Salicin is an organic substance with chemical formula CthirteenHeighteenOseven, colorless crystal or white powder, soluble in water, soluble in boiling water, insoluble in ethanol (1:90), insoluble in ether or chloroform, but soluble in alkali solution, pyridine or glacial acetic acid, with hygroscopic properties.It is widely found in the bark and leaves of many willow and poplar plants. For example, salicin can reach 30% in the bark of purple willow.
Water solubility 36 G/L (15 º C), 250 G/L (60 º C)
Safety terminology
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S24/25Avoid contact with skin and eyes.
Avoid contact with skin and eyes.
S37Wear suitable gloves.
Wear appropriate gloves.
Risk terminology
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R43 May cause sensitization by skin contact.
May cause sensitization in contact with skin.
Material introduction
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Salicin is white crystal;Bitter taste;Melting point 199-202 ℃, specific rotation【α】- 45.6 ° (0.6g/100cm3 absolute ethanol);Soluble in water, soluble in boiling water, insoluble in ethanol (1:90), insoluble in ether or chloroform, but soluble in alkali solution, pyridine or glacial acetic acid.Its aqueous solution is neutral, and there is no free phenol in the moleculehydroxyl, belonging to phenolic glycosides.After diluted acid orBitter almond enzymehydrolysis, can produce glucose andSalicylic alcohol。The molecular formula of salicylic alcohol is C7H8O2;It is rhombic colorless needle crystal;Melting point 86~87 ℃;Heat to 100 ℃ for sublimation;Soluble in water, benzene,SolubleIn ethanol, ether, chloroform;It will be red in case of sulfuric acid.
effect
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Salicin has antipyretic and analgesic effects. It was used to treat rheumatism in the past and has been replaced by other drugs.Because it can produceSalicylic alcohol, easy to be oxidized to produce salicylic acid, so it was once syntheticSalicylatesThe main source of drugs, salicylic acid drugs have been produced by synthetic method in the pharmaceutical industry