Alginic acid existsKelp、Giant algaetc.Brown algaeA natural polyuronic acid in the cell wall.Chemical formula (CsixHeightOsix)n[1-2]。From β - D-Mannuronic acid(M) The linear copolymer formed by 1,4-bonding with α - L-guluronic acid (G), the content of G and M in alginate has obvious influence on the gelling performance of the fiber.Alginate exists in the cytoplasm in natural state and plays a role in strengthening the cell wall.Alginate combines with various cations in seawater to form various alginate salts.Extracts from seaweeds are usuallysodium alginate 。Sodium alginate has the characteristics of thickening, suspending, emulsifying, stabilizing, forming gel, forming film and spinning fiber. It has a long and wide use in food, paper making, cosmetics and other industries, especially in recent yearsbiomedical engineeringDomain discovery has important uses.[3]
(1) Take about 30mg of this product, add 5ml of sodium hydroxide solution (0.1mol/L), shake to dissolve it, addcalcium chlorideTest solution 1ml, withGlass rodStir to produce gelatinous sediment and stick it to the glass rod.
(3) Take about 10mg of this product, add 5ml of water, and add 1% 1, 3 newly prepared-Dihydroxy group1ml of naphthalene ethanol solution and 5ml of hydrochloric acid, shake well, boil for 5 minutes, cool down, and transfer to 60mlSeparating funnelThe container is washed with 5ml of water, the washing solution is incorporated into the separating funnel, andIsopropyl ether15ml, shake and extract, separate the ether layer, and make a blank control at the same time. The isopropyl ether layer of the sample tube should be dark purple when compared with the control tube.
InspectionacidityTake 1.5g of this product, add 50ml of water, and shake for 5 minutes
Starch Take 0.1g of this product, add 100ml of sodium hydroxide solution (1 → 2500), shake to dissolve, take 5ml, add 1 drop of iodine test solution, and no transient blue color shall be produced.
Loss on dryingTake this product and dry it at 105 ℃ for 4 hours. The weight loss shall not exceed 15.0%
Ignition residueTake 0.5g of this product, and the residue shall not exceed 5.0%.
ferric saltTake 1g of this product, burn it slowly until complete carbonization, and burn it at 500~600 ℃ until complete carbonizationashingAdd 3ml of hydrochloric acid to dissolve the residue and transfer it into a 50ml measuring bottle, add water to the scale, shake well, accurately measure 5ml, put it into Nessler's colorimetric tube, add water to make 25ml, if color develops, it shall not be deeper (0.05%) than the control solution made of 5ml of standard iron solution.
heavy metalTake the residue left under the item of burning residue, and check according to law that the content of heavy metals shall not exceed 40% per million.
Take 0.5g of arsenic salt and addAnhydrous sodium carbonate0.5g, mix well, add a small amount of water to moisten, burn slowly with a small fire until completely ashed, cool down, add a small amount of hydrochloric acid until the residue no longer produces bubbles, add 5ml of hydrochloric acid, dissolve with 23ml of water, and the arsenic content shall not exceed 3 parts per million.
viscosityAt 20 ℃, take 1% aqueous solution of the product, adjust it to neutral with sodium hydroxide test solution, and measure the viscosity with a rotary viscometer (select rotor 2, rotating speed 30n/min or 60n/min). The viscosity should be less than 50 × 10<- 3>Pa<[0]>s.
acid valueTake 0.5g of this product, weigh precisely, add 50ml of water and 30ml of calcium acetate solution (0.25mol/L), shake well, place for 1h, addPhenolphthalein5 drops of indicator solution, use sodium hydroxide solution (0.1mol/L)titration, and use the titration resultBlank testThe acid value shall be calculated according to the following formula:
(A-B)×M×56.1
Acid value=--------
W(1-L)
A: Volume of sodium hydroxide solution (0.1mo1/L) consumed by the sample (ml)
B: Volume of sodium hydroxide solution (0.1mo1/L) consumed in blank (ml)
M: Molar concentration of sodium hydroxide solution
W: Weight of sample (g)
50: Moisture of sample (%)
Incompatibility
Announce
edit
Not compatible with strong oxidants. Alginate is not compatible withalkaline-earth metalIn the presence of ions and Ⅲ group metal ions, insoluble salts can be formed.
Other precautions
Announce
edit
[Function and purpose]excipient, adhesive, gastric acid reflux inhibitor.
[Storage] Sealed storage.
[Usage and dosage]
(1) In case of strong acid, alginate will be released;
(2) It is safe and non-toxic, and the daily intake is 0.25mg/kg.
preparation
Announce
edit
commonBrown algaeSuch as sea beltSargassum, Phyllophyllum sppGiant algaAre the main source of alginate.seaweedAlginate is prepared by reacting the extract with strong acids such as sulfuric acid after treatment with sodium hydroxide.AzotobacterandPseudomonasIt can also be used for biosynthesis of alginate. Generally, alginate synthesized by bacteria can produce micron or nanometer structure forbiomedical engineeringfield[4]。
In the pharmaceutical industry, alginate is a commonly used excipient: its viscosity makes it the adhesive of tablets;Because it expands with water, it is also used asDisintegrantDisperse the tablet in the human body;Or asdispersantDispersing active ingredients into liquidSuspension；Alginate is used as medicineSlow release agent。Dental use it to replace plaster and rubber, making dental mold.Alginate itself can be treated as an absorbentHeavy metal poisoning[5]。
