.These platforms are also open to the public.In addition, the laboratory also has Wuliang MountainBlack gibbonThere are 4 field observation stations, such as the monitoring station, Shuangbai Monitoring Station of Ailaoshan National Nature Reserve Wildlife Research Base, and 3 Yunnan indigenous fish breeding bases.It provides important support for the innovative development of the laboratory[1]。
