Bradykinin (BK) is a 9-peptide substance with cardioprotective effect, which can reduce acuteIschemia reperfusionThe infarct area of the myocardium, and medicine has confirmed that BK also has a delayed protective effect on ischemia reperfusion myocardium.
1. Linear chain 9 peptide.byKininOne of.Its structure sequence is Arg, Pro, ProGly、Phe、Ser、Pro、Phe、Arg。It can relax blood vessels and lower blood pressure.
It is found that BK can improve cardiac muscleischemia EarlyATPandPhosphocreatineContent of, so thatGlycogenReduction of decomposition,lactic acidThe production is reduced, thus improving the anti ischemic ability of myocardium, and this result alsoPartial explanationThe BK we found beforesyncopeMyocardial protectionstayMyocardial ischemiaAt 40 minenergy metabolismThere is no significant difference in the indexes, which may be due to the depletion of myocardial energy reserve andMyocardial metabolismAfter reperfusionATP、PhosphocreatineandGlycogenAgain higher thancontrol groupThe content of lactic acid was significantly lower than that of the control group, which may be due to the delayed reduction of BK pretreatmentIschemia reperfusionmiocardial infarctionIt is not difficult to understand that the number of viable myocardium in myocardial ischemic area in BK group is significantly more than that in control group, the content of ATP, phosphocreatine and glycogen must be higher than that in control group, while the content of lactic acid is lower than that in control group. But why can BK improve theenergy metabolismFurther discussion is needed.
