Glycolipids with glycerol as the common component, and sugar molecules are directly bound to diglycerides
GlyceroglycolipidglycerolIs a common component, while sugar molecules are directly bound toDiglycerideThe general name of glycolipids (excluding phosphorus).
Together with nerve glycolipids, they form two major categories of glycolipids.Nerve glycolipids are the main glycolipids in the animal kingdom, while glycerol glycolipids are widely found in higher plants, followed by green algae and bacteriaimportantIt is inositol phosphate oligomannoside that exists in the single or double galactoside diglycerol on the chloroplast membrane of tuberculous bacteria.There is also a small amount of galactosideDiglycerolIt exists in the brain.[1]
Related research
Announce
edit
Inhibitory effect of glyceryl sulfate glycolipid on tumor cell proliferation in vitro
[Title] Study on the inhibitory activity of glyceryl sulfate glycolipid on tumor cell proliferation in vitro
[Author] Wang Hui, Li Yaolan, Shen Weizai, Guo Guoqing, Cen Yingzhou, Jiang Zhenyou
[Institution] Department of Anatomy, Medical College of Jinan University, Guangzhou 510632, GuangdongSchool of Pharmacy, Jinan UniversityTraditional Chinese medicine andNatural Products Research InstituteDepartment of Chemistry, Jinan University Department of Microbiology and Immunology, Medical College, Jinan University, Guangzhou 510632, Guangdong
[Name] Journal of Jinan University: Natural Science and Medicine Edition, 2007 (2): 136-141
[Abstract] Objective: To detect the anti-tumor activity in vitro of algal glyceryl sulfate glycolipids (SQDG), and to provide theoretical basis for finding effective new anti-cancer drugs.Methods: MTr method was used to detect the cytotoxicity of SQDG to normal cells.stayinverted microscopeTo observe the morphological changes of seven kinds of human tumor cells after being treated with SQDG for 72 hours, and to quantitatively measure their growth by MTr methodInhibitionAt the same time, the changes of cell cycle were detected by flow cytometry.Results: The toxicity of SQDG to normal cells Vero and MC was very small, and its CC50 values were both greater than 50 μ g/mL.It's rightHuman breast cancer cellsThe growth inhibition effect of MCF-7 was the most obvious, IC50 value was 69.1 μ g/mL, and the growth of MCF-7 cells was completely inhibited when the mass concentration was 125 μ g/mL.SQDG also has a certain inhibitory effect on H460, A549, HEp2 and HeLa cells, but has little effect on HepG2 and A375 cells.Flow cytometry detection found that SQDG can disrupt the cell cycle of MCF-7, promote cell apoptosis or necrosis, and thus produce effective growth inhibition effect.However, SQDG is not suitable for H460 andHepG2 cellsThe change of cycle was not statistically significant.Conclusion: Glycerol Sulfate Glycolipid SQDG has a significant effect on normal cellsNontoxic, can selectively and effectively inhibit the growth of breast cancer cells in vitrodevelopment potentialAntineoplastic drugs.
