MyofibrilThe constituent proteins of,MyosinandActin。In addition, troponinTropomyosin、αActin、Beta actin,M proteinC protein, etc. It is inferred that there are other unknown trace components.
The protein contained in muscle is about 20% of its wet weight.It exists in the muscle plasmaGlycolysis systemAnd myoglobin (water-soluble), nuclear, mitochondrial, ribosome and other organelle proteins.
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Severe burn sepsis patientsSkeletal muscle proteinDegradation and its biological mechanism.Collect 9 cases of severe burns treated at the same timeSepsisPeople(Burn sepsisBlood, 24h urine and quadriceps femoris samples of 9 plastic surgery patients (control group) were measured by radioimmunoassayTNF-αContent of,High performance liquid chromatographyDetect 24h urine 3-Methyl histidine(3-MH) discharge,Ribonucleic acidImprinting andImmunohistochemical methodDetection of Ubiquitin System in Quadriceps Femorisgene expressionAnd protein expression.The results showed that the concentration of endothelin and TNF - α in the burn sepsis group was significantly higher than that in the control group (P<0.01);The 24-hour urinary 3-MH excretion was significantly higher than that of the control group (P<0.01), and the 3-MH excretion was significantly positively correlated with the changes of peripheral blood cortisol and TNF - α concentrations (r=0.93 or r=0.95,P<0.01);The expression of ubiquitin mRNA2.4 kb band and 1.2 kb band in quadriceps femoris muscle was 52% and 34% higher than that in control group, respectively,C2 subunit mRNACompared with the control group, the expression of β - lactamase increased by 46%, with a significant difference (P<0.01);The expression of ubiquitin protein in quadriceps femoris was significantly higher than that in control group.It indicates that the degradation of skeletal muscle protein in patients with severe burn sepsis is significantly enhancedGlucocorticoidThe increased content of TNF - α and ubiquitin system, which activate the intracellular protein degradation pathway at the gene level, may be one of the reasons for the increased degradation of skeletal muscle protein in patients with severe burn sepsis.[1]
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Myoprotein
insulinEffect of treatment on the high degradation of skeletal muscle protein in scald sepsis: Objective To explore the regulation of insulin on the high degradation of skeletal muscle protein in scald sepsis. Methods The rabbit models of scald and sepsis were established by scalding with boiling water and injecting endotoxin, and insulin was used to control blood sugar.Detect the protein degradation rate andProteasomeThe gene and protein expression changes of.Results Insulin treatment significantly reduced the post injurySkeletal muscle protein decreaseHydrolysis rate and proteasome expression.Conclusion Insulin can inhibit the enhancement of ubiquitin proteasome pathway activity and alleviate the high degradation of skeletal muscle protein in scald and sepsis.