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histamine

One of self active substances

synonym Histamine (an active amine compound) generally referring to histamine

This entry is made by Compilation and application of scientific encyclopedia entries of "Science Popularization China" authentication.

Histamine, an organic nitrogen compound, is produced by histidine under the action of decarboxylase. Many tissues, especially mast cells of skin, lung and intestinal mucosa, contain a large amount of histamine. Histamine can be released when tissue is damaged or inflammation and allergic reaction occur. Histamine has a strong vasodilator effect, and can increase the permeability of capillary and venule walls. Plasma leaks into tissues, leading to local tissue edema.^[1]

Chinese name

histamine^[2]

Foreign name

Histamine^[2]

alias

1H-imidazol-4-ethylamine^[2] 、 Histamine^[2]

nature

One of self active substances

synthesis

In vivo by histidine Decarboxylated

Poisoning phenomenon

Flush, dizziness, headache, nausea, arrhythmia

test method

ELISA method

chemical formula

C five H nine N three^[2]

atlas

Science popularization in China

Committed to authoritative science communication

The certification expert of this term is

Zhang Zheng | Pharmacist in charge

Pharmacy Department of Beijing Chaoyang Hospital to examine

Qiu Kui | Deputy Chief Pharmacist

Pharmacy Department of Beijing Chaoyang Hospital to examine

catalog

seven Drug contraindication

essential information

Chinese name: histamine^[2]
Foreign name: Histamine^[2]
Alias: 1H-imidazol-4-ethylamine^[2] 、 Histamine^[2]
Nature: One of self active substances
Synthesis: In vivo by histidine Decarboxylated
Poisoning phenomenon: Flush, dizziness, headache, nausea, arrhythmia
test method: ELISA method
chemical formula: C five H nine N three^[2]
molecular weight: one hundred and eleven point one four five^[2]

Appearance: White crystalline powder
CAS login number: 51-45-6^[2]
EINECS login number: 200-100-6^[2]
Density: 0.990 g/cm³
Melting point: 83 to 84 ℃^[2]
Flash point: 180.3 ℃
Security description: S22；S26；S36/37^[2]
Hazard symbol: Xn^[2]
Hazard description: R22；R36/37/38；R42/43^[2]
UN dangerous goods number: two thousand eight hundred and eleven^[2]

Physical and chemical properties

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Density: 0.990g/cm three

Melting point: 83-84 ℃

Flash point: 180.3 ℃

Refractive index: 1.567

Molecular structure data

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Molar refractive index: 31.86^[2]

Molar volume (cm three /mol）：97.4^[2]

Isotonic specific volume (90.2K): 266.6^[2]

Surface tension (dyne/cm): 56.0^[2]

Polarization (10 -24 cm three ）：12.63^[2]

Calculate chemical data

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1. Reference value for drainage parameter calculation (XlogP): None

2. Number of hydrogen bond donors: 2^[2]

3. Number of hydrogen bond receptors: 2^[2]

4. Number of rotatable chemical bonds: 2^[2]

5. Number of tautomers: 2^[2]

6. Topological molecular polar surface area: 54.7^[2]

7. Number of heavy atoms: 8^[2]

8. Surface charge: 0^[2]

9. Complexity: 64.7^[2]

10. Number of isotope atoms: 0^[2]

11. Determine the number of atomic structure centers: 0^[2]

12. Number of uncertain atomic structure centers: 0^[2]

13. Determine the number of chemical bond structural centers: 0^[2]

14. Number of indeterminate chemical bond structure centers: 0^[2]

15. Number of covalent bond units: 1^[2]

indication

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1. It is mainly used for the examination of gastric secretion function to identify whether patients with gastric cancer and pernicious anemia have true gastric acid deficiency. At present, pentapeptide acid stimulating hormone is commonly used instead of this product in clinical practice.

2. Auxiliary diagnosis of leprosy.

3. It is also used for desensitization in clinic, that is, repeated incremental injection of small doses of histamine can improve the tolerance of patients to histamine. This method has certain therapeutic effect in treating patients with unknown causes of allergy after specific examination.