Methyl chloride

Organic compound

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Methyl chloride, also known as methyl chloride, is a Organic compound , chemical formula is CH three Cl， It is a colorless gas at normal temperature and pressure, slightly soluble in water, soluble in ethanol, chloroform, benzene, carbon tetrachloride, glacial acetic acid, etc. It is mainly used as the raw material of organic silicon, and also as solvent 、 Cryogen 、 spice Etc.

On October 27, 2017, World Health Organization International Agency for Cancer Research The published list of carcinogens is preliminarily collated for reference. Methyl chloride Category 3 carcinogens List.^[2]

Chinese name: Methyl chloride
Foreign name: Methyl chloride
Alias: Methyl chloride 、 R40 、 Monochloromethane
chemical formula: CH three Cl
molecular weight: fifty point four eight seven
CAS login number: 74-87-3
EINECS login number: 200-817-4

Melting point: -97 ℃
Boiling point: -24.2 ℃
Water solubility: Slightly soluble
Appearance: Colourless gas
Flash point: -46 ℃
Security description: S9；S16；S33
Hazard description: R12

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essential information

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Chemical formula: CH three Cl

Molecular weight: 50.487

CAS No. 74-87-3

EINECS No.: 200-817-4

Physical and chemical properties

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Melting point: - 97 ℃

Boiling point: - 24.2 ℃

Flash point: - 46 ℃

Refractive index: 1.0007

Saturated vapor pressure: 506.62kPa (22 º C)

Critical temperature: 143.8 º C

Critical pressure: 6.68MPa

Ignition temperature: 632 º C

Upper explosive limit（ V / V ）：17.4%

Lower explosive limit（ V / V ）：8.1%

Appearance: colorless gas

Solubility: slightly soluble in water, soluble in ethanol, chloroform, benzene, carbon tetrachloride, glacial acetic acid, etc^[1]

Molecular structure data

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Molar refractive index: 11.53

Molar volume (cm three /mol）：56.4

Isotonic specific volume (90.2K): 110.3

Surface tension (dyne/cm): 14.6

Polarization (10 -24 cm three ）：4.57^[1]

Calculate chemical data

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Reference value for drainage parameter calculation (XlogP): 0.8

Number of hydrogen bond donors: 0

Number of hydrogen bond receptors: 0

Number of rotatable chemical bonds: 0

Number of tautomers: 0

Topological molecule polar surface area (TPSA): 0

Number of heavy atoms: 2

Surface charge: 0

Complexity: 2

Number of isotope atoms: 0

Determine the number of atomic structure centers: 0

Number of uncertain atomic structure centers: 0

Determine the number of chemical bond structure centers: 0

Number of uncertain chemical bond structure centers: 0

Number of covalent bond units: 1^[1]

toxicology data

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1、 acute toxicity

LC fifty ：5300mg/m three (Inhalation of rats, 4h)

2、 Mutagenicity

Microbial mutagenesis: Salmonella typhimurium 2500ppm。

Sister chromatid exchange: 3% of human lymphocytes.

Somatic cell mutation in mammals: 5% in human lymphocytes.

Out of program DNA synthesis: rat liver 1%.

Dominant lethal test: rats inhaled 3000 ppm for 6 hours a day for 5 consecutive days.

3、 Teratogenicity

Inhalation of the lowest toxic dose (TCLo) of 1500 ppm/6h at 7-19 days after pregnancy in rats caused malformation of musculoskeletal system development.

The lowest toxic dose (TCLo) of 500 ppm/6h was inhaled 6~17 days after pregnancy in mice, resulting in cardiovascular system malformation.

4. Carcinogenicity

IARC carcinogenicity review: G3, insufficient evidence of carcinogenicity to humans and animals.

5. Others

Reproductive toxicity: affects testis and spermatogonia. Embryonic development toxicant.^[1]

Ecological toxicity

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1. Ecotoxicity

LC50: 270ppm (96h) (monthly silverfish, static); 550ppm (96h) (Bluegill sunfish, static)

IC50: 500~1450mg/L (72h) (algae)

2. Non biodegradable

In the air, when the concentration of hydroxyl radical is 5.00 × 10 five Pcs/cm three The half-life of degradation is 310 d (theoretical).^[1]

purpose

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It is mainly used as the raw material of organosilicon, as well as solvent, refrigerant, spice, etc.

Storage method

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It shall be stored in a cool and ventilated special warehouse for toxic gases. Keep away from kindling and heat sources. The warehouse temperature should not exceed 30 ℃. It shall be stored separately from oxidant and shall not be mixed. Explosion proof lighting and ventilation facilities shall be adopted. It is prohibited to use mechanical equipment and tools that are easy to generate sparks. The storage area shall be equipped with leakage emergency treatment equipment.