Configuration isomerism: it refers to the isomerism phenomenon caused by the different spatial arrangement of atoms in macromolecules [1] 。
include Cis trans isomerism 、 Enantiomerism (also called optical isomerism), etc. To change an isomer into its configurational isomer, two bonds in the molecule must be broken, and then the spatial positions of the two groups must be exchanged. Unlike conformational isomerism, conformational isomerism can change one conformational isomer into another as long as the bond is twisted. 
