Anisole

Organic compound

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Anisole fennel Ether, a Organic compound , chemical formula is C seven H eight O， With pleasant fennel like aroma, used for Organic synthesis , also used as solvent, spice and Insect repellent 。

Chinese name: Anisole
Foreign name: Anisole
Alias: Methoxybenzene 、 Anisole 、 methyl phenyl ether
chemical formula: C seven H eight O
molecular weight: one hundred and eight point one three eight
CAS login number: 100-66-3
EINECS login number: 202-876-1
Melting point: -37.3 ℃

Boiling point: 153.8 ℃
Water solubility: Insoluble
Density: 0.995 g/cm³
Appearance: colorless liquid
Flash point: 52 ℃ （OC）
Application: Used in organic synthesis, as well as solvent, perfume and insect repellent
Security description: S16；S24/25；S26；S37/39
Hazard symbol: Xn
Hazard description: R10；R20；R38

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Physical and chemical properties

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Density: 0.995g/cm three

Melting point: - 37.3 ℃

Boiling point: 153.8 ℃

Pilot temperature ：475℃

critical pressure ：4.25MPa

Flash point: 52 ℃ (OC)

Refractive index ：1.516（20℃）

Saturated vapor pressure ：1.33kPa（42.2℃）

Upper explosive limit （ V / V ）：6.3%

Lower explosive limit （ V / V ）：0.3%

Appearance: colorless liquid body

Solubility : insoluble in water, soluble in ethanol 、 Ether Equal majority Organic solvent

Molecular structure data

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Molar refractive index ：32.93

Molar volume （cm three /mol）：113.4

Isotonic capacity （90.2K）：263.9

surface tension （dyne/cm）：29.3

Polarizability （10 -24 cm three ）：13.05

Calculate chemical data

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Calculation of drainage parameters reference value (XlogP): None

Number of hydrogen bond donors: 0

Number of hydrogen bond receptors: 1

Rotatable Chemical bond Quantity: 1

Tautomer Quantity: 0

topology molecule Polar surface area ：9.2

Heavy atom Quantity: 8

surface charge ：0

Complexity: 55.4

Isotope atom Quantity: 0

Determine the number of atomic structure centers: 0

Number of uncertain atomic structure centers: 0

Determine the number of chemical bond structure centers: 0

Number of uncertain chemical bond structure centers: 0

covalent bond Number of units: 1

toxicology data

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1、 acute toxicity ：LD fifty ：3700mg/kg（ Rat Oral); 2800 mg/kg (mouse by mouth).

2. Irritation: rabbit Percutaneous: 500mg (24h), moderate irritation.

3、 Mutagenicity ： DNA Suppression: people lymphocyte 25μ mol/L 。

Ecological data

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Biodegradability : MITI test showed that the initial concentration was 100ppm, and after two weeks, the degradation rate was 56%, and the BOD removal rate continued to rise.

Abiotic Degradability: in air, when Hydroxyl radical The concentration is 5.00 × 10 five Pcs/cm three Degradation half life 22h (theoretical).^[1]

application

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Used in organic synthesis, as well as solvent, perfume and Insect repellent 。

First aid measures

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Skin contact: Take off the contaminated clothes and wash the skin thoroughly with soapy water and clean water.

Eye contact: lift the eyelid, use flowing water or normal saline rinse. Get medical attention.

Inhalation: quickly leave the site to a place with fresh air. keep respiratory tract unobstructed. as dyspnea , give oxygen. as Apnea , perform artificial respiration immediately. Get medical attention.

Ingestion: drink enough warm water to induce vomiting. Get medical attention.

Fire fighting measures

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Harmful Combustion products ： carbon monoxide 、 carbon dioxide 。

Fire extinguishing method: Water spray cooling Container, if possible, move the container from the fire site to an open place.

Extinguishing agent: foam, carbon dioxide, dry powder, sand. Fire extinguishing with water is invalid.

Leakage emergency treatment

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Evacuate the personnel in the leakage contaminated area to a safe area quickly, isolate them, and strictly restrict access. Cut off the ignition source. proposal Emergency Management Personnel shall wear self-contained positive pressure respirators Antistatic clothing 。 Cut off the leakage source as much as possible. Prevent inflow sewer 、 Flood discharge ditch And so on.

Small amount of leakage: absorb or absorb with sand or other incombustible materials. Incombustibility can also be used dispersant Brushing with the prepared emulsion, Lotion After dilution, it is put into the waste water system.

Large amount of leakage: build a dike or dig a pit to receive. Cover with foam to reduce steam disaster. Transfer to tank car or special purpose with explosion-proof pump collector Inside, recycle or transport to waste disposal Site disposal.

Handling storage

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Operation precautions: closed operation, General ventilation 。 Operators must be specially trained and strictly abide by Operating Procedures 。 Recommended for operators Filter gas mask （ Half mask ）, Dai Chemical Safety goggles Wear anti-static work clothes Rubber oil resistant gloves 。 Keep away from kindling and heat source, Workplace Smoking is strictly prohibited. 。 Use explosion-proof ventilation system And equipment. Prevent vapor leakage into the air of the workplace. Avoid contact with oxidants and acids. The flow rate shall be controlled during filling to prevent electrostatic accumulation 。 Load and unload gently during transportation to prevent damage to packaging and containers. Equipped with corresponding varieties and quantities Fire Equipment and Leakage emergency treatment Equipment. Empty containers may leave harmful substances.

Precautions for storage: store in a cool and ventilated warehouse. Keep away from kindling and heat sources. The warehouse temperature should not exceed 30 ℃. Keep container sealed. It shall be stored separately from oxidants and acids, and mixed storage is strictly prohibited. Explosion proof lighting and ventilation facilities shall be adopted. It is forbidden to use those easy to generate sparks mechanical equipment And tools. The storage area shall be equipped with leakage emergency treatment equipment and appropriate materials.