The lowest oral dose was given to rats 6~15 days after pregnancyPoisoning dose(TDLo) 15mg/kg, causing blood and lymphPhylogenyDeformities (including spleen and bone marrow).
The mice were given the lowest toxic dose (TDLo) 60mg/kg intraperitoneally on the 11th day after pregnancy, resulting in craniofacial (including nose and tongue) and musculoskeletal system malformations.
IARCCarcinogenicity comment: G3, insufficient evidence of carcinogenicity to humans and animals.
5. Others
Mice were intraperitoneally injected with the lowest toxic dose (TDLo): 60mg/kg (on the 11th day of pregnancy), resulting in stillbirth, craniofacial, skeletal muscledysplasia。
Rats were intraperitoneally injected with the lowest toxic dose (TDLo): 15mg/kg (administered on the 13th day of pregnancy), causing embryosDevelopmental retardation。[1]
methylParathionIt is highly toxic, efficient and broad-spectrumOrganophosphorus insecticide, with touch killing andGastrotoxic effect, can inhibit pestsnervous systemThe activity of cholinesterase,Insecticidal spectrumIt is widely processed into emulsifiable concentrate or powder for use. Its control object is similar to parathion, and it can control a variety of pests on rice, cotton, fruit trees, tea, vegetables and other crops.
Emergency disposal
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Skin contact: immediately take off the contaminated clothes, and thoroughly wash the contaminated skin, hair, nails, etc. with soapy water and flowing water.Get medical attention.
Eye contact: lift the eyelid, use flowing water ornormal salinerinse.Get medical attention.
Inhalation: quickly leave the site to a place with fresh air.keeprespiratory tractunobstructed.asdyspnea, give oxygen.asApnea, perform artificial respiration immediately.Get medical attention.
Ingestion: drink enough warm water to induce vomiting.Use clean water or 2%~5%sodium bicarbonateGastric lavage with solution.Get medical attention.
Other protection: smoking, eating and drinking are prohibited at the work site.After work, take a shower and change clothes.coverallNot allowed to take to nonWorkplace。Store the clothes contaminated by poisons separately and use them after washing.Keep good hygiene habits.
Leakage emergency treatment
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Evacuate the personnel in the leakage contaminated area to a safe area quickly, isolate them, and strictly restrict access.Cut off the ignition source.proposalEmergency ManagementPersonnel shall wear self-contained positive pressure respiratorsAntivirus clothing。Nodirect contact Leakage.In case of liquid, cut off the leakage source as far as possible to prevent the inflowsewer、Flood discharge ditchAnd so on.Small amount of leakage: absorb or absorb with sand or other incombustible materials.Large amount of leakage: build a dike or dig a pit to receive.Remove under the guidance of experts.If it is a solid, avoid raising dust and use cleanShovelCollect in a dry, clean, covered container.In case of large leakage, collect and recycle or transport towaste disposalSite disposal.
Operation, storage and transportation
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Operation precautions: closed operation,Local exhaust。Operators must be specially trained and strictly abide byOperating Procedures。It is recommended that operators wear self-priming filter gas masks (full face masks), one-piece adhesive tape gas jackets and rubber gloves.Keep away from kindling and heat source,WorkplaceSmoking is strictly prohibited.。Use explosion-proofventilation system And equipment.Prevent smoke or dust from leaking into the air of the workplace.Avoid contact with oxidants.Load and unload gently during transportation to prevent damage to packaging and containers.Equipped with corresponding varieties and quantitiesFire EquipmentandLeakage emergency treatmentEquipment.Empty containers may leave harmful substances.
Precautions for storage: store in a cool and ventilated warehouse.Keep away from kindling and heat sources.The warehouse temperature should not exceed 30 ℃.Packing and sealing.It shall be stored separately from oxidants and edible chemicals, and mixed storage is strictly prohibited.Equip with corresponding types and quantities of fire-fighting equipment.The storage area shall be equipped with leakage emergency treatment equipment and appropriate materials.The "five pairs" of extremely toxic substances should be strictly implementedmanagement system。
Transportation precautions: railway transportation shall be strictly in accordance with the Ministry of Railways《dangerous goodsThe dangerous goods shall be loaded according to the dangerous goods loading table in the Transportation Rules.Check before transportationPackaging containerWhether it is complete and sealed,Transportation processThe container shall not leak, collapse, fall or be damaged.It is forbidden to mix with acids, oxidants, food andfood additivesMixed transportation.During transportation, the transportation vehicles shall be equipped with corresponding types and quantities of fire-fighting equipment and leakage emergency treatment equipment.During transportation, it shall be protected from sun exposure, rain and high temperature.road transportWhen driving, please follow the specified routeresidence communityandDensely populated areastop.
Emergency medical treatment
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Diagnostic points
1. WithCholinergic nerveA series of manifestations of overexcitement.
2. Intermediary period occurs in the course of a few patientsMyastheniaSyndrome.
2. The skin polluter should clean thoroughly with soapy water as soon as possible, especially the hair and nails.
3、atropineClass A and oxime cholinesterase reactivators have good effects, and they are used in combination for patients with moderate and severe poisoning.
2. YesMelon It is easy to cause drug damage and should not be used.
3. Methylparathion can cause poisoning through the esophagus, respiratory tract and skin, and can be treated by injection or atropine orDephosphodine, should also controlpulmonary edema、Cerebral edemaAnd respiratory depression.
security information
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Safety terminology
S26：In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
After eye contact, immediately flush with plenty of water and seek medical advice.
S28：After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer).
After skin contact, immediately use a large amount of(designated by the manufacturer).
S36/37：Wear suitable protective clothing and gloves.
Wear appropriate protective clothing and gloves.
S45：In case of accident or if you feel unwell, seek medical advice immediately (show the lable where possible).
In case of an accident or feeling unwell, seek medical advice immediately (show the label if possible).
S60：This material and/or its container must be disposed of as hazardous waste.
The substance and its container must be used asHazardous wastemanagement.
S61：Avoid release to the environment. Refer to special instructions/Safety data sheets.
Avoid releasing into the environment, refer to special instructions/safety receipt instructions.
S62：If swallowed, do not induce vomiting: seek medical advice immediately and show this container or label.
Do not induce vomiting after swallowing: seek medical advice immediately and show the container or label.
Risk terminology
R5：Heating may cause an explosion.
Heating may cause explosion.
R24：Toxic in contact with skin.
Toxic in contact with skin.
R26/28：Very toxic by inhalation and if swallowed.
Very toxic by inhalation and if swallowed.
R48/22：Harmful : danger of serious damage to health byprolongedexposure if swallowed.
Harmful: danger of serious damage to health if swallowed and exposed for a long time.
R50/53：Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment.
