methicillin-resistant staphylococcus aureus

Staphylococcus spp. of Micrococcaceae

In recent years, multiple drug resistance Staphylococcus aureus Caused by Nosocomial infection Not only Clinician The thorny problems that must be faced frequently have posed a great threat to the health of all mankind. all the time, vancomycin It's all clinical treatment Gram positive bacteria The drug of choice for infection was once called the "last bottom line" of clinical anti infection. However, vancomycin resistant Staphylococcus aureus has been isolated in many countries, which puts forward an urgent demand for the development of new anti infective drugs.

Chinese scientific name: methicillin-resistant staphylococcus aureus
Latin name: Staphalococcus aureus

section: Micrococcaceae
genus: Staphylococcus

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brief introduction

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Staphylococcus aureus (Staphalococcus aureus) is a gram-positive coccus, Micrococcaceae ， staphylococcus Genus. It can cause suppurative inflammation, such as furuncle, carbuncle, etc. When bacteria invade the blood, it can cause pathogenicity septicemia 。 Some staphylococci produce thermotolerant enterotoxin , causing food poisoning 。

characteristic

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At first, the sensitivity of Staphylococcus aureus to penicillin was more than 90%, so most of them antibiotic It has played a very good role in treating the symptoms caused by Staphylococcus aureus clinically. However, with the massive use of antibiotics, penicillin resistant Staphylococcus aureus also appeared, followed by other antibiotic resistant Staphylococcus aureus, such as tetracycline 、 erythromycin Etc. So for a long time, the treatment of drug-resistant Staphylococcus aureus infection did not achieve the desired effect. Microbial resistance mutations are DNA molecule The result of the structural change at a specific location of a drug has nothing to do with the existence of a drug. The existence of a drug is only a means to isolate a drug resistant strain.^[1]

Drug resistance

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In natural state, Staphylococcus aureus is only resistant to penicillin and tetracycline, while it is resistant to erythromycin chloramphenicol 、 streptomycin There is no resistance, and the resistance of Staphylococcus aureus to penicillin is greater than that of tetracycline. Staphylococcus aureus Sodium nitrite After mutagenesis, penicillin erythromycin The resistance to chloramphenicol, streptomycin and tetracycline increased, but the resistance to tetracycline decreased. After mutagenesis, the resistance of Staphylococcus aureus to most antibiotics has been improved, and sodium nitrite mutagenesis is beneficial to the drug resistance of Staphylococcus aureus.

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