Spontaneous hypertensionrat(Spontaneously hypertensive rates, SHR) is a male Wistar Kyoto strain rat with a systolic blood pressure of 150~175mmHg andshrinkFemale Wistar Kyoto rats with a pressure of 130~140mmHg mate to obtain offspring whose systolic blood pressure is more than 150mmHg. Then select rats with higher blood pressure for inbreeding, and carry out this selective inbreeding for 20 generations in order to obtain stableHypertension hereditySex, thus establishing SHR varieties.
By 1986, SHR had bred 80 generations.After birth, the blood pressure of SHR increases with the age of the rat. The hypertension is established at 3 to 4 months, and the blood pressure rises to the highest level at 6 months. The sympathetic activity of SHR in childhood increases. Although the blood pressure is normal at 4 weeks, the heart weight has increased. Later, cardiovascular complications further appear with the increase of blood pressure.The normal blood pressure control group of SHR is WKY (Wistar Kyoto rates), but there are manyresearcherIt is believed that WKY is not ideal as a control group, because WKY has a high incidence of spontaneous hypertension, and WKY is cultivated 10 years later than SHRreproductionThe number of generations is not enough. It was commercialized and put into each laboratory before stable heritability was established, resulting in large genetic differences in WKY among laboratories.
thisratIn addition to the 100% spontaneous rate of hypertension, there are also hypertensive cardiovascular diseases.SHR is most widely used in various hereditary hypertensive rats. The rise of blood pressure in SHR is determined by polygene inheritance, which is very similar to human hypertension. It is an ideal animal model for studying the pathogenesis of hypertension and screening antihypertensive drugs.The similarities between the two are as follows: ① genetic factors play an important role; ②There is no obvious organic change in the early stage of hypertension; ③The condition is similar. The blood pressure increases with the age of rats, and has reached the highest level by 6 months; ④The characteristics of hemodynamic changes were consistent, and the total peripheral resistance of blood vessels increased significantly; ⑤Complications such as heart, brain and kidney may occur with the development of the disease. Treatment measures such as antihypertensive drugs can prevent or reduce the progress of the disease and the occurrence of complications; ⑥Stress and excessive salt intake can accelerate the development of hypertension and aggravate complications.However, SHR has some differences with human hypertension, which are shown as follows: ① it is mainly obtained through selective reproduction in genetics, which is different from the occurrence of hypertension; ②Thyroid and immune function are abnormal.
