The ribosome cycle of protein biosynthesis includes three steps: carry, peptide and transposition.
Peptide forming: The process of forming peptide chains between two amino acids under the catalysis of peptidyltransferase (transpeptidase).
Peptidyltransferase: The chemical essence is RNA, so it belongs to a ribozyme.
Catalytic process
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staymRNAWhen translated into peptide chain,Peptide bondThe formation of is automatic and does not require additional energy. This reaction is catalyzed by peptidyl transferase, which catalyzes the A-position of ribosometRNAUpper endamino acidOfaminoAnd amino acid on peptidyl tRNA at P positioncarboxylInterphase formationPeptide bond。As a result, theAminoacyl tRNAOnpolypeptideAn extension ofamino acid, while P bitAminoacyl tRNAFormation of deamination acyl-tRNA。The enzyme is a component of ribosomal 50S subunit.For many years, it has been thought that peptidyltransferase is a kind of protein that makes up the 50S subunit. It has been clearly understood that it is RNA that makes up the ribosomeribozyme。It is generally believed thatRibosome large subunitRRNA in.
