Citrulline

In white crystalline form

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Citrulline is a α - amino acid , chemical formula is C six H thirteen N three O 3。

suffer from Rheumatoid arthritis % of patients (about 80%) will develop a set of immune reaction Anti citrulline protein 。 Although the cause of this reaction mechanism is unknown, detecting antibodies can help to diagnose this kind of disease.

Chinese name: Citrulline
Foreign name: Citrulline
Alias: (S) 2-Amino-5-ureavalproate carbamoylornithine
chemical formula: C six H thirteen N three O three
molecular weight: one hundred and seventy-five point one nine

CAS login number: 372-75-8
EINECS login number: 206-759-6
Melting point: 222 ℃
Water solubility: Soluble in water
Density: 1.289 g/cm³
Appearance: White crystalline

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brief introduction

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Molecular Structure Diagram

Citrulline Is a kind of α - amino acid , because first from watermelon It is called citrulline.

IUPAC Chinese name	2-Amino-5 - (aminoformylamino) n-valeric acid
CAS No	372-75-8
chemical formula	C6H13N3O3
Molar mass	175.2 g mol
melting point	236 ℃

synthesis

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Synthetic pathway of citrulline in vivo (2 sheets)

Citrulline is derived from Ornithine And amino formyl phosphate are generated in the urea cycle, or Nitric oxide synthase (NOS) Catalysis Arginine Produce by-product of NO.

metabolize

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First, arginine will be oxidized to N-hydroxy-arginine, then oxidized to citrulline and released nitric oxide 。

function

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When citrulline is still amino acid Because it is not DNA The code, therefore, will not be Protein Biosynthesis It is embedded in proteins, but some proteins still contain citrulline. These citrulline are produced by Peptide Arginine ammoniase (PAD) is produced during the ammoniation of melon Arginine Conversion to citrulline. Generally, proteins containing citrulline include Human brain myelin basic protein （ MBP ）, poly Keratin Microfilament Protein and some Histone 。 Such as cellulose and Vimentin From cell death And ammoniated melon in tissue inflammation.

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