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Mumps virus

Pathogen of epidemic parotitis
mumps The viruses are Epidemic parotitis Of pathogen Mumps are prevalent all over the world. It is an acute disease commonly seen in children Respiratory infectious disease It usually occurs in winter and spring. [1]
Chinese name
Mumps virus
Foreign name
mumps virus
section
Paramyxovirus section
genus
Paramyxovirus
Definition
Pathogen of epidemic parotitis

Biological characteristics

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Mumps virus belongs to Paramyxovirus Family, Paramyxovirus. The virus is spherical with a diameter of 100-200 nm, genome by Single strand negative strand RNA capsid present Helical symmetry HA and NA Isoprotic, composed of glycoprotein So far, only one serotype of mumps virus has been found. The virus can Chicken embryo Amniotic cavity It can also proliferate in monkey kidney cell culture Medium proliferation, can make cell fusion formation Multinucleated giant cell Mumps virus affects heat, lipid solvents and ultraviolet rays It is sensitive, but resistant to low temperature. It can survive for 3 months at 2 ℃ and more than one year at - 60 ℃.

Pathogenicity and immunity

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(1) Pathogenicity
parotid gland Inflammation is a common disease in children with parotid gland swelling and pain as the main symptoms, which is distributed worldwide. It usually occurs in winter and spring. The etiology and immunology of school age children are Susceptible person mumps Viruses Only infected people, Infectious agent It is carried by patients and viruses, mainly through Feizhu, and can also be spread through direct contact between people. incubation period Long, generally 2-3 weeks. After virus invades human body respiratory tract It proliferates and then enters the blood stream, causing disease Toxemia , diffused to salivary glands And other organs such as pancreas, testis, ovary, kidney and center nervous system Etc. Epidemic parotitis infectivity Strong. Patients before and within one week after the onset of the disease are highly infectious. The patient shows weakness Anorexia One or both parotid glands are enlarged with pain and fever The course of the disease lasts for 1~2 weeks, and the adolescent is infected. Male is prone to complications Orchitis , resulting in Testicular atrophy And primary education; Women are easy to merge Oophoritis , infection of pregnant women within 3 months of pregnancy can cause Fetal malformation
(2) Immunity
The patient can obtain strong immunity after illness, Passive immunity Available from parent. Therefore, mumps in infants less than 6 months old are rare.

Microbiological examination

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For atypical cases, saliva, urine or cerebrospinal fluid The virus can be isolated from other samples, and double sera can also be used for detection Specificity Dynamic changes of antibodies, or use immunofluorescence technology to detect viral antigens.

Prevention and control principle

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Vaccination Is the only valid preventive measure Common Live attenuated vaccine , or measles virus Rubella virus , mumps virus Triple vaccine MMR )Proceed Vaccination For patients with mumps. It shall be isolated in time to prevent the spread of disease. At present, there is no effective drug treatment. Commonly used in traditional Chinese medicine Puji Disinfection Drink and Forsythia Baidu Powder So strengthen the treatment, with cactus local external application also has a definite effect. [1]