hepatitis

[gān yán]
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Disease name
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Korean English (Chief physician) Department of Gastroenterology, General Hospital of Beijing Military Region
Hepatitis is a general term for liver inflammation. Usually refers to multiple pathogenic factors such as Viruses , bacteria parasite , chemical poisons, drugs, alcohol Autoimmunity Factors such as liver cell damage, liver function damage, and a series of uncomfortable symptoms of the body, and liver function The indicator is abnormal.
Although there are similar causes of hepatitis clinical manifestation , but in Etiology serology , injury mechanism, clinical process and prognosis , extrahepatic damage, diagnosis and treatment are often significantly different.
It should be noted that most of the so-called hepatitis in our life refers to hepatitis A, hepatitis B, hepatitis C, etc hepatitis virus Caused by Viral hepatitis
The increase of unexplained childhood hepatitis cases since 2022 is related to adeno-associated virus type II (AAV2), a common childhood virus [9]
TCM disease name
hepatitis
Foreign name
Hepatitis
Visiting department
Infection Department, Hepatitis Department, Digestive Department
Common causes
Caused by viruses, bacteria, parasites, drugs, alcohol and other factors
common symptom
Loss of appetite, abdominal distension, aversion to greasy food, nausea, vomiting, and fatigue
infectivity
yes
Route of transmission
Viral hepatitis is infectious and can be transmitted through contact in daily life, blood borne transmission, mother to child transmission, iatrogenic transmission and sexual contact

classification

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1. According to etiology
It can be divided into viral, bacterial (such as amoeba) drug, alcoholic, toxic, self Immunity , non-alcoholic fatty, etc.
2. According to the duration of the disease
It can be divided into acute hepatitis chronic hepatitis Etc.
3. According to the presence or absence of jaundice
Acute hepatitis can be divided into Acute icteric hepatitis and Acute icteric hepatitis
4. According to the severity of the disease
Chronic hepatitis can be divided into mild, moderate and severe.

clinical manifestation

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1. Symptoms
The clinical manifestations of hepatitis vary from cause to cause. Common symptoms include: Anorexia abdominal distention , weariness Greasy food
Nausea, vomiting and fatigue.
2. Physical signs
Some patients have yellow sclera or skin, fever Occult pain in hepatic region Hepatomegaly , tenderness, some patients Spider nevus and Liver palms Severe hepatitis so ascites Oliguria Bleeding tendency and Consciousness obstacle , coma, etc.

inspect

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(2) Serological examination (Detection of virus specificity Marker , which helps to classify viral hepatitis).
(3) Other relevant inspections( routine blood test renal function , protein, fat and Carbohydrate metabolism Serum immunology test Etc.).
two Imaging inspect
It has great value in the diagnosis of various types of hepatitis. It can be scored by liver tissue electron microscopy, immunohistochemistry and Knodell HAI Systematic observation , correct data can be obtained on the etiology, etiology, inflammatory activity and fibrosis degree of hepatitis, which is beneficial to clinical diagnosis And differential diagnosis.

diagnosis

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According to the medical history, clinical manifestations and examination results.

treatment

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According to the etiology, course and severity of hepatitis, different treatment principles and measures should be taken.

Hepatitis cases

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Europe and America Multiple countries report unknown etiology Child hepatitis case
In April 2022, Britain, Spain Ireland The United States reported that hepatitis cases with unknown etiology were found among children, and new coronavirus was detected in some cases Viruses or adenovirus However, these viruses are found in hepatitis cases Pathogenesis The role of is unclear. [1]
On April 28, 2022, three cases were found in Japan. Ministry of Health of Singapore A 10 month old boy was reported to have similar symptoms.
On May 2, 2022, Indonesia Ministry of Health Three children with hepatitis of unknown etiology were reported.
May 3, 2022, World Health Organization stay Geneva convene press conference , announced that as of May 1, there were 20 countries and regions 228 children reported Acute hepatitis of unknown cause , another 50 Suspected case Further investigation is needed. [2]
On May 6, 2022, the U.S. Centers for Disease Control and Prevention said that 109 children with unknown causes have been reported in the United States Acute hepatitis Cases, 5 of them died. The agency is investigating the cause of these cases. So far, there is no evidence that these children's hepatitis cases are associated with new coronavirus infection or vaccination New coronal vaccine of [3]
On May 10, 2022, the South Korean Central Anti epidemic Countermeasures Headquarters said that on May 1, South Korea reported a suspected case of acute hepatitis in children with unknown causes. [4]
May 10, 2022 local time, Canada Toronto According to the Children's Hospital, there have been 7 cases of severe acute hepatitis with unknown causes. The hospital said the cases were of "unknown origin". [5]
On May 10, 2022, Sweden public health bureau Said that up to now, there have been 9 cases of acute hepatitis in children with unknown etiology in Sweden, and the bureau urged medical staff to treat these suspected diseases Be alert. [7]
May 12, 2022, Deputy Governor of Jakarta, Indonesia Ahmed Riza Patria According to the introduction, the local government recorded 21 cases of acute hepatitis with unknown causes, 14 of which were children under the age of 16. He said: "In 21 cases, 3 people have died." It is understood that 21 cases of suspected acute hepatitis of unknown cause found in Indonesia have no history of traveling abroad. [6]
2022 to 2023 In April, More than 1000 cases of unexplained childhood hepatitis have been reported in 35 countries, including Britain and the United States. Three independent studies have pointed out that the increase of unexplained childhood hepatitis cases since 2022 is related to adeno-associated virus type II (AAV2), a common childhood virus [9]

Prevention of hepatitis

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Prevention of hepatitis E virus [8]
(1) Pregnant women should be vaccinated half a year in advance Hepatitis E vaccine
(2) Do a good job personal hygiene , Note Dietetic hygiene Wash your hands before and after meals without drinking raw water.
(3) Isolation treatment Hepatitis E patient. Temporary isolation points should be set up to treat early patients.
(4) Close contacts (Eat, live, live together or contact frequently with hepatitis E patients HEV For those who do not take protective measures for pollutants), it shall be implemented for 60 days from the last contact Medical observation