State Key Laboratory of Protein and Plant Gene Research (Peking University)

Peking University

synonym State Key Laboratory of Protein Engineering and Plant Genetic Engineering (Peking University) (State Key Laboratory of Protein Engineering and Plant Genetic Engineering (Peking University)) generally refers to the State Key Laboratory of Protein and Plant Gene Research (Peking University)

Supported by the State Key Laboratory of Protein and Plant Gene Research Peking University 。 To adapt life sciences The rapid development of National Planning Commission Approved in 1987 on Department of Biology, Peking University establish State Key Laboratory of Protein Engineering and Plant Genetic Engineering 。 The laboratory began its preparation in January 1987, passed the national acceptance in September 1990 and was open to the public at home and abroad. The leadership of the laboratory changed after the evaluation in 2001. Ministry of Science and Technology GKFJ [2010] No. 747 approved the laboratory to be renamed "State Key Laboratory of Protein and Plant Gene Research". The laboratory was established by the President of Peking University Xu Zhihong Academician serves as the director of the new academic committee, Zhu Yuxian The professor is the director of the laboratory.

Chinese name: State Key Laboratory of Protein and Plant Gene Research (Peking University)
School: Peking University
Approval time: 1987

Preparation time: Since January 1987
Opening Hours: September 1990
Fixed personnel: 39 persons
International cooperation projects: 15 items
Location: Beijing

catalog

Scientific research team

Announce

edit

At present, the laboratory has 39 permanent staff, most of whom are young and middle-aged scholars, including 16 professors, 5 associate professors, 8 lecturers, 4 distinguished professors of the "Yangtze River Plan", and 16 young academic backbones with doctoral degrees. According to the needs of national economic construction and the development of science, technology and education, based on the advanced theory and technology frontier of international discipline development, the laboratory carried out macromolecule Relationship between structure and function molecular biology And basic theoretical research and applied basic research on gene expression regulation, trying to apply new technologies and methods of modern bioengineering to agriculture and pharmaceutical production. From 1996 to 2000, our scientific researchers presided over 3 secondary sub topics of major national basic research projects and participated in 3 projects. Presided over two major projects of the Ministry of Science and Technology "transgenic plant project". He has presided over 19 863 projects, 19 general projects of the National Natural Science Foundation of China, 2 key projects, 4 National Science Fund for Distinguished Young Scholars, and 15 international cooperation projects, and has received 60 million yuan of scientific research funds. He has published 275 papers in major academic journals at home and abroad, including 105 papers included in SCI and 10 Chinese monographs. stay Document and Information Center of Chinese Academy of Sciences Among the top ten national key laboratories with the highest number of cited papers published in 1999, our laboratory ranked fourth.^[1-2]

academic exchange

Announce

edit

The laboratory has hosted 11 domestic, international and bilateral conferences, participated in 126 international academic conferences, and attended 140 people. 92 foreign scholars came to the laboratory to give lectures. It has good contacts and cooperation with universities and research institutions in the United States, Britain, Japan, France, Germany, Italy, Hong Kong SAR and other countries Peking University —— Yale University Plant Molecular Genetics and Agricultural biotechnology Joint Research Center and Peking University —— The Chinese University of Hong Kong Joint Laboratory of Plant Genetic Engineering.

research findings

Announce

edit

In the last five years, the laboratory has for the first time comprehensively analyzed birds (high altitude, hypoxia tolerant bar headed geese) hemoglobin The particularity of its allosteric mechanism is clarified. The crystal structure of the coat protein of plant reovirus and rice dwarf virus was analyzed for the first time, and the role of the A chain small ring of insulin molecule and the S-S between A-B chains in peptide chain folding and recombination, as well as the possible intramolecular molecular chaperone role of C-peptide were theoretically explored. yes Metallothionein The theoretical and transgenic studies of prourokinase or its mutants have shown that they have obvious application prospects in medicine, agriculture and environmental protection. We took the lead in National 863 Program With the support, it has carried out bioinformatics research and become a national node in China on EMBNet, established the first bioinformatics research center in China, and established a leading domestic and internationally advanced public database. We also plan to attract high-level talents with complementary business expertise and international competitiveness to form a team, strive to undertake domestic and foreign scientific research tasks, and actively participate in the competition of international cutting-edge hot spots. A high-density mutant library of Arabidopsis thaliana has been constructed, 45000 mutants per plant have been screened, and 2500 fragments have been sequenced and mapped. Isolated from rice Trypsin inhibitor The gene product can inhibit the growth of Magnaporthe grisea in vitro. The study found that the gene exists in the form of a gene family, with seven members distributed on about 35 kb rice DNA fragments. The expression profile of the gene in different tissues, organs and development stages of rice is completely different. The genetic analysis of these genes showed that they may come from gene duplication and domain displacement. After disease resistance testing in Beijing and Yunnan, two transgenic lines were found to have strong resistance to rice blast. We will further study the role of different members in rice development and defense. Using G2 pea mutant strain as material, we successively cloned several genes related to individual anti-aging, and found that PPF1 gene has calcium ion channels Protein function, suggesting that calcium concentration may participate in the regulation of plant growth and development process. Using organ specific promoter to drive Cre lox system, Barnase gene expression control in specific stages of plant male organs or seed development is realized, resulting in controllable male sterility or seed abortion. Our research also confirmed that CRP, the general regulatory protein of carbon metabolism, inhibits most σ 54 dependent promoters, while different carbon sources affect the Kjeldahl Pneumonia The nitrogen fixation ability of the.

In the future, we should highlight the key development direction and actively deepen the reform of scientific research system according to new ideas to adapt to the current situation life sciences The trend of interdisciplinary and comprehensive research aims to produce as many large and breakthrough research achievements as possible. We should speed up the training, selection and introduction of outstanding young and middle-aged academic leaders, and build a young scientific research backbone team that can cross the century and shoulder important tasks in the country and key disciplines. Further improve the living conditions of scientific researchers to ensure their good working and living conditions.

Novice on the road

Growth task Getting Started with Editing Edit Rule Edit by myself

I have questions

Content query Online Service Official post bar Feedback

Complaints and suggestions

Report bad information Failed to appeal through entries Complaint of infringement information Blocking query and unblocking

Jinggong Network Anbei No. 1100000200001