Structure-activity relationship
Structure activity relationship, pharmaceutical terminology.
- Chinese name
- Structure-activity relationship
- Foreign name
- structure activity relationship
- Abbreviations
- SAR
Explanation of terms
structure activity relationship；SAR
Explanation 1: structure-activity relationship refers to drugs or other Physiologically active substance Of Chemical structure The relationship between it and its physiological activity is Pharmaceutical chemistry One of the main research contents of. The narrow sense of structure-activity relationship is about drugs, while the broad sense of structure-activity relationship is about all chemicals with physiological activity material , including drugs, pesticides, chemical poisons, etc. The earliest structure-activity relationship studies qualitatively speculated physiology in an intuitive way Active substances The relationship between structure and activity, and then speculate Target enzyme Active site And design new active substance structure Development of information technology , with computer as Auxiliary tools Of QSAR It has become the main direction of structure-activity relationship research, and quantitative structure-activity relationship has also become Rational drug design One of the important methods of. Explanation 2: Drug Chemical structure Relationship with efficacy. According to the degree of influence of chemical structure of drugs on biological activity, drugs are divided into non Specificity Structural drugs and specific structural drugs. The relationship between the biological activity and structure of the former is mainly determined by these drugs Physical and chemical properties Determined. For most drugs, their chemical structure and activity are interrelated. Drugs generally bind to receptors on body cells and then exert their effects Chemical reactivity 、 functional group The distribution, the shape and size of molecules and their three-dimensional arrangement must be adapted to the receptor. 
